Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q16637 (SMA)
8,107 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
SMA 8107
collagen 1783
smooth muscle actin 1685
Mol 807
alpha-smooth muscle actin 748
vimentin 596
fibronectin 564
SMN2 497
E-cadherin 489
Sep 483
SMN 431
CD34 330
desmin 320
Smad2 303
Smad3 279
TNF 265
CD31 243
IL-6 209
cytokine 206
type I collagen 178
catenin 169
connective tissue growth factor 144
p38 137
ERK 136
cytokeratin 132
MAPK 126
telomeric 126
ERK1 125
vascular endothelial growth factor 123
p53 122
proliferating cell nuclear antigen 121
caspase-3 117
S100 117
tumor necrosis factor 116
PDGF 113
TGF-beta 112
Ki-67 110
cage 110
AKT 110
calponin 109
matrix metalloproteinase 108
VEGF 108
EMA 107
CD68 106
Vimentin 106
MMP-2 101
PI3K 101
aspartate aminotransferase 101
albumin 100
MMP-9 97
Ang II 95
MRI 94
N-cadherin 88
glial fibrillary acidic protein 88
CTGF 87
angiotensin II 86
Bcl-2 83
CD117 83
c-kit 80
platelet-derived growth factor 78
Smad7 77
STAT3 77
p65 76
EPA 76
alanine aminotransferase 75
NRK 74
JNK 74
AE1 73
HSC 73
neuronal apoptosis inhibitory protein 71
axonal 70
ECM 69
AE3 69
superoxide dismutase 68
TLR4 66
alkaline phosphatase 65
GSH 64
AST 64
mTOR 63
COL1A1 63
more...
Disease
tumor 838
muscular atrophy 625
Spinal muscular atrophy 596
liver fibrosis 591
cancer 508
pulmonary fibrosis 295
carcinoma 167
cirrhosis 141
renal disease 135
diabetes 126
idiopathic pulmonary fibrosis 125
tumor growth 107
EMA 107
neuromuscular disorder 104
motor neuron disease 104
diabetic nephropathy 101
tumor progression 97
hypertension 88
breast cancer 88
hepatocellular carcinoma 86
ischemia 86
asthma 81
myocardial infarction 81
adenocarcinoma 74
hepatitis 70
metastases 69
atherosclerosis 69
Kugelberg-Welander 66
GSH 64
Werdnig-Hoffmann disease 64
proteinuria 58
amyotrophic lateral sclerosis 58
heart failure 53
lung disease 53
Renal fibrosis 52
sarcoma 51
liver disease 51
EMT 50
pancreatic cancer 46
tumorigenesis 44
fatty liver 42
Parkinson's disease 39
glomerulosclerosis 39
chronic liver disease 39
PSS 38
SMA II 38
cornea 38
squamous cell carcinoma 38
stroke 38
chronic renal failure 37
carcinogenesis 37
colorectal cancer 37
chronic hepatitis 36
celiac disease 35
epilepsy 34
liver cancer 34
glioblastoma 33
glioma 33
adenoma 33
lung cancer 32
melanoma 32
hepatitis C 32
renal failure 31
genetic disorder 30
uterus 29
gastrointestinal stromal tumor 29
Blocking 29
chronic pancreatitis 29
obesity 28
hyperglycemia 28
glomerulonephritis 28
gastric cancer 27
scleroderma 26
chronic obstructive pulmonary disease 26
proliferative vitreoretinopathy 25
portal hypertension 25
pancreatic fibrosis 24
coronary artery disease 24
dysplasia 24
MCF 24
more...
Symptom
weakness 197
pain 54
abdominal pain 28
hypotonia 27
respiratory distress 26
seizures 19
anesthesia 19
tremor 16
fatigue 16
thinning 15
vomiting 13
cough 13
collapse 12
hyperoxia 11
abdominal discomfort 10
dyspnea 9
epigastric pain 8
constipation 7
Scratch 7
diarrhea 7
chest pain 6
HSA 6
nausea 6
functional recovery 6
angina 5
starvation 5
back pain 5
dystonia 5
fasciculation 5
colic 4
exhaustion 4
splenomegaly 4
headache 4
regurgitation 4
acidity 4
joint stiffness 4
bradykinesia 4
hepatomegaly 4
stridor 3
Stiffness 3
syncope 3
myoclonus 3
hoarseness 3
discomfort 3
abnormal gait 3
dry eye 3
flank pain 3
Tongue fasciculations 3
discomfort 3
spasticity 3
tense 2
numbness 2
exertional dyspnea 2
hypothermia 2
Decreased activity 2
cyanosis 2
paresis 2
stigma 2
paresthesia 2
anorexia 2
excessive sweating 2
arthralgia 2
ataxia 2
nausea and vomiting 2
distraction 2
analgesia 2
Involuntary Movement 2
Ill 2
dysarthria 2
rigors 1
cerebellar ataxia 1
agitation 1
Functional constipation 1
Welt 1
CSR 1
stomach pain 1
asterixis 1
nasal discharge 1
chronic constipation 1
Postoperative pain 1
more...
Drug
ROS 60
Dermatol 46
Monit 37
MRC 30
Angiotensin II 21
Cardiovasc 18
Asthma 17
Fluorescein 16
lysine 16
BLM 12
CSF 12
ascorbate 11
Pirfenidone 10
TMS 10
CCL 9
Frontal 9
MAP 8
Ethanol 7
Sorafenib 7
Taxol 7
CAM 6
Paraffin 6
Albumin 6
IFN-gamma 6
Gel 6
Portal 6
Emodin 5
Leaf 5
Gleevec 5
Activin 5
GEO 5
IL-2 5
Imatinib 5
Simvastatin 5
Emodin 5
ADM 5
Captopril 5
lactose 5
Valsartan 4
Liraglutide 4
CaCl2 4
Retinoic acid 4
DEX 4
CaCl2 4
Diamminedichloroplatinum 4
Nephron 4
Spectrum 4
CaCl2 4
ABC 4
Vitamin A 4
Nitric Oxide 4
uPA 4
Dial 4
ACT 4
G418 4
Epigallocatechin 4
Nephron 4
NADH 4
Estrogens 3
Bevacizumab 3
TTC 3
Ouabain 3
Bortezomib 3
Spectrum 3
Gelatin 3
p75 3
ATV 3
ALA 3
3-Methyladenine 3
CTX 3
PTC 3
ETS 3
Salbutamol 3
KGF 3
Forskolin 3
Troglitazone 3
Alliance 3
ETA 3
Silica 3
Glycyrrhiza 3
more...
Enzyme
mitogen-activated protein kinase 349
ERK 322
alanine aminotransferase 171
aspartate aminotransferase 163
luciferase 124
focal adhesion kinase 123
superoxide dismutase 103
collagenase 91
protein kinase 90
caspase-3 83
alkaline phosphatase 65
AST 64
CD10 59
peroxidase 47
NADPH oxidase 43
catalase 43
NADPH oxidase 41
MEK 39
renin 39
MMP 35
reverse transcriptase 33
GSK 32
AMP-activated protein kinase 32
proteasome 28
lactate dehydrogenase 28
ACE 27
PARP 24
phosphatidylinositol 3-kinase 23
HK2 22
AMPK 21
AMPK 21
ACS 21
protein kinase C 21
ATPase 18
RNA polymerase 17
matrix metalloproteinase 2 17
glutathione peroxidase 16
trypsin 16
caspase-1 16
calcineurin 15
tryptase 14
phosphoinositide 3-kinase 14
creatine kinase 12
gamma-glutamyl transpeptidase 12
glutathione S-transferase 10
glyceraldehyde-3-phosphate dehydrogenase 10
PME 10
lysyl oxidase 10
thrombin 10
caspase-9 10
transcriptase 9
matrix metalloproteinase 9 9
MMP-3 9
NO synthase 8
glucose oxidase 8
urokinase-type plasminogen activator 7
soluble epoxide hydrolase 7
IKK 7
cdc2 7
myosin light chain kinase 7
lysozyme 7
phosphodiesterase 7
NQO1 6
lipase 6
beta-galactosidase 6
DNA methyltransferase 6
MAP 6
MEKK1 6
NOS 6
uricase 5
prolyl hydroxylase 5
hexokinase 5
heme oxygenase 5
arginase 5
alcohol dehydrogenase 5
phospholipase A2 5
aldehyde dehydrogenase 5
tyrosine hydroxylase 5
RNase 5
RNase 5
more...
Compound
Dec 488
Clin 365
DNA 267
TNF 265
glucose 231
oxygen 221
Collagen 156
creatinine 139
water 137
calcium 118
MTT 107
Vimentin 106
CCl4 101
urea 90
sodium 89
Ang II 88
nitrogen 76
ASA 72
phosphate 69
GSH 65
GSH 65
MDA 64
ANA 60
ANA 60
Hematoxylin 59
ethanol 58
hyaluronic acid 50
nitric oxide 47
arginine 44
tyrosine 41
PEG 39
acetate 38
methionine 37
iron 36
BLM 35
ATP 34
hydrogen 33
salt 32
PEG 30
dUTP 29
zinc 29
MEK 28
cAMP 27
N-acetylcysteine 26
galactose 25
sulfate 25
Angiotensin II 24
PAS 23
phosphorus 23
potassium 23
ALP 23
Cereb 23
CO2 22
STZ 22
Curcumin 22
cysteine 21
ACS 21
ACS 21
iodine 21
proline 21
bromide 20
Cardiol 20
His 20
retinoic acid 19
leucine 18
lysine 18
FAP 17
FAP 17
Neuronal 17
serine 17
vitamin D 17
copper 16
titanium 16
Eosin 16
silver 16
Hydroxyproline 16
Eosin 16
TEM 15
THP 13
nicotinamide 13
more...