Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q16637 (SMA)
 8,107 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
SMA 8107
collagen 1783
smooth muscle actin 1685
Mol 807
alpha-smooth muscle actin 748
vimentin 596
fibronectin 564
SMN2 497
E-cadherin 489
Sep 483
SMN 431
CD34 330
desmin 320
Smad2 303
Smad3 279
TNF 265
CD31 243
IL-6 209
cytokine 206
type I collagen 178
catenin 169
connective tissue growth factor 144
p38 137
ERK 136
cytokeratin 132
MAPK 126
telomeric 126
ERK1 125
vascular endothelial growth factor 123
p53 122
proliferating cell nuclear antigen 121
S100 117
caspase-3 117
tumor necrosis factor 116
PDGF 113
TGF-beta 112
AKT 110
cage 110
Ki-67 110
calponin 109
VEGF 108
matrix metalloproteinase 108
EMA 107
CD68 106
Vimentin 106
aspartate aminotransferase 101
PI3K 101
MMP-2 101
albumin 100
MMP-9 97
Ang II 95
MRI 94
glial fibrillary acidic protein 88
N-cadherin 88
CTGF 87
angiotensin II 86
CD117 83
Bcl-2 83
c-kit 80
platelet-derived growth factor 78
Smad7 77
STAT3 77
p65 76
EPA 76
alanine aminotransferase 75
NRK 74
JNK 74
AE1 73
HSC 73
neuronal apoptosis inhibitory protein 71
axonal 70
AE3 69
ECM 69
superoxide dismutase 68
TLR4 66
alkaline phosphatase 65
GSH 64
AST 64
mTOR 63
COL1A1 63
MCP-1 61
insulin 61
inducible nitric oxide synthase 61
ROS 60
p63 60
CD45 59
PDGFR 59
ANA 59
interleukin-6 58
myosin 58
Desmin 57
Rho 56
CD10 56
transforming growth factor-beta 56
survival of motor neuron 56
RhoA 54
cytokeratin 19 52
lipopolysaccharide 51
MMP9 51
EMT 50
MHC 50
endoplasmic reticulum 50
IL-10 49
plasminogen activator inhibitor-1 49
small nuclear ribonucleoprotein 47
caldesmon 47
scratch 46
CD99 46
osteopontin 46
UTR 45
CD44 45
CK7 45
histone deacetylase 44
smooth muscle myosin heavy chain 44
nestin 43
osteogenic 43
platelet-derived growth factor receptor 43
CK5 43
CD105 42
IL-8 41
vascular endothelium 41
p21 40
transforming growth factor beta 1 40
snRNP 40
kit 40
SOD 40
extracellular signal-regulated kinase 40
renin 39
MMP2 39
SMAD2 38
hepatocyte growth factor 37
bone morphogenetic protein 36
IFN 36
PPAR 36
vWF 36
CD90 36
CCK 35
cyclin D1 35
ACC 35
metalloproteinase 35
She 34
Nrf2 34
peroxisome proliferator-activated receptor 34
histone 34
keratin 34
ATP 34
microsomal 34
K14 34
alternatively spliced 33
MMP 33
catalase 33
ICAM-1 32
GSK 32
GRO 32
CD4 31
CD56 31
gut 31
Slug 31
von Willebrand factor 30
MRC 30
more...
Disease
tumor 838
muscular atrophy 625
Spinal muscular atrophy 596
liver fibrosis 591
cancer 508
pulmonary fibrosis 295
carcinoma 167
cirrhosis 141
renal disease 135
diabetes 126
idiopathic pulmonary fibrosis 125
tumor growth 107
EMA 107
neuromuscular disorder 104
motor neuron disease 104
diabetic nephropathy 101
tumor progression 97
breast cancer 88
hypertension 88
ischemia 86
hepatocellular carcinoma 86
myocardial infarction 81
asthma 81
adenocarcinoma 74
hepatitis 70
atherosclerosis 69
metastases 69
Kugelberg-Welander 66
GSH 64
Werdnig-Hoffmann disease 64
proteinuria 58
amyotrophic lateral sclerosis 58
lung disease 53
heart failure 53
Renal fibrosis 52
liver disease 51
sarcoma 51
EMT 50
pancreatic cancer 46
tumorigenesis 44
fatty liver 42
glomerulosclerosis 39
chronic liver disease 39
Parkinson's disease 39
stroke 38
squamous cell carcinoma 38
cornea 38
PSS 38
SMA II 38
carcinogenesis 37
chronic renal failure 37
colorectal cancer 37
chronic hepatitis 36
celiac disease 35
epilepsy 34
liver cancer 34
glioblastoma 33
adenoma 33
glioma 33
melanoma 32
lung cancer 32
hepatitis C 32
renal failure 31
genetic disorder 30
uterus 29
Blocking 29
chronic pancreatitis 29
gastrointestinal stromal tumor 29
glomerulonephritis 28
hyperglycemia 28
obesity 28
gastric cancer 27
chronic obstructive pulmonary disease 26
scleroderma 26
proliferative vitreoretinopathy 25
portal hypertension 25
pancreatic fibrosis 24
neuroblastoma 24
dysplasia 24
MCF 24
coronary artery disease 24
leiomyosarcoma 24
Duchenne muscular dystrophy 24
pneumonia 23
WT1 23
liver cancer 23
EDA 23
Hypertrophic 23
respiratory failure 23
cataract 23
leiomyoma 23
glaucoma 22
stromal tumors 22
erectile dysfunction 21
pulmonary hypertension 21
anemia 21
cardiovascular disease 20
type 2 diabetes 20
colon cancer 19
SEM 19
familial adenomatous polyposis 19
inflammatory bowel disease 19
neuropathy 19
schistosomiasis 19
renal cell carcinoma 19
Hereditary spastic paraplegia 19
Schistosoma japonicum 18
plaque 18
prostate cancer 18
schwannoma 17
ovarian cancer 17
PEComa 17
primary biliary cirrhosis 17
autoimmune disease 16
TEM 16
cold 16
alcohol abuse 16
colitis 16
interstitial lung disease 16
Renal interstitial fibrosis 16
blindness 16
ISS 15
depression 15
liposarcoma 15
cholangitis 15
leukemia 15
scoliosis 15
TEM 15
SMC 15
aggressiveness 14
chronic active hepatitis 14
nephritis 14
myopathy 14
hemangioma 14
cardiomyopathy 14
bronchopulmonary dysplasia 14
cholestasis 14
vascular disease 14
synovial sarcoma 14
primary tumor 14
HGF 14
Autoimmune hepatitis 14
protein deficiency 14
hyperlipidemia 14
benign tumor 14
Dermal 14
MSA 13
non-small cell lung cancer 13
degenerative disease 13
IgA nephropathy 13
NOD 13
DDP 13
silicosis 13
virus infection 12
renal ischemia 12
BLM 12
Interstitial fibrosis 12
HIV 12
ATM 12
malaria 12
more...
Symptom
weakness 197
pain 54
abdominal pain 28
hypotonia 27
respiratory distress 26
anesthesia 19
seizures 19
fatigue 16
tremor 16
thinning 15
cough 13
vomiting 13
collapse 12
hyperoxia 11
abdominal discomfort 10
dyspnea 9
epigastric pain 8
diarrhea 7
constipation 7
Scratch 7
chest pain 6
functional recovery 6
HSA 6
nausea 6
angina 5
dystonia 5
starvation 5
fasciculation 5
back pain 5
exhaustion 4
splenomegaly 4
bradykinesia 4
regurgitation 4
joint stiffness 4
headache 4
hepatomegaly 4
colic 4
acidity 4
stridor 3
Stiffness 3
syncope 3
dry eye 3
myoclonus 3
abnormal gait 3
flank pain 3
hoarseness 3
Tongue fasciculations 3
discomfort 3
discomfort 3
spasticity 3
tense 2
numbness 2
exertional dyspnea 2
Decreased activity 2
cyanosis 2
paresis 2
dysarthria 2
paresthesia 2
anorexia 2
Ill 2
excessive sweating 2
Involuntary Movement 2
arthralgia 2
analgesia 2
stigma 2
ataxia 2
nausea and vomiting 2
distraction 2
hypothermia 2
rigors 1
cerebellar ataxia 1
agitation 1
Functional constipation 1
Welt 1
CSR 1
stomach pain 1
asterixis 1
nasal discharge 1
chronic constipation 1
Postoperative pain 1
lassitude 1
ophthalmoplegia 1
rhinorrhea 1
Painless hematuria 1
intestinal bleeding 1
despair 1
polyuria 1
loss of balance 1
Fatigability 1
muscle rigidity 1
torticollis 1
bitter taste 1
tachypnea 1
fever of unknown origin 1
rectal pain 1
asthenia 1
flushing 1
hemiplegia 1
hemoptysis 1
hepatosplenomegaly 1
shoulder pain 1
hot flashes 1
partial seizure 1
consciousness disturbance 1
cold sweats 1
microbial colonization 1
vertigo 1
hypoproteinemia 1
Upper motor neuron signs 1
Persistent vomiting 1
livedo 1
muscle cramps 1
masculinization 1
acute pain 1
Skin thickening 1
cachexia 1
sneezing 1
hypocapnia 1
Drug
ROS 60
Dermatol 46
Monit 37
MRC 30
Angiotensin II 21
Cardiovasc 18
Asthma 17
Fluorescein 16
lysine 16
BLM 12
CSF 12
ascorbate 11
TMS 10
Pirfenidone 10
CCL 9
Frontal 9
MAP 8
Sorafenib 7
Taxol 7
Ethanol 7
IFN-gamma 6
Albumin 6
Paraffin 6
Gel 6
Portal 6
CAM 6
Captopril 5
Emodin 5
IL-2 5
Gleevec 5
Imatinib 5
Activin 5
Simvastatin 5
lactose 5
Emodin 5
ADM 5
GEO 5
Leaf 5
DEX 4
Liraglutide 4
Valsartan 4
Retinoic acid 4
CaCl2 4
CaCl2 4
CaCl2 4
Spectrum 4
G418 4
ABC 4
Diamminedichloroplatinum 4
Nitric Oxide 4
Epigallocatechin 4
Vitamin A 4
uPA 4
ACT 4
Nephron 4
Nephron 4
Dial 4
NADH 4
Spectrum 3
Ouabain 3
TTC 3
Gelatin 3
Alliance 3
ETS 3
ATV 3
Salbutamol 3
CTX 3
Estrogens 3
Troglitazone 3
Silica 3
Bevacizumab 3
Bortezomib 3
ALA 3
p75 3
PTC 3
KGF 3
3-Methyladenine 3
ETA 3
CTX 3
Forskolin 3
Glycyrrhiza 3
TAK 2
Heme 2
CFT 2
Parkin 2
Posture 2
ENT 2
caffeine 2
Fructose 2
EE2 2
TiO2 2
NOV 2
Histamine 2
MTC 2
Ramipril 2
Everolimus 2
Vinpocetine 2
Kenyan 2
Ergosterol 2
Rhubarb 2
Cilostazol 2
DBS 2
Maleic Acid 2
ZnO 2
DPA 2
Epalrestat 2
HCG 2
CTC 2
PTH 2
ICI 2
Cilengitide 2
AIC 2
G-CSF 2
TAC 2
Indomethacin 2
NBT 2
Gastro 2
IL-11 2
Swertia 2
Dasatinib 2
CTX 2
Artesunate 2
Parkin 2
CTC 2
Photofrin 2
Vitamin B 2
EPA 1
Lactase 1
Bendrofluazide 1
CPM 1
EPI 1
Alendronate sodium 1
DMAP 1
Dihydrotestosterone 1
2-Methoxyestradiol 1
Erlotinib 1
NH3 1
Carbenoxolone 1
Doxycycline 1
Riboflavin 1
DHT 1
Olmesartan 1
Sandostatin 1
PCB 1
Pantopaque 1
Treprostinil 1
Mesalazine 1
Verteporfin 1
metformin hydrochloride 1
Zoledronic acid 1
Minocin 1
NVP 1
Atropine 1
TPV 1
SBT 1
Ranitidine 1
CTA 1
Acacia 1
Adriamycin 1
nitroglycerin 1
more...
Enzyme
mitogen-activated protein kinase 349
ERK 322
alanine aminotransferase 171
aspartate aminotransferase 163
luciferase 124
focal adhesion kinase 123
superoxide dismutase 103
collagenase 91
protein kinase 90
caspase-3 83
alkaline phosphatase 65
AST 64
CD10 59
peroxidase 47
catalase 43
NADPH oxidase 43
NADPH oxidase 41
MEK 39
renin 39
MMP 35
reverse transcriptase 33
GSK 32
AMP-activated protein kinase 32
lactate dehydrogenase 28
proteasome 28
ACE 27
PARP 24
phosphatidylinositol 3-kinase 23
HK2 22
AMPK 21
ACS 21
protein kinase C 21
AMPK 21
ATPase 18
matrix metalloproteinase 2 17
RNA polymerase 17
trypsin 16
caspase-1 16
glutathione peroxidase 16
calcineurin 15
phosphoinositide 3-kinase 14
tryptase 14
gamma-glutamyl transpeptidase 12
creatine kinase 12
glyceraldehyde-3-phosphate dehydrogenase 10
lysyl oxidase 10
thrombin 10
caspase-9 10
glutathione S-transferase 10
PME 10
MMP-3 9
transcriptase 9
matrix metalloproteinase 9 9
glucose oxidase 8
NO synthase 8
urokinase-type plasminogen activator 7
lysozyme 7
IKK 7
myosin light chain kinase 7
cdc2 7
soluble epoxide hydrolase 7
phosphodiesterase 7
NQO1 6
beta-galactosidase 6
lipase 6
MEKK1 6
MAP 6
DNA methyltransferase 6
NOS 6
transglutaminase 5
alcohol dehydrogenase 5
tyrosine hydroxylase 5
chymase 5
heme oxygenase 5
acetylcholinesterase 5
RNase 5
CD13 5
RNase 5
uricase 5
prolyl hydroxylase 5
hexokinase 5
phospholipase A2 5
aldehyde dehydrogenase 5
arginase 5
PAH 4
acid phosphatase 4
sphingosine kinase 4
choline acetyltransferase 4
ceramidase 4
aldehyde dehydrogenase 4
Rex 4
aldehyde dehydrogenase 4
aldehyde dehydrogenase 4
protein phosphatase 2A 4
aldehyde dehydrogenase 4
gamma-glutamylcysteine synthetase 4
tissue plasminogen activator 4
APC 4
MIP 4
aldose reductase 4
p80 4
TSA 3
enolase 3
CPS 3
AGT 3
glyceraldehyde-3-phosphate dehydrogenase 3
CYP7A1 3
HSD 3
MDR 3
glyceraldehyde-3-phosphate dehydrogenase 3
hyaluronidase 3
P-glycoprotein 3
elastase 3
hyaluronidase 3
thyroid peroxidase 3
interstitial collagenase 3
BMA 3
xanthine oxidase 3
guanylate cyclase 3
demethylase 3
CPT 3
firefly luciferase 3
ADH 3
dihydrofolate reductase 3
glyceraldehyde-3-phosphate dehydrogenase 3
plasmin 3
prostate-specific antigen 3
phosphoglycerate kinase 3
ALDH 3
glyceraldehyde-3-phosphate dehydrogenase 3
cathepsin K 3
Thy1 3
GAR 2
histidine decarboxylase 2
type III procollagen 2
phospholipase C 2
succinate dehydrogenase 2
glutathione reductase 2
urease 2
transpeptidase 2
cholesterol esterase 2
topoisomerase 2
prostaglandin synthetase 2
galactocerebrosidase 2
prostate-specific membrane antigen 2
ornithine aminotransferase 2
complex I 2
glutamate dehydrogenase 2
chaperonin 2
PAM 2
glutamate dehydrogenase 2
adenylate cyclase 2
glycerol kinase 2
PKG 2
indoleamine 2,3-dioxygenase 2
glutamine synthetase 2
PDK1 2
caspase-7 2
CPT 2
PDH 2
more...
Compound
Dec 488
Clin 365
DNA 267
TNF 265
glucose 231
oxygen 221
Collagen 156
creatinine 139
water 137
calcium 118
MTT 107
Vimentin 106
CCl4 101
urea 90
sodium 89
Ang II 88
nitrogen 76
ASA 72
phosphate 69
GSH 65
GSH 65
MDA 64
ANA 60
ANA 60
Hematoxylin 59
ethanol 58
hyaluronic acid 50
nitric oxide 47
arginine 44
tyrosine 41
PEG 39
acetate 38
methionine 37
iron 36
BLM 35
ATP 34
hydrogen 33
salt 32
PEG 30
dUTP 29
zinc 29
MEK 28
cAMP 27
N-acetylcysteine 26
sulfate 25
galactose 25
Angiotensin II 24
phosphorus 23
Cereb 23
PAS 23
ALP 23
potassium 23
Curcumin 22
CO2 22
STZ 22
ACS 21
proline 21
ACS 21
iodine 21
cysteine 21
Cardiol 20
bromide 20
His 20
retinoic acid 19
lysine 18
leucine 18
vitamin D 17
FAP 17
FAP 17
serine 17
Neuronal 17
Eosin 16
Eosin 16
copper 16
Hydroxyproline 16
silver 16
titanium 16
TEM 15
THP 13
nicotinamide 13
formaldehyde 13
DMSO 13
aldosterone 13
THP 13
methanol 13
DDP 13
retinol 12
H2O2 12
Insulin 12
TAA 12
MAD 12
cGMP 12
nickel 12
aldehyde 11
Salt 11
Retinal 11
Panam 11
silicon 11
NAD 10
ADP 10
GPT 10
threonine 10
Keloid 10
SOA 10
Valproic acid 10
CAT 10
ADP 10
CAT 10
palmitic acid 10
CAT 10
ADP 10
GMP 10
CAM 10
NH2 10
8-OHdG 9
5-HT 9
Metformin 9
NADPH 9
methane 9
uridine 9
Silymarin 9
NADPH 9
Metformin 9
NAD 9
Rapamycin 9
DAPT 9
nitrate 9
GTP 9
MIA 9
alanine 9
Resveratrol 9
Estrogen 9
Azan 9
Asp 9
PGE 9
SDS 9
noradrenaline 9
Ascorbic acid 8
AMP 8
PGE2 8
Vitamin D 8
Isoproterenol 8
Paraquat 8
Paraquat 8
gallic acid 8
TNM 8
palmitic acid 8
ASC 8
aldehyde 8
Styrene 7
AICAR 7
DMD 7
GSSG 7
tryptophan 7
Quercetin 7
pyrrolidine 7
DMN 7
MTS 7
Puerarin 7
Cyclosporine 7
more...