Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q16637 (SMA)
 8,107 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present a case of a 14 year old girl with gastrointestinal stromal tumor (GIST) of the stomach. The patient discovered epigastric tumor on palpation. CT and ultrasound revealed tumor arising from the gastric wall, biopsy suggested GIST. Gastroscopically 6 cm policyclic lesion covered by unchanged mucosa has been visualized. Patient was submitted to operative management. There were no features of dissemination or invasion of surrounding structures. Stomach resection according to the Rydygier procedure has been performed. Histologically tumor arose from the muscularis propria. Mitotic activity was high 8/50. Immunohistochemical reaction against CD-117 was positive and in some parts against CD-34 which confirmed GIST. SMA and ALK were negative which excluded myogenic or inflammatory myofibroblastic tumor. Postoperative course was uneventful. There were no indications for adjuvant therapy. No recurrences were observed during follow-up.
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PMID:[Stromal tumor of the stomach in a 14 year old girl]. 1467 1