Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lower urinary tract symptoms (LUTS) including urinary frequency and nocturia are common in aging men. Recent studies have revealed a strong association of prostatic inflammation with LUTS. We developed an animal model of bacterial induced, isolated prostatic inflammation and examined the effect of prostatic inflammation on voiding behavior in adult C57BL/6J mice. Prostatic inflammation was induced by transurethral inoculation of uropathogenic E. coli-1677. Bacterial cystitis was prevented by continuous administration of nitrofurantoin. Hematoxylin and eosin (H&E) staining and bacterial culture were preformed to validate our animal model. Voiding behavior was examined by metabolic cage testing on post-instillation day 1 (PID 1), PID 4, PID 7 and PID 14 and both voiding frequency and volume per void were determined. Mice with prostatic inflammation showed significantly increased voiding frequency at PID 1, 7 and 14, and decreased volume per void at all time points, as compared to mice instilled with saline and receiving nitrofurantoin (NTF). Linked analysis of voiding frequency and voided volumes revealed an overwhelming preponderance of high frequency, low volume voiding in mice with prostatic inflammation. These observations suggest that prostatic inflammation may be causal for symptoms of urinary frequency and nocturia.
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PMID:Prostatic inflammation induces urinary frequency in adult mice. 2564 72

A novel eddy-current Magnetic Clutch (MC) unit with its torque-adjustable mechanism is proposed by this research. As to mechanical structure, the MC unit is mainly constituted by a squirrel-cage inner rotor and a magnet-embedded outer rotor. The transmitted output torque can be adjusted by either the Overlapped Length (OL) or the relative angular velocity between outer rotor and inner rotor. Firstly, the mathematical model of the MC system is developed. Secondly, the features and characterization of the MC unit are explored by intensive experiments under various overlapped length and relative rotational speed between inner rotor and outer rotor. The major novelties of the MC system unit include: (i). being very handy to operate even for non-professional users, (ii). the output torque of the proposed MC can be adjusted automatically, and (iii). the proposed MC can be easily incorporated to any torque control system. To examine the validity of the MC unit, two control strategies, i.e., PID action and pole-placement method are presented and compared for the performance of the closed-loop feedback systems. In addition, the locations of system roots are found to ensure the stability of the torque control loops. At last, several experiments are undertaken, including constant torque control and variable torque control. Particularly, an experiment of screw-driven into a wooden board is conducted to illustrate the drilling quality much upgraded by the proposed torque control device. Besides, a couple of torque-tracking experiments realistically manifest the quick response and high precision of the MC unit. In summary, either for stability or performance, the proposed MC feedback system is eligible to execute superior torque tracking or torque regulation.
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PMID:Linear magnetic clutch to automatically control torque output. 2962 52