Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Combination chemotherapy with CHOP (cyclophosphamide, Adriamycin, vincristine, and prednisone) and HOP (Adrimycin, vincristine, and prednisone, was used as treatment for patients with pathologically staged, advanced non-Hodgkin's lymphoma. Among 204 evaluable patients treated on CHOP there were 71% complete remissions with 92% overall responses. Among the 216 evaluable patients on HOP there were 61% complete remissions and 88% responses. Complete remission rates among patients with histiocytic lymphoma were comparable to those of patients with lymphocytic disease. Patients with nodular lymphoma had higher rates of complete remission than their counterparts with diffuse lymphoma. This was noted with both CHOP (78% vs. 67%) and HOP (67% vs. 60%) induction therapy. Rapid responses were common, as more than 14% of complete remissions and 66% of overall responses were achieved with the first course of treatment. Patients in complete remission have been maintained with either cyclophosphamide, vincristine, and prednisone (COP) or arabinosyl cytosine, vincristine, and prednisone (OAP). After 1 year, 86% of patients on COP and 80% on OAP are projected to be free of disease.
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PMID:Hydroxyldaunomycin (Adriamycin) combination chemotherapy in malignant lymphoma. 79 73

Non-Hodgkin's lymphomas was considered an incurable disease 20 years ago, but it is now possible to administered intensive combination chemotherapy thanks to the development of new anticancer agents and the sophistication of their administration, making it possible to increase both the complete response rate and the 2-year survival rate to more than 80%. The outcome is that more than 50% of cases are now curable. One significant feature of non-Hodgkin's lymphoma in Japan is the fact that the prevalence of T-cell lymphomas, which is unfavorable, is higher than in Western nations. A check of the survival time of non-Hodgkin's lymphomas between the five years ending in 1970 and those beginning in 1971 indicates that it was significantly extended. In cases to which BACOP, HOP and other agents were concurrently administered during the initial course of treatment, the complete response rate increased over 70%, and the median survival time at 45 months, making it possible to hopes on the future development of chemotherapy.
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PMID:[Chemotherapy of malignant lymphoma, with special regard to non-Hodgkin's lymphomas]. 187 Feb 61