Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Cancer was diagnosed in 15 patients among 300 consecutive patients with intermittent claudication. The cancer-associated claudication is characterized by a more accelerated course of claudication, more often requires vascular surgery, and moreover, the lasting relief of claudication depends upon the efficiency of cancer therapy. It is the authors' impression that cancer-associated claudication is predetermined by atherosclerosis and aggravated by cancer through the chronic hypercoagulability state secondary to neoplasm. The clinical picture is characterized by rapid progression, with the frequent necessity of vascular surgery for limb salvage and a higher incidence of graft occlusion. Awareness of this possibility of hidden malignancy may be related to the clinical picture of hemodynamic deterioration of the underlying arterial insufficiency. A high index of suspicion leads to earlier diagnosis of neoplasm. Effective oncologic therapy will often bring the symptomatic relief of ischemic symptoms in the lower extremities. This report indicates that associated neoplasm has a more vicious course of the underlying arterial insufficiency and intermittent claudication.
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PMID:Intermittent claudication associated with cancer--case studies. 366 9

The potential for physical training to enhance collateral-dependent blood flow (BF) to the hindlimbs of aged male rats (Fischer 344) was evaluated following bilateral femoral artery ligation at 20.5 mo of age. Rats were either limited to cage activity (sedentary, n = 11) or trained by a mild-intensity treadmill program (trained, n = 14), which involved walking twice a day at 15 m/min (15% grade) to fatigue, 5 days/wk for 8-11 wk. Exercise tolerance of the trained rats increased from approximately 5 to approximately 25 min/bout by week 7, whereas exercise tolerance of the sedentary group changed little (to approximately 8 min/bout) during the training period. At approximately 23 mo age, animals were surgically prepared for hindquarter perfusion (aortic pressure = 100 +/- 1.3 mmHg) and force measurement of the left gastrocnemius-plantaris-soleus (GPS) muscle group during isometric contractions at 4, 8, 15, 30, and 45 tetani/min via sciatic nerve stimulation (approximately 6 V, 0.1-ms square waves at 100 Hz for 100 ms). Although initial force development was similar between groups (12.9 N/g), trained rats maintained tension better at 8, 15, 30, and 45 tetani/min (P < 0.01). BF to the entire hindlimb of the trained group, determined with 85Sr 15-microns microspheres, was 43% greater (P < 0.05) than in the sedentary group. Thus collateral-dependent BF was improved by physical training. The greatest increase in BF was to the distal limb muscles (approximately 78%), the tissues most at risk during intermittent claudication.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Training increases collateral-dependent muscle blood flow in aged rats. 790 Aug 71

Fifteen patients with Meyerding I spondylolisthesis causing disabling lumbago underwent threaded fusion cage implantation at the unstable segments. Low back pain and intermittent claudication subsided in all patients postoperatively. The preoperative Japan Orthopaedic Association score was 11.5 on average, and improved to 23.5 after surgery. Five patients achieved significant resolution of preoperative symptoms, six improved reasonably, and four required less medication. There was no failure of fixation. No patient required supplemental fixation such as pedicle screws to achieve stable fusion. One patient had an inflammatory course but re-surgery was not necessary. The threaded fusion cage is an effective and promising device for the relief of low back pain when used to promote fusion of the lumbar spine in patients with low-grade spondylolisthesis.
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PMID:Threaded fusion cage for lumbar spondylolisthesis. 959 58