Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q16637 (SMA)
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Human Gene/Protein
CTNNBIP1 protein 11.9
TAOK1 protein 11.9
SMA 11.9
ZNF297B 11.9
PLS3 protein 11.9
regulator of G protein signalling 5 11.9
NRK2 11.9
SMN2 11.5
SMA3 11.4
SMN 11.1
OR52E2 10.9
actin, alpha 2, smooth muscle, aorta 10.9
V-ATPase B2 subunit 10.9
OTU domain-containing protein 4 10.9
GUSBP1 10.9
HCAM1 10.9
C3orf62 10.9
SR-like splicing factor 10.7
neuronal apoptosis inhibitory protein 10.6
bicaudal D homolog 2 10.6
GTF2H2 10.5
Nicotinamide riboside kinase 10.4
CAPN7 10.4
Gemin8 10.2
SMN-interacting protein 1 10.1
SMA4 10.1
survival of motor neuron 10.1
plastin 3 10.0
Serine-threonine kinase receptor-associated protein 10.0
FSP1 10.0
enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase 9.9
tetraspanin 12 9.9
hCD 9.9
F-box protein 31 9.9
CCT-beta 9.9
ACINUS 9.9
SRY-box 7 9.9
Tudor domain-containing protein 3 9.9
HDAC10 protein 9.9
HECTD1 protein 9.9
smooth muscle actin 9.8
chondrolectin 9.8
ZNF444 9.8
hnRNP-R 9.7
alpha-smooth muscle actin 9.7
ZPR1 9.7
GLIPR 9.6
Zinc finger protein A20 9.6
SMAX2 9.6
N-acylsphingosine amidohydrolase 1 9.6
DDX20 9.6
CEP4 9.6
OLF1 9.6
CACNB3 9.6
DP103 9.5
RBM26 9.4
CCT-eta 9.4
relaxin/insulin-like family peptide receptor 1 9.4
Gemin4 9.4
TDRD3 9.4
hnRNP-G 9.4
transcription factor-like nuclear regulator 9.4
LIX1 9.4
RPL22L1 9.4
transcription factor DP-1 9.4
GPR120 protein 9.4
Gemin5 9.3
H326 9.1
MAD4 9.1
P63 protein 9.1
Paired box 2 9.1
RAB6A 9.1
glycerol-3-phosphate acyltransferase, mitochondrial 9.1
NOL10 9.1
NAIP 9.1
Transmembrane protein 88 9.0
BICD2 9.0
RGC-32 9.0
nuclear receptor interaction protein 8.9
NRBP 8.9
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Disease
Combined valvular disease 11.9
SMA II 11.5
Spinal muscular atrophy 11.1
Benign monomelic amyotrophy 10.9
Uterine fibrosis 10.9
SMAX2 10.9
Kugelberg-Welander 10.5
Excessive skin 10.4
Anterior capsule opacification 10.4
Anterior horn cell disease 10.4
SMA4 10.1
Varicose veins of lower extremities 9.9
Subcapsular cataracts 9.9
Infection by Opisthorchis viverrini 9.9
Werdnig-Hoffmann disease 9.9
Renal interstitial fibrosis 9.8
Gastrointestinal stromal sarcoma 9.6
Liver cholestasis 9.6
Metanephric adenofibroma 9.4
Ossifying renal tumor 9.4
ECL cell carcinoid 9.4
Scapuloperoneal spinal muscular atrophy 9.4
Potassium retention 9.4
SMARD1 9.3
Intravascular leiomyomatosis 9.1
Myolipoma 9.1
Giant cell reaction 9.1
Autoimmune myocarditis 9.0
Peritoneal fibrosis 9.0
Renal fibrosis 9.0
Wilkie syndrome 8.9
Bulbar weakness 8.9
Biliary fibrosis 8.8
Hepatic schistosomiasis 8.8
PCH1 8.8
Periodic catatonia 8.8
IGDS 8.6
Verocay body 8.5
Congenital Myasthenic Syndromes 8.5
Cellular angiofibroma 8.4
Secondary biliary cirrhosis 8.4
neuromuscular disorder 8.3
muscular atrophy 8.3
Pleomorphic rhabdomyosarcoma 8.2
Superior mesenteric artery syndrome 8.2
liver fibrosis 8.1
Bile duct proliferation 8.1
Ectopic hamartomatous thymoma 8.1
Hemangioblastoma 8.1
pancreatic fibrosis 8.1
Hidradenomas 8.0
Clear cell tumor 8.0
RMS1 8.0
myxolipoma 8.0
congenital neuromuscular disorder 7.9
Hereditary canine spinal muscular atrophy 7.9
Canalicular adenoma 7.9
Non-occlusive mesenteric ischemia 7.9
Splenic hamartoma 7.9
Glomus tumor 7.8
Pontocerebellar hypoplasia 7.8
Celiac artery compression syndrome 7.8
Myofibroma 7.8
Posterior capsule opacification 7.7
Oral submucous fibrosis 7.6
CMT2D 7.6
Hereditary spastic paraplegia 7.6
Myofibroma 7.5
liver scarring 7.5
PEComa 7.5
Pacheco's disease 7.4
EMA 7.4
pulmonary fibrosis 7.4
Interstitial fibrosis 7.4
Ameloblastic carcinoma 7.2
Mesenteric fibromatosis 7.2
Myoepithelial 7.2
motor neuron disease 7.1
Myofibroblastoma 7.1
connective tissue hyperplasia 7.1
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Symptom
Tongue fasciculations 11.2
Painless hematuria 9.9
Upper motor neuron signs 9.4
Persistent vomiting 8.2
Skin thickening 7.5
cold sweats 7.1
Scratch 6.1
Functional constipation 6.0
Fatigability 6.0
abdominal discomfort 4.5
rectal pain 4.4
weakness 4.4
Involuntary Movement 4.3
asterixis 4.2
hypotonia 4.2
fasciculation 3.9
joint stiffness 3.9
Decreased activity 3.9
lassitude 3.8
excessive sweating 3.8
Stiffness 3.6
abnormal gait 3.4
epigastric pain 3.2
loss of balance 3.1
hyperoxia 3.0
stomach pain 3.0
HSA 3.0
bradykinesia 2.7
partial seizure 2.5
CSR 2.5
flank pain 2.4
thinning 2.4
respiratory distress 2.4
stridor 2.3
colic 2.3
intestinal bleeding 2.3
rigors 2.3
consciousness disturbance 2.3
livedo 2.2
dry eye 2.2
muscle cramps 2.1
hoarseness 2.0
microbial colonization 1.9
hot flashes 1.9
muscle rigidity 1.9
Postoperative pain 1.9
tense 1.9
abdominal pain 1.8
hypoproteinemia 1.8
tremor 1.8
chronic constipation 1.6
nasal discharge 1.5
bitter taste 1.5
myoclonus 1.5
hepatomegaly 1.4
constipation 1.4
despair 1.3
torticollis 1.3
dystonia 1.2
hypocapnia 1.2
exertional dyspnea 1.2
cough 1.1
cyanosis 1.1
dysarthria 1.1
sneezing 1.0
regurgitation 0.9
fever of unknown origin 0.9
spasticity 0.9
functional recovery 0.8
rhinorrhea 0.8
collapse 0.7
back pain 0.7
vomiting 0.7
splenomegaly 0.7
paresthesia 0.7
tachypnea 0.6
masculinization 0.6
numbness 0.6
asthenia 0.6
shoulder pain 0.5
more...
Drug
Maleic Acid 10.1
Camellia oil 8.1
Bendrofluazide 7.5
Bindarit 7.4
Tanespimycin 7.4
Pirfenidone 7.4
Alendronate sodium 7.4
Epalrestat 7.3
Minocin 7.1
Cilengitide 6.8
Ilomastat 6.7
Naftopidil 6.7
Indoprofen 6.6
Diamminedichloroplatinum 6.2
3-Methyladenine 6.1
Rhubarb 5.9
Beraprost sodium 5.9
Sesame oil 5.9
Vinpocetine 5.7
Omniscan 5.6
Treprostinil 5.5
Emodin 5.4
LAAM 5.3
NOV 5.2
Pantopaque 5.2
Liraglutide 5.2
Epigallocatechin 5.1
BLM 5.1
MRC 5.1
Emodin 5.1
TPV 5.1
Valsartan 5.1
Swertia 5.0
ATV 5.0
Podophyllotoxin 4.8
Omniscan 4.8
Avonex 4.8
CCL 4.8
KGF 4.6
Ergosterol 4.6
Swainsonine 4.6
2-Methoxyestradiol 4.6
Artesunate 4.5
CAZ 4.5
PDGF B-chain 4.5
Troglitazone 4.5
APM 4.4
Maraviroc 4.4
Carbenoxolone 4.4
Cilostazol 4.3
Olmesartan 4.2
Verteporfin 4.2
Sorafenib 4.2
Ramipril 4.2
Mesalazine 4.1
DEX 4.1
Frontal 4.1
TMS 4.1
Fluorescein 4.1
Fenoterol 4.0
Angiotensin II 4.0
MTC 4.0
metformin hydrochloride 3.9
AIC 3.9
Pitressin 3.9
Lactase 3.8
ID2 3.8
Gleevec 3.8
Palmitoyl 3.7
CFT 3.7
Nimesulide 3.7
Dasatinib 3.7
Sandostatin 3.7
Sandostatin 3.7
Myricetin 3.7
Sumatran 3.7
GEO 3.7
ROS 3.6
Perindopril 3.6
Simvastatin 3.6
more...
Enzyme
beta-alanine-pyruvate aminotransferase 9.4
carboxypeptidase 1 8.4
creatinine iminohydrolase 7.5
HK2 7.3
PME 6.7
creatininase 6.1
ceramidase 5.5
CYP8B1 5.4
STK2 5.4
AST 5.4
prolyl-tRNA synthetase 5.3
MMP 5.0
GAR 5.0
lysyl hydroxylase 5.0
lysyl oxidase 5.0
glycyl-tRNA synthetase 5.0
aspartate aminotransferase 4.9
matrix metalloproteinase 2 4.8
p80 4.8
guanidinoacetate methyltransferase 4.8
calpain 3 4.7
alanine aminotransferase 4.7
CD10 4.6
proteinase A 4.4
sphingosine kinase 4.4
GD3 synthase 4.4
legumain 4.3
tryptase 4.3
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.3
collagenase 4.3
galactocerebrosidase 4.2
GSK 4.2
calpain 3 4.2
dihydrodiol dehydrogenase 4.1
glutamic dehydrogenase 4.1
inositol 3-kinase 4.1
methylthioadenosine phosphorylase 4.1
AMP-activated kinase 4.1
Rex 4.1
3-mercaptopyruvate sulfurtransferase 4.1
uricase 4.0
PPH 4.0
matrix metalloproteinase 9 4.0
astacin 4.0
NADPH oxidase 4.0
AGT 3.9
NADPH oxidase 3.9
proteinase A 3.9
chymase 3.9
mitogen-activated protein kinase 3.8
ERK 3.7
ALDH 3.7
AMPK 3.7
BMA 3.7
LIS 3.7
dimethylarginine dimethylaminohydrolase 3.7
luciferase 3.7
MEKK1 3.7
interstitial collagenase 3.6
soluble epoxide hydrolase 3.6
endothelin-converting enzyme 3.6
CYP7A1 3.6
PDH 3.5
PNL 3.5
cholesterol oxidase 3.5
type III procollagen 3.5
FPS 3.5
PDO 3.5
gamma-glutamylcysteine synthetase 3.5
focal adhesion kinase 3.5
ornithine aminotransferase 3.4
prolyl hydroxylase 3.4
guanylate kinase 3.4
glycerol kinase 3.4
nicotinamide phosphoribosyltransferase 3.4
MMP-3 3.4
prostacyclin synthase 3.4
myosin light chain kinase 3.3
caspase-1 3.3
TSA 3.3
more...
Compound
Trimethylhydroquinone 11.9
Vitamin U 9.4
6-ECDCA 9.1
LA 96 8.9
8,9-epoxyeicosatrienoic acid 8.8
Aspidin 8.6
Stachydrine 8.4
H IV 8.4
Yangonin 8.4
7-oxabicyclo[2.2.1]heptane 8.2
Yangonin 8.1
Isochlorogenic acid 7.9
HKP 7.9
Chrysophanol 7.8
Hederagenin 7.8
Chrysophanol 7.8
MPPC 7.7
Stachydrine 7.7
JP-2 7.6
Aucubin 7.6
Baccatin III 7.5
1-benzothiophene 7.5
Baccatin III 7.5
Baccatin III 7.5
Micheliolide 7.4
Sennoside A 7.4
Micheliolide 7.4
Helenalin 7.4
DAQ 7.4
Farrerol 7.4
Ginkgolic acid 7.4
Vimentin 7.3
Oxymatrine 7.3
Ponasterone A 7.1
4-aminobenzamide 7.1
Azan 7.1
Acetylshikonin 7.1
ESE 7.0
Boswellic acid 6.9
Patchouli alcohol 6.9
Salvianolic acid A 6.9
Garcinol 6.8
4-phenylbutanoic acid 6.8
Indoxyl sulfate 6.8
dihydrosphingosine-1-phosphate 6.7
Calycosin 6.7
Tributyltin chloride 6.7
Keloid 6.6
1-methylpiperidine 6.5
Papaverine hydrochloride 6.5
Hematoxylin 6.5
Evodiamine 6.4
Ginsenoside Rg1 6.4
Dioxolane 6.4
Evodiamine 6.4
CCl4 6.3
Paxilline 6.3
Hyperoside 6.3
Tetrahydrocurcumin 6.3
Myricitrin 6.3
Aristolochic acid 6.3
Arecoline 6.2
Scoparone 6.2
14,15-DHET 6.2
3-Methyladenine 6.1
Paeonol 6.1
Isoquercitrin 6.1
Picric acid 6.1
Eupatilin 6.1
Maltol 6.1
Collagen 6.1
Nitrofen 6.1
Hinokitiol 6.1
Puerarin 6.1
EGT 6.1
Betulin 6.0
Chrysin 6.0
FAP 6.0
FAP 6.0
Calpeptin 6.0
more...