Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q14790 (caspase-8)
 8,899 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

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Human Gene/Protein
CASP8 protein 11.8
caspase-8 11.8
caspase and RIP adapter with death domain 11.8
ubiquitin specific protease 47 11.8
TNFRSF6 protein 11.8
EFR3 homolog B 11.8
H2BFM 11.8
Death associated protein 3 11.8
Fas-associated death domain protein 10.9
FADD 10.9
caspase 10 10.8
Sal-like 4 (Drosophila) 10.8
G1/S-specific cyclin E2 10.8
VLIG-1 10.8
DEDD2 10.8
sorting nexin 7 10.8
Apoptotic peptidase activating factor 1 10.8
C4orf22 10.8
FLICE 10.7
c-FLIP 10.7
Bid 10.5
FAS-associated death domain protein 10.4
FLIP 10.2
inhibitor of growth family, member 3 10.2
PTPRK protein 10.2
FLICE-associated huge protein 10.2
EPH receptor B4 10.2
RELL2 10.2
DOPEY1 10.2
APACD 10.2
death effector domain-containing 10.0
TNFR1-associated death domain protein 9.9
DFF35 9.9
FADD protein 9.9
caspase-9 9.9
PMEPA1 protein 9.8
receptor (TNFRSF)-interacting serine-threonine kinase 1 9.8
BAP29 9.8
EFR3B 9.8
RIPK3 9.8
Squamous cell carcinoma antigen 1 9.8
pFIV 9.8
uveal autoantigen with coiled-coil domains and ankyrin repeats 9.8
death receptor 5 9.8
BH3 interacting domain death agonist 9.7
TRAIL-R2 9.6
CASP-9 9.6
Fas-associating protein 9.6
TRADD 9.5
CARD12 9.5
Apoptosis repressor with CARD 9.5
cytochrome c, somatic 9.5
SH3RF2 9.5
GAGE-7 9.5
TNFRSF1A-associated via death domain 9.5
annexin II receptor 9.5
claudin 12 9.5
RIP-1 9.5
apolipoprotein L6 9.5
Phafin-2 9.5
rosbin 9.5
hRFI 9.5
ING3 protein 9.5
RIPK1 9.5
claudin-12 9.4
RIP1 9.4
DcR1 9.4
HIPPI 9.3
CRADD 9.3
TNF receptor-associated protein 9.3
ICH-2 9.3
TNF-related apoptosis-inducing ligand 9.3
MLKL 9.3
TRAIL-R1 9.2
cds2 9.2
G protein-coupled receptor 124 9.2
NEDD5 9.2
RGPR-p117 9.2
TMEM219 9.2
fucosyltransferase 3 9.2
more...
Disease
BRIC2 10.2
HMN7B 9.8
Acute glaucoma 9.1
Reovirus infection 8.6
Coliform mastitis 8.5
Chronic Chagas' disease 8.1
DFNB59 7.9
autoimmune lymphoproliferative syndrome 7.8
methionine synthase deficiency 7.8
AIDS cholangiopathy 7.4
Hypersensitivity syndrome 7.4
CYLD 7.2
Corneal infection 6.9
amok 6.7
FAS 6.6
Geographic atrophy 6.6
AD5 6.6
KRS 6.6
salivary gland adenoid cystic carcinoma 6.6
salivary gland cancer 6.5
Polypoidal choroidal vasculopathy 6.5
Epidermolysis bullosa simplex 6.3
Parasitic infection 6.3
recurrent osteosarcoma 6.3
Extranodal NK/T-cell lymphoma, nasal type 6.3
mouse leukemia P388 6.2
childhood rhabdomyosarcoma 6.2
VED 6.2
salivary gland adenocarcinoma 6.0
colon neoplasm 5.9
Testicular Cancer 5.9
Cytokine storm 5.9
Tumour necrosis 5.9
DFNA5 5.9
cowpox 5.8
Polycystic liver disease 5.7
Epithelioma 5.7
Chronic beryllium disease 5.7
molluscum contagiosum 5.7
AGS 5.7
Canine distemper 5.5
VES 5.4
Metastatic colorectal cancer 5.4
Aspergillus fumigatus infection 5.4
Mucolipidosis type IV 5.3
Neuroblastoma 5.1
Neuroblastoma 5.1
carbuncle 5.1
ileocolitis 5.1
X-linked lymphoproliferative syndrome 5.1
ASM 5.1
MCF 5.0
KCS 5.0
CEM 5.0
acute promyelocytic leukemia 5.0
retinal vascular occlusion 5.0
pediatric solid tumor 4.9
HEP 4.9
DRD 4.9
Oral infection 4.9
MTS 4.9
Barth syndrome 4.8
monocytic leukemia 4.8
adrenal cancer 4.8
closed angle glaucoma 4.8
ED3 4.8
anaplastic thyroid cancer 4.8
Glioblastoma 4.8
myeloid leukemia 4.7
OPA1 4.7
colon cancer 4.7
Askin tumor 4.7
Inverted papilloma 4.7
Vesicular stomatitis 4.7
Photosensitization 4.7
cancer regression 4.6
Acute liver failure 4.6
LGL leukemia 4.6
B-cell lymphoma 4.6
RP3 4.6
more...
Symptom
loss of equilibrium 4.7
bradypnea 4.2
hyperemesis 3.6
Tenderness 3.3
loss of balance 3.0
hyperoxia 2.9
skin damage 2.8
ataxic gait 2.7
collapse 2.7
halitosis 2.6
dry eye 2.0
splenomegaly 1.9
hot flashes 1.7
starvation 1.6
memory loss 1.6
nasal discharge 1.4
sore throat 1.4
cachexia 1.3
hypothermia 1.3
menopausal symptoms 1.1
functional recovery 1.1
exhaustion 0.4
thinning 0.3
HSA 0.3
bone pain 0.2
insomnia 0.0
hepatosplenomegaly -0.3
acute stress -0.4
diarrhea -0.4
respiratory distress -0.5
seizures -0.6
hepatomegaly -0.7
hypotonia -0.7
back pain -0.8
myalgia -0.9
tinnitus -0.9
spasm -1.0
weakness -1.1
dystonia -1.2
tremor -1.4
syncope -1.4
nausea and vomiting -1.4
dizziness -1.4
low back pain -1.5
nausea -1.7
sleepiness -1.8
erythema -1.9
overweight -1.9
dyspnea -2.0
acidity -2.1
abdominal pain -2.1
ataxia -2.2
headache -2.4
angina -2.6
anesthesia -2.6
discomfort -2.6
discomfort -2.8
pain -3.0
vomiting -3.2
Drug
Edratide 11.8
Lexatumumab 9.2
2-Iminobiotin 9.2
Alexidine 8.8
Zedoary 8.5
Mapatumumab 8.5
Bear bile 8.3
Methadone hydrochloride 8.3
Cupric sulfate 7.8
Citrus unshiu peel 7.7
Naftopidil 7.5
Mevastatin 7.4
Radicicol 7.3
Flavopiridol 7.3
Epothilone B 7.3
2-Methoxyestradiol 7.2
Avasimibe 7.2
Motexafin gadolinium 7.1
Sodium ascorbate 7.1
Berberine chloride 7.1
Irofulven 6.9
Revlimid 6.7
Lonafarnib 6.6
CA-074 6.6
Ilomastat 6.6
Bucillamine 6.5
Bortezomib 6.3
Peridinin 6.3
Olomoucine 6.3
Hyperforin 6.3
Trabectedin 6.2
Nafamostat mesilate 5.8
Dextran sulfate sodium 5.8
Tipifarnib 5.7
Zebularine 5.7
Vorinostat 5.7
Cilengitide 5.6
CED 5.6
Arsenic trioxide 5.6
Alimta 5.5
Swainsonine 5.4
Rasburicase 5.4
Batimastat 5.3
Batimastat 5.3
ROS 5.3
Mizoribine 5.2
Ddc 5.2
Tranilast 5.1
Onconase 5.1
Epigallocatechin 5.0
Compound 18 5.0
Intron A 5.0
Sesamol 5.0
Emodin 4.9
Dasatinib 4.9
Thioridazine 4.9
PFT 4.9
Compound 15 4.9
Etodolac 4.8
Etoposide 4.8
Cantor 4.8
Glycyrrhiza 4.8
Propidium 4.8
Intron A 4.8
Intron A 4.7
DPE 4.7
RBT 4.7
ID2 4.7
Emodin 4.6
Acitretin 4.6
p75 4.6
3-Methyladenine 4.4
AMC 4.4
Artesunate 4.4
Bromelain 4.4
Taxol 4.3
Oxaliplatin 4.3
Agomelatine 4.3
ADR 4.3
Casodex 4.2
more...
Enzyme
caspase-8 11.8
caspase-10 11.1
caspase-10 11.1
caspase-9 9.9
caspase-2 9.5
caspase-6 9.5
caspase-6 9.5
caspase-2 9.4
caspase-7 9.2
caspase-7 9.1
caspase-4 8.9
caspase-4 8.8
caspase-3 8.3
caspase-11 8.3
caspase-11 8.3
caspase-5 8.2
caspase-5 8.1
PARP 7.7
lombricine kinase 7.6
Omi/HtrA2 7.6
caspase-1 7.1
AO1 6.6
adamalysin 6.5
neutral sphingomyelinase 6.1
TdT 6.1
granzyme B 5.8
DIPP 5.8
deoxyhypusine hydroxylase 5.8
10-formyltetrahydrofolate dehydrogenase 5.7
3-hydroxy-3-methylglutaryl-CoA lyase 5.5
sphingomyelin synthase 5.5
lysyl-tRNA synthetase 5.3
IKK 5.2
mu-calpain 5.2
m-calpain 5.1
PTR1 5.1
ECH 5.1
aspartase 5.1
glutaryl-CoA dehydrogenase 5.1
cathepsin B 5.0
ceramidase 5.0
cdc2 4.9
mitogen-activated protein kinase 4.9
p100 4.8
sphingosine kinase 4.6
arachidonate 5-lipoxygenase 4.6
deoxyhypusine synthase 4.5
MMP 4.5
pseudouridine synthase 4.5
kynurenine aminotransferase 4.4
CYP46A1 4.4
phosphatidylinositol 3-kinase 4.3
NAO 4.3
GD3 synthase 4.3
cathepsin D 4.3
kynurenine 3-monooxygenase 4.2
proteasome 4.2
MEK 4.2
cathepsin C 4.2
legumain 4.2
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.2
HCS 4.1
farnesyltransferase 4.1
DNase II 4.1
protein phosphatase 2A 4.1
PDK1 4.0
inositol 3-kinase 4.0
GSK 3.9
DNA ligase 3.8
DNA ligase 3.8
farnesyltransferase 3.8
coproporphyrinogen oxidase 3.8
phosphoinositide 3-kinase 3.8
ribonucleotide reductase 3.8
TACE 3.8
MPP 3.7
proline oxidase 3.7
ribonucleotide reductase 3.7
HK2 3.7
TSP-1 3.7
more...
Compound
estra-1,3,5(10)-trien-17-ol 11.8
4-chloro-N-methylbenzamide 10.8
Defenuron 10.8
Justicidin A 10.5
24-Hydroxycholesterol 10.2
C14H21N3O2 10.2
Glucoraphenin 10.2
C14H21N3O2 10.2
C14H21N3O2 10.2
C14H21N3O2 10.2
Cephalochromin 10.2
C14H21N3O2 10.2
Lupulone 10.0
C14H21N3O2 9.8
Codeinone 9.8
Sarcophine 9.8
Kinetin riboside 9.8
Dihydrosanguinarine 9.8
Cephalostatin 1 9.6
C14H21N3O2 9.5
Tigogenin 9.5
Kinetin riboside 9.5
Decylubiquinone 9.5
2-hexadecanol 9.5
Valtrate 9.5
C14H21N3O2 9.5
Saucernetin 9.5
alpha-Santalol 9.2
2,5-Dihydroxyacetophenone 9.2
Gartanin 9.2
C14H21N3O2 9.2
Raddeanin A 9.1
Linoelaidic acid 9.0
methyl 2-benzoylbenzoate 9.0
Deltonin 9.0
C14H21N3O2 8.8
1-pyrrolidinecarbodithioic acid 8.8
Sinularin 8.8
androst-2-en-17-one 8.8
Rocaglamide 8.7
hydroxymethylphosphonic acid 8.6
PHPS 8.6
Didodecyldimethylammonium bromide 8.6
Bufotalin 8.5
2,4-dimethylpyridine 8.5
Dihydrochalcone 8.5
Nomilin 8.5
Poncirin 8.5
N-hydroxybutanamide 8.5
Tectochrysin 8.5
2-hydroxy-1-propanesulfonic acid 8.3
Chelidonine 8.3
Diospyrin 8.3
cis-Jasmone 8.3
7-Ketocholesterol 8.3
Dicentrine 8.2
3,4-dimethylpyridine 8.2
N-hydroxybutanamide 8.2
Tricetin 8.1
taurolithocholate 3-sulfate 8.1
Bullatacin 8.1
Ginkgetin 8.1
Piperlonguminine 8.0
Morphinone 8.0
THBP 8.0
Methadone hydrochloride 8.0
Eupatorin 8.0
Harmol 7.9
Ovatodiolide 7.9
2-oxopropanamide 7.9
Ammonium pyrrolidine dithiocarbamate 7.8
Phytosphingosine 7.8
Decursin 7.7
Potassium oxonate 7.6
Ver A 7.6
Isofraxidin 7.6
Cedrol 7.6
N-hydroxybenzamide 7.6
Decursinol 7.5
Borrelidin 7.4
more...