Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:Q86TM3 (
cage
)
29,987
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Hepatocellular carcinoma (HCC) is the third leading cause of
cancer-associated
death. Due to rapid progression and metastasis, the long-term survival remains poor for most patients. Thus, it is important to discover and develop novel preventive strategies and therapeutic approaches for HCC. Recent data show that
chondrolectin
(
CHODL
) is commonly overexpressed in the majority of lung cancers, indicating a possible correlation between
CHODL
and metastasis of lung cancer cells. Our investigation shows that the expression of
CHODL
is significantly decreased in HCC clinical samples and in HCC cell lines. Overexpression of
CHODL
in SMMC7721 cells with a lentiviral vector increased SMMC7721 cell migration and invasion. Our findings establish for the first time an association between human
CHODL
and HCC metastasis.
...
PMID:Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells. 2835 50
