Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In order to estimate the clonality of B-cell lymphoproliferative disorders, polymerase chain reaction (PCR) was used to detect the Ig heavy chain gene rearrangement in DNA extracted from formalin-fixed and paraffin-embedded bone marrow biopsies. 16 out of 19 cases (84%) of B-CLL (n = 9), multiple myeloma (n = 7) and B-non-Hodgkin's lymphoma (n = 3) showed sharp monoclonal bands, while polyclonal smears or no PCR-products were observed in non-neoplastic bone marrow or AML specimens. The results showed that the DNA from paraffin-embedded bone marrow biopsies could be used to detect monoclonal IgH rearrangement by PCR method. This forms the basis for the studies of minimal residual disease or B-ML bone marrow infiltrated diseases.
Hua Xi Yi Ke Da Xue Xue Bao 1994 Dec
PMID:[Detection of B-cell clonality in paraffin-embedded bone marrow biopsy specimens by polymerase chain reaction]. 774 82

A clinicopathological study of 304 cases of malignant lymphomas (ML) in children in Sichuan province is reported. One hundred and sixty of them were Hodgkin's disease (HD). The ratio between males and females was 5.7 to 1. The disease was more prevalent in children aged from 5 to 9. Cervical lymph nodes were more easily involved. Extra-nodal HD wasn't found in these cases. When subtypes of HD were concerned 62.5% of cases belonged to mixed-cellularity HD. The prognosis of HD was better than that of non-Hodgkin's lymphoma (NHL). The remaining 144 cases were NHL. The ratio between males and females was 3.4 to 1. The disease was more prevalent in children aged from 4 to 14. Eighty four percent of NHL primarily originated from superficial lymph nodes and the other 16.0% of NHL was of extranodal involvement. Seventy two point nine percent of cases in this group was of high grade malignancy. Among them the lymphoblastic type of NHL occupied 44.5%. On the other hand, the follicular type of NHL was rare (0.7%). The specialities of malignant lymphomas in childhood in China are also discussed in the present report.
Hua Xi Yi Ke Da Xue Xue Bao 1994 Mar
PMID:[Malignant lymphomas in childhood in Sichuan province--a clinicopathological analysis of 304 cases]. 807 Jul 84

The expression of P16 protein was examined in 45 cases of non-Hodgkin's lymphoma (NHL), 4 cases of reactive hyperplasia of lymph node (RHLN) and 6 cases of normal spleen with immunohistochemical staining. Positive reaction of P16 protein was observed in some lymphocytes of RHLN and splenic nodule and around splenic sinus. The positive rate of P16 protein expression in NHL was 37.8% (17/45). The positive rates of P16 protein expression for the low intermadiate- and high-grade malignancy groups were 66.7% (10/15), 37.5% (6/16) and 7.1% (1/14) respectively. There was a significant difference between the low malignancy NHL and the high malignancy NHL (P < 0.005) in expression rate of P16 protein. It suggests that P16 protein expression may be one of the important parameters in estimating the prognosis of patients with NHL.
Hua Xi Yi Ke Da Xue Xue Bao 1996 Sep
PMID:[The relationship of non-Hodgkin's lymphoma with P16 protein expression]. 938 56