Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A pathological study was carried out on 124 cases of primary gastric non-Hodgkin's lymphoma (NHL) in Japan. Macroscopically the cases were divided into three groups; flat, polypoid, and ulcerative types. Early lymphomas were distinguished from advanced by the depth of infiltration. Histologically the commonest type was ML, immunoblastic (ML, ibl.). Most were high grade malignancy, in terms of morphology. Lymph node involvement was found in 44 cases. Correlation between macroscopical appearance, histological diagnosis, stage and accompanying reactive lymphoid hyperplasia (RLH) was studied. Three main prototypes of gastric NHL were noted: The first was macroscopically ulcerative type, histologically high grade malignancy and lacked RLH; the second was mostly flat, ML, lymphoplasmacytic/lymphoplasmacytoid (ML, l-p.) or ML, ibl., associated with RLH, and arose from neoplastic proliferation of the interfollicular lymphoid cell in RLH (termed gastric NHL of interfollicular type); the third was mostly flat, ML, centroblastic (ML, cbl.) or lymphoblastic (ML, lbl.), associated with RLH, and originated from neoplastic proliferation of the follicular center cell in RLH (gastric NHL of follicular type).
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PMID:Primary gastric non-Hodgkin's lymphomas in Japan. 311 60

The classification of CD5-negative/CD10-negative chronic B-cell leukemias (CD5-/CD10- CBL) can be problematic. Most of these cases may represent leukemic non-Hodgkin's lymphoma (NHL) other than B-cell chronic lymphocytic leukemia (BCLL); nonetheless, some investigators still advocate the term "CD5-negative BCLL." Because adhesion molecule (AdMol) expression patterns reflect the biology of lymphoid neoplasms, we studied a series of 106 B-cell lymphoproliferative disorders, including CD5+ BCLL (n = 56), NHL other than BCLL (n = 35), and CD5-/CD10- CBL (excluding hairy cell leukemia and prolymphocytic leukemia) with no prior history of NHL (n = 15) for expression of components of the very late antigen-4 complex (alpha4/beta1 integrin (CD49d/CD29)), components of the mucosal addressin-cell adhesion molecule receptor (alpha4(CD49d)/beta7 integrin), and L-selectin (CD62L). CD62L expression was significantly greater in CD5+ BCLL than in NHL (P < .001). Conversely, CD29, CD49d, and beta7-integrin expression were significantly greater in NHL than in CD5+ BCLL (P < .001 for each marker). These differences persisted when only blood and bone marrow samples were analyzed, with the exception of differences in CD62L expression, which approached, but did not reach, statistical significance (P = .08). The group of CD5-/CD10- CBL displayed an AdMol profile similar to NHL and was significantly different than CD5+ BCLL in expression of beta7 integrin, CD29, CD49d, and CD62L (P range < .001-.011). In summary, CD5-/CD10- CBL display an AdMol profile resembling NHL and significantly different from CD5+ BCLL, supporting the growing notion that "CD5-negative BCLL" generally represents leukemic NHL rather than a variant of true CD5+ BCLL.
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PMID:Adhesion molecule expression in CD5-negative/CD10-negative chronic B-cell leukemias: comparison with non-Hodgkin's lymphomas and CD5-positive B-cell chronic lymphocytic leukemia. 1117 97