Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 3 1/2-year-old girl was incarcerated in a bamboo cage after it was feared she had contracted rabies. Six years later, when she was released, she had lost almost all motor control, displayed a number of stereotypies, was incontinent of both faeces and urine, and was diagnosed as having grand mal epilepsy. After four years of treatment (aged 13) she had shown considerable improvement and her mental age was seven years.
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PMID:Severe deprivation in childhood: a case report from Thailand. 139 16

In more than 98% of randomly bred gerbils epileptic seizures could be evoked by blowing at the animals with compressed air (5 bars for 10 s). In contrast, only few animals showed seizures in response to environmental stimuli (e.g., new cage) and handling. Thus, administration of drugs was possible without precipitating seizures. The severity of the seizures was rated on a seven-point scale. Seizure severity increased with age and reached its maximum at about 7 months. Comparison of pharmacokinetics of common antiepileptic drugs showed that these drugs, except phenobarbital, were rapidly eliminated by the gerbil which, in this respect, resembled the mouse. For determination of anticonvulsant ED50S of antiepileptic drugs in gerbils there was differentiated between "minor" seizures (grade 1-2; myoclonic seizures) and "major" seizures (grade 3-5; generalized clonic-tonic seizures). Phenobarbital, phenytoin and carbamazepine were more potent against major seizures than against minor seizures, whereas the reverse situation was obtained with diazepam, valproic acid and ethosuximide. The relative activity of the different antiepileptic drugs against minor and major seizures in gerbils corresponded to the respective activity in traditional mouse models of petit mal and grand mal epilepsy. In further experiments, a series of GABAmimetic drugs was tested, namely, compounds that selectively increase gamma-aminobutyric acid (GABA)-mediated neuronal inhibition in the brain.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Evaluation of anticonvulsant drugs in gerbils with reflex epilepsy. 654 23