Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q7LGC8 (HSD)
 3,196 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An enzymologic study of corpora lutea in early pregnant rats treated with abortifacient agents is presented. Prostaglandin F2 alpha treatmen t (500 mcg twice daily 3 or 4 consecutive times) revealed an increase in corpora lutea glucose-6-phosphate dehydrogenase (G6PDH) activity of 110-140% and a moderate increase in 20 alpha-hydroxysteroid dehydrogenas e (20 alpha-HSD), whereas malic enzyme decreased to 27% of control values. Aminoglutethimide treatment (10-20 mg twice daily 6 or 7 consecutive times) revealed decreased G6PDH and malic enzyme activities while 20 alpha-HSD activity was maintained at a very low level. Corpora lutea of these aborted rats revealed moderately active 20 alpha-HSD valu es and slightly higher than control values for G6PDH, whereas malic enzy me activity fell to lower levels. Clomiphene citrate treatment (.5 ml of 3 mg/ml or .5 ml plus .5 ml of 10 mg/ml progesterone) caused abortion within 63 hours postinjection. G6PDH, malic enzyme, and adenosine triphosphate (ATP) citrate lyase activities in these corpora lutea decreased to 66, 68, and 72% of control levels, respectively, while 20 alpha-HSD activity was maintained at a very low level. Activities of 3beta hydroxysteroid dehydrogenase, 6-phosphogluconate dehydrogenase and pyruvate kinase were not appreciably altered. These results indicate that at the beginning of luteolysis and fetal resorption the activities of steroidogenic enzymes decreased and 20 alpha-HSD was not yet activated. Therefore, G6PDH, malic enzyme, and ATP citrate lyase activities could be measured to gauge early changes of luteolysis.
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PMID:An enzymologic study of corpora lutea in early pregnant rats treated with abortifacient agents. 95 39