Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q7LGC8 (HSD)
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Human Gene/Protein
CHST13 13.3
GDNF-inducible zinc finger protein 1 13.3
SDR9C4 13.3
C6ST 13.3
HSD 13.3
HSD11B1L protein 13.3
HSD11B1L 12.3
phosphoinositide-3-kinase, catalytic, beta polypeptide 12.3
P-450HP 12.3
HSD8 12.1
CHST1 12.0
HSD-1 11.9
17-beta-HSD 11.9
17 beta-hydroxysteroid dehydrogenase 11.7
PHA I 11.7
FAM89A 11.7
chlordecone reductase 11.5
HSD3 11.5
17beta-hydroxysteroid dehydrogenase type 3 11.5
cytochrome P450, family 2, subfamily D, polypeptide 6 11.3
CHST12 11.3
HSD13 11.3
20 alpha-hydroxysteroid dehydrogenase 11.2
chondroitin 4-sulfotransferase 11.2
HSD5 11.1
HSD1 11.1
3 beta-HSD type II 11.0
hydroxysteroid dehydrogenase-like protein 11.0
GZF1 11.0
RB3 protein 11.0
CKLFSF2 11.0
GST-5 11.0
CHST10 11.0
StAR 10.9
3alpha-HSD 10.8
3-beta-hydroxysteroid dehydrogenase 10.7
PPIL3 10.7
RODH 10.7
TMEM114 10.7
3 beta-HSD 10.7
HSD4 10.6
MT1R 10.6
P450C17 10.5
HSD2 10.5
3 beta-hydroxysteroid dehydrogenase 10.5
RDHL 10.5
CTRB2 10.5
calcium activated nucleotidase 1 10.5
P450scc 10.4
GlcNAc6ST-3 10.4
C4ST-1 10.4
HSD17B6 10.3
Retinol dehydrogenase 10.3
alpha-kinase 1 10.3
P450c17 10.2
SPOCK2 10.2
20alpha-hydroxysteroid dehydrogenase 10.1
GlcNAc6ST-1 10.1
HSD11 10.1
neuregulin 4 10.1
CNTNAP4 10.1
CYP11A 10.1
steroid acute regulatory protein 10.1
HSD17B3 10.0
P450c21 10.0
SULT1C 10.0
17beta-hydroxysteroid dehydrogenase 10.0
GlcNAc6ST-2 9.9
17-beta-hydroxysteroid dehydrogenase 9.8
HSD-3.8 9.8
steroidogenic acute regulatory protein 9.8
CYP11A1 9.8
17beta hydroxysteroid dehydrogenase 9.8
B4GALT7 9.8
PDIA2 9.7
P3H2 9.7
ADP-ribosylation factor 3 9.7
SCHAD 9.7
20-alpha-hydroxysteroid dehydrogenase 9.7
TPST2 9.7
more...
Disease
Benign meningioma 12.7
PHA I 11.7
Sex cord-stromal tumor 11.7
Alcohol-induced pseudo-Cushing's syndrome 11.7
Late onset congenital adrenal hyperplasia 10.7
Chronic inflammatory disease 10.0
Male pseudohermaphroditism 9.9
Desbuquois syndrome 9.8
PHA1 9.3
WNS 9.3
PHA2 9.3
3 beta-HSD deficiency 9.2
Androgen excess 8.6
ADSA 8.5
adrenal hypertension 8.4
testicular dysfunction 8.4
NSD 7.9
spondyloepiphyseal dysplasia 7.7
Leydig cell hyperplasia 7.7
mumps orchitis 7.7
Testes 7.6
Leydig cell hypoplasia 7.6
Gordon's syndrome 7.5
cystic ovary 7.5
Allergic fungal sinusitis 7.4
Hypoxic-ischemic brain injury 7.3
adrenal neoplasm 7.3
IPS 7.3
Liddle's syndrome 7.2
SPG7 6.9
hypokalemic alkalosis 6.9
Male hypogonadism 6.8
11 beta-hydroxylase deficiency 6.7
Pseudopregnancy 6.7
congenital adrenal hyperplasia 6.6
Testis 6.6
Testis 6.6
Ondine's curse 6.5
Ondine's curse 6.5
BCD 6.5
ovarian dysfunction 6.5
Steroids 6.5
Endometrium 6.5
Endometrium 6.4
hyporeninemic hypoaldosteronism 6.4
21-hydroxylase deficiency 6.3
hypercortisolism 6.1
MSD 6.1
Larsen 6.0
adrenal hyperplasia 6.0
ISD 6.0
disruptive behavior disorder 6.0
DHD 5.9
DHD 5.8
FSI 5.8
FHM 5.8
Testicular torsion 5.7
hypoactive sexual desire disorder 5.7
external genitalia 5.7
PMS 5.7
Cushing's syndrome 5.7
chondrodysplasia 5.6
CIE 5.5
endocrine disorder 5.5
moderate obesity 5.5
MSF 5.5
Leydig cell tumor 5.5
FPP 5.4
aldosteronism 5.4
Hallervorden-Spatz disease 5.4
hypochloremia 5.3
anovulation 5.3
Angle Class I 5.3
polycystic ovary syndrome 5.2
Sertoli cell tumor 5.2
HBD 5.2
epididymis 5.2
hypoaldosteronism 5.2
MIN 5.2
MIN 5.2
more...
Symptom
Balding 8.2
Tissue sensitivity 8.2
masculinization 6.6
Cushingoid 6.5
Cushingoid 6.5
voice change 6.0
male subfertility 5.2
Decreased activity 5.2
loss of balance 4.5
CSR 3.8
dry skin 3.3
hypersomnia 3.3
polydipsia 3.2
muscle stiffness 3.0
polyuria 2.7
physical appearance 2.7
sciatica 2.7
rhinorrhea 2.1
acute stress 2.1
pallor 2.0
knee pain 1.8
snoring 1.8
HSA 1.7
flushing 1.6
dysarthria 1.4
acidity 1.4
agitation 1.3
dystonia 1.2
fatigue 1.1
overweight 0.9
ENT 0.9
hunger 0.8
lethargy 0.8
hypothermia 0.8
hepatomegaly 0.8
hypotonia 0.8
back pain 0.7
exhaustion 0.5
distraction 0.1
respiratory distress 0.0
splenomegaly 0.0
low back pain 0.0
anesthesia -0.1
thinning -0.2
discomfort -0.3
starvation -0.3
functional recovery -0.4
tremor -0.9
headache -0.9
pain -1.1
discomfort -1.2
seizures -1.4
dyspnea -1.5
analgesia -1.5
abdominal pain -1.6
vomiting -1.7
weakness -1.9
diarrhea -2.5
Drug
Aicar 12.3
Saccharin sodium 11.3
Trilostane 10.4
Gadofosveset trisodium 10.3
Factrel 9.8
Adosterol 9.7
Carbenoxolone 9.6
Almora 9.1
Ganaxolone 9.0
Phosphagen 8.3
Gestrinone 8.3
Vitamin-E 8.0
CEG 7.8
Benzofuran 7.7
Pregnenolone 7.7
CEG 7.6
Lead acetate 7.6
Alarin 7.4
Cortrosyn 7.3
Calcium silicate 7.1
Cortrosyn 7.1
Ciprofibrate 7.0
DHT 6.9
Dihydrotestosterone 6.9
DHT 6.9
Ethibond 6.6
Ketorolac tromethamine 6.5
Dutasteride 6.4
Digitalis 6.3
Tenoxicam 6.3
FSH-beta 6.3
FSH-beta 6.3
Furan 6.2
Arimidex 6.1
Sulphasalazine 6.0
FSH-beta 6.0
SrCl2 5.9
SrCl2 5.8
Camphor 5.7
Camphor 5.6
Glycyrrhiza 5.6
Bosentan 5.6
Bosentan 5.6
Aztec 5.5
Parlodel 5.5
Estriol 5.5
DEX 5.4
Peridex 5.4
Clodronate 5.3
EMB 5.2
Zmax 5.2
Rosiglitazone 5.2
KCL 5.2
Estrogens 5.1
HCG 5.1
Silica gel 5.1
Ketorolac 5.1
EE2 5.1
R1881 5.0
Clomiphene citrate 5.0
Rimonabant 4.9
RSM 4.8
MAP 4.8
NADH 4.7
ATV 4.7
Modafinil 4.7
Xanthium 4.6
Activin 4.5
Forskolin 4.5
Cibacron Blue 4.4
THF 4.4
Leucovorin 4.3
Luteinizing 4.3
Ketoconazole 4.2
Troglitazone 4.2
Ringer's solution 4.1
CAM 3.8
balanced salt solution 3.7
Florisil 3.7
AGG 3.7
more...
Enzyme
HSD 13.1
chondroitin 6-sulfotransferase 13.0
keratan sulfate sulfotransferase 12.8
3-KSR 12.7
3alpha(17beta)-HSD 12.3
chondroitin 4-sulfotransferase 12.1
11beta-hydroxysteroid dehydrogenase 11.4
17beta-HSD 11.4
3beta-hydroxysteroid dehydrogenase 11.4
17beta-HSD 11.0
12alpha-hydroxysteroid dehydrogenase 11.0
3beta-HSDH 10.8
20alpha-hydroxysteroid dehydrogenase 10.6
prostaglandin F synthase 10.2
cytochrome P-450scc 9.9
hydroxyprostaglandin dehydrogenase 9.8
7alpha-hydroxysteroid dehydrogenase 9.6
heparan sulfate N-deacetylase/N-sulfotransferase 9.4
17-ketoreductase 9.3
3alpha-hydroxysteroid dehydrogenase 9.2
5beta-reductase 9.1
carbonyl reductase 9.1
EC 5.3.3.2 8.9
tropinone reductase 8.9
ecdysone 20-monooxygenase 8.8
dihydrodiol dehydrogenase 8.8
NAD+ synthetase 8.8
25-hydroxyvitamin D3 1alpha-hydroxylase 8.6
20beta-hydroxysteroid dehydrogenase 8.6
GalNAc4S-6ST 8.6
aryl sulfotransferase IV 8.3
steroid sulfotransferase 8.2
SMT1 8.0
5alpha-reductase 7.6
PGE2-9-ketoreductase 7.6
5alpha-reductase 7.6
GPH 7.5
estrogen sulfotransferase 7.4
15-hydroxyprostaglandin dehydrogenase 7.3
GSase 7.3
aspartokinase 7.0
cycloartenol synthase 7.0
lanosterol 14alpha-demethylase 6.9
steroid isomerase 6.9
arylsulfate sulfotransferase 6.9
21-hydroxylase 6.8
estrogen sulfotransferase 6.7
phosphomevalonate kinase 6.7
sterol carrier protein 6.4
CYP7B1 6.3
aldehyde reductase 6.3
nicotinamide mononucleotide adenylyltransferase 6.3
aldehyde reductase 6.3
aldehyde reductase 6.2
phosphoserine phosphatase 6.2
7-dehydrocholesterol reductase 6.1
ferredoxin reductase 6.0
triose-phosphate isomerase 5.7
Lod 5.7
sulfatase 5.5
PDH 5.5
HMG-CoA synthase 5.4
thrombin-activatable fibrinolysis inhibitor 5.3
lysophosphatidylcholine acyltransferase 5.3
citrate lyase 5.2
arylsulfatase 5.0
phenylethanolamine N-methyltransferase 5.0
acetoacetyl-CoA thiolase 4.9
FPS 4.8
sorbitol dehydrogenase 4.8
6-phosphogluconate dehydrogenase 4.8
6-phosphogluconate dehydrogenase 4.8
cathepsin H 4.8
prostaglandin synthetase 4.8
squalene epoxidase 4.7
beta-hydroxybutyrate dehydrogenase 4.7
mevalonate kinase 4.7
diaphorase 4.7
CDR 4.6
PST 4.6
more...
Compound
3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-one 13.3
1-(4-methoxyphenyl)-2-methyl-1-propanone 12.3
alpha-THF 11.6
undecanamide 11.1
7alpha-Methyl-19-nortestosterone 11.0
Lactucin 10.7
6-Hydroxyflavone 10.5
alpha-cortol 10.5
pregn-5-ene-3,20-dione 10.3
Pyridoxal hydrochloride 10.3
Remin 10.3
11-Dehydrocorticosterone 10.3
GDMA 10.1
2-methylcyclopentanone 9.7
Pyridoxine hydrochloride 9.6
C3H7NO2 9.5
Miroestrol 9.4
7H-benzo[c]fluorene 9.1
HPTE 8.9
22R-hydroxycholesterol 8.9
Glycyrrhetinic acid 8.8
androstan-17-one 8.8
diphenyl phthalate 8.8
Promegestone 8.8
dimethyl isophthalate 8.8
androstan-17-one 8.8
diphenyl phthalate 8.8
androstane-3,17-dione 8.7
Glycyrrhetinic acid 8.7
Dicyclohexyl 8.7
Chondroitin sulfate A 8.5
Androstenedione 8.4
4-tert-Octylphenol 8.4
17alpha-hydroxypregnenolone 8.4
Quinalphos 8.3
4-tert-Octylphenol 8.3
Hydroxyflutamide 8.3
2-propyn-1-ol 8.2
Coumestrol 8.2
2-methylcyclohexanone 8.2
2-methylcyclohexanone 8.2
androstan-3-one 8.2
Abietic acid 8.1
2-hydrazinopyridine 8.1
Cosyntropin 8.1
Norethisterone acetate 8.1
2-methylcyclohexanone 8.0
Trey 8.0
Tributyltin chloride 8.0
androstane 8.0
Citronellol 7.9
Allethrin 7.8
Copper chloride 7.7
Pregnenolone 7.7
Glycyrrhizin 7.7
cholestan-3-one 7.7
cholestan-3-one 7.6
Methoxychlor 7.6
dimethyl oxalate 7.6
dicyclohexyl phthalate 7.6
Ethylparaben 7.6
Allopregnanolone 7.6
Daidzin 7.5
Cortisone acetate 7.4
Allopregnanolone 7.4
Echinomycin 7.4
LSD 7.4
androst-4-ene-3,17-dione 7.4
Zwittergent 3-14 7.4
Sodium saccharin 7.4
Androsterone 7.3
dipentyl 7.3
DHC 7.3
Protect 7.2
Linuron 7.2
Triadimefon 7.1
Chenodeoxycholic acid 7.1
Letrozole 7.1
Flavanone 7.1
Troleandomycin 7.0
more...