Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q86TM3 (cage)
 29,987 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The IIM are a heterogeneous group of systemic rheumatic diseases which share the common features of chronic muscle weakness and mononuclear cell infiltrates in muscle. A number of classification schemes have been proposed for them, but none takes into consideration the marked immunologic, clinical, and genetic heterogeneity of the various clinical groups. We compared the usefulness of myositis-specific autoantibodies (anti-aminoacyl-tRNA synthetases, anti-SRP, anti-Mi-2 and anti-MAS) to the standard clinical categories (polymyositis, dermatomyositis, overlap myositis, cancer-associated myositis, and inclusion body myositis) in predicting clinical signs and symptoms, HLA types, and prognosis in 212 adult IIM patients. Although patients with inclusion body myositis (n = 26) differed in having significantly more asymmetric and distal weakness, falling, and atrophy than other patients, there were few other significant differences among the other clinical groups. In contrast, autoantibody status defined distinct sets of patients and each patient had only 1 myositis-specific autoantibody. Patients with anti-amino-acyl-tRNA synthetase autoantibodies (n = 47), compared to those without these antibodies, had significantly more frequent arthritis, fever, interstitial lung disease, and "mechanic's hands"; HLA-DRw52; higher mean prednisone dose at survey, higher proportion of patients receiving cytotoxic drugs, and higher death rates. Those with anti-signal recognition particle antibodies (n = 7) had increased palpitations; myalgias; DR5, DRw52; severe, refractory disease; and higher death rates. Patients with anti-Mi-2 antibodies (n = 10) had increased "V-sign" and "shawl-sign" rashes, and cuticular overgrowth; DR7 and DRw53; and a good response to therapy. The 2 patients with anti-MAS antibodies were the only ones with alcoholic rhabdomyolysis preceding myositis; both had insulin-dependent diabetes mellitus, and both had HLA-B60, -C3, -DR4, and -DRw53. These findings suggest that myositis-specific autoantibody status is a more useful guide than clinical group in assessing patients with myositis, and that specific associations of immunogenetics, immune responses, and clinical manifestations occur in IIM. Thus the myositis-specific autoantibodies aid in interpreting the diverse symptoms and signs of myositis patients and in predicting their clinical course and prognosis. We propose, therefore, that an adjunct classification of the IIM, based on the myositis-specific autoantibody status, be incorporated into future studies of their epidemiology, etiology, and therapy.
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PMID:A new approach to the classification of idiopathic inflammatory myopathy: myositis-specific autoantibodies define useful homogeneous patient groups. 165 47

Ordered large-pore organosilicas with isocyanurate bridging groups were synthesized via co-condensation of tetraethyl orthosilicate (TEOS) and tris[3-(trimethoxysilyl)propyl]isocyanurate (ICS) in the presence of poly(ethylene oxide)-poly(butylene oxide)-poly(ethylene oxide) (EO(39)BO(47)EO(39)) B50-6600 template under acidic conditions. It was shown that the extraction of the B60-5500 triblock copolymer with acidified ethanol solution was insufficient to remove completely the template; however, calcination of as-synthesized and extracted samples under air atmosphere at 200 degrees C, 250 degrees C and 300 degrees C caused not only the removal of the polymer but also a substantial decomposition of the ICS groups. In contrast, the heat treatment of extracted organosilicas at 360 degrees C in flowing nitrogen was able to fully remove the residual template without degradation of the ICS bridging groups. Characterization of the resulting materials by small angle X-ray scattering (SAXS) and X-ray powder diffraction (XRD) revealed that isocyanurate-containing organosilicas have a body-centered cubic symmetry (Im3m). Argon adsorption-desorption isotherms of these organosilicas revealed cage-like mesopores, high surface areas and large pore volumes. The diameters of spherical cages were found to be very uniform in the range of 12-14 nm. A complete removal of triblock copolymer was confirmed by high-resolution thermogravimetry (TG), Fourier transform infrared spectroscopy (FT-IR) and CHNS elemental analysis (EA). The latter showed that the isocyanurate rings are intact in the framework and their loading is up to 1 mmol g(-1). Moreover, these organosilicas were also synthesized using low acid concentration, double amount of polymer and sodium chloride; in this case the template was completely extracted and there was no need for additional heat treatment.
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PMID:Cage-like mesoporous organosilicas with isocyanurate bridging groups synthesized by soft templating with poly(ethylene oxide)-poly(butylene oxide)-poly(ethylene oxide) block copolymer. 1920 May 52

We investigate the stability of boron fullerene sets B76, B78 and B82. We evaluate the ground state energies, nucleus-independent chemical shift (NICS), the binding energies per atom and the band gap values by means of first-principles methods. We construct our fullerene design by capping of pentagons and hexagons of B60 cages in such a way that the total number of atoms is preserved. In doing so, a new hole density definition is proposed such that each member of a fullerene group has a different hole density which depends on the capping process. Our analysis reveals that each boron fullerene set has its lowest-energy configuration around the same normalized hole density and the most stable cages are found in the fullerene groups which have a relatively large difference between the maximum and the minimum hole densities. The result is a new stability measure relating the cage geometry characterized by the hole density to the relative energy.
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PMID:A new hole density as a stability measure for boron fullerenes. 2414 46