Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:Q3V6T2 (
ape
)
2,133
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Gastric cancer
is one of the most common malignant tumors and the second leading cause of cancer-related mortality. Elucidating the molecular mechanism underlying the development of
gastric cancer
is crucial in identifying
gastric cancer
-susceptible populations, screening for tumor markers and in the application of gene therapy. This study was conducted to investigate
girdin
expression in
gastric cancer
and para-cancer tissues and to elucidate the role of
girdin
in the development of
gastric cancer
. Tissue micro-array and streptavidin-peroxidase immunohistochemical staining were used to detect
girdin
expression in 105
gastric cancer
and 72 para-cancer tissue samples. Analyses of the patients' clinical and pathological data were also performed. The expression ratio of
girdin
was 40.0% in
gastric cancer
and 11.1% in the para-cancer tissues and the difference was statistically significant (P<0.05).
Girdin
expression was found to be positively correlated (P<0.05) with tumor invasion depth and lymph node metastasis, while no significant associations were found between
girdin
expression and gender, age, tumor size, pathological grade and clinical stage (P>0.05). In conclusion, the upregulation of
girdin
expression in
gastric cancer
may contribute to tumor metastasis and cancer development, suggesting that
girdin
may be a novel indicator for evaluating lymph node metastasis and
gastric cancer
outcome.
...
PMID:Expression and clinical significance of girdin in gastric cancer. 2477 12
