Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:Q15744 (
C/EBP epsilon
)
82
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Polymorphonuclear leukocytes are essential for host defense to
infectious diseases
.
CCAAT/enhancer binding protein epsilon
(
C/EBP epsilon
) is preferentially expressed in granulocytes and lymphoid cells. Mice with a null mutation in
C/EBP epsilon
develop normally and are fertile but fail to generate functional neutrophils and eosinophils. Opportunistic infections and tissue destruction lead to death by 3-5 months of age. Furthermore, end-stage mice develop myelodysplasia, characterized by proliferation of atypical granulocytes that efface the bone marrow and result in severe tissue destruction. Thus,
C/EBP epsilon
is essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells.
...
PMID:Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein epsilon-deficient mice. 937 21
