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Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum copper levels (SCL) which are concomitantly related to red blood cell free copper are significantly increased in some malignant lymphomas in the phase of activity. This results in a profound inhibition of red cell key glycolytic enzymes, hexokinase (Hx) being the most sensitive. Fifteen patients (eight with Hodgkin's disease and seven with non-Hodgkin's lymphoma) were studied for serum and red cell copper concentrations and Hx activity. The mean red cell life span was determined using 51Cr labelled red cells. The resulting data shows that in active disease an increase in SCL was associated with a decrease in Hx activity and a shortened red cell survival. In these cases there was no evidence of autoimmune phenomena or of direct bone marrow involvement by the disease. It is suggested that the increase in copper levels results in a shortened red cell life span through a copper-induced inhibition of red cell Hx.
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PMID:Metabolic changes in red blood cells in malignant lymphomas. 46 59

The serum levels of Ceruloplasmin (CER), Properdin Factor B (PFB) and Copper (CU) were evaluated in a series of 40 patients with Hodgkin's Disease and 46 patients with non-Hodgkin's lymphoma. Concentrations of CER and PFB were determined by rate nephelometry and CU concentrations by the bathocuproine colorimetric method. The results obtained demonstrated that CER, together with the well documented CU, can be used for monitoring Hodgkin's Disease.
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PMID:Serum levels of ceruloplasmin, properdin factor B and copper in lymphoma patients. 179 12

A capillary gas chromatographic method with nitrogen-phosphorus detection for the determination of N-acetylisoputreanine-gamma-lactam (acisoga) in urine is described. The method was validated by comparing the results with those given by an isotope dilution mass fragmentographic method. Making use of specific inhibitors for copper-dependent amine oxidase and polyamine oxidase in rats, it was demonstrated that acisoga is formed by oxidative deamination of N1-acetylspermidine by the former enzyme. Moreover, acisoga is not a substrate for pig liver polyamine oxidase. Increased concentrations of acisoga, relative to N1-acetylspermidine, in urines of patients with non-Hodgkin's lymphoma indicated that this conversion diminishes the sensitivity of N1-acetylspermidine as a marker for (tumour) cell death.
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PMID:Gas chromatographic determination of N-acetylisoputreanine-gamma-lactam, a unique catabolite of N1-acetylspermidine. 206 74

An analysis of prognostic variables was performed in a retrospective study of 121 patients with Ann Arbor stage I-II head and neck non-Hodgkin's lymphoma admitted from 1973 to 1988. The overall actuarial 5-year survival rate was 58.8% and the minimum follow-up 15 months. Nine clinical and laboratory parameters were studied, including serum lactic dehydrogenase (LDH) and serum copper (SCL), and subjected to univariate and multivariate analyses. In univariate analysis, histology and LDH were found to be significant prognostic variables. Evaluation by Cox's multivariate proportional hazard model revealed histology, SCL and sex to be of prognostic significance.
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PMID:Prognostic factors in head and neck non-Hodgkin's lymphoma with special reference to serum lactic dehydrogenase and serum copper. 226 Dec 2

Zinc status and the effect of zinc supplementation were assessed in groups of patients with non-Hodgkin's lymphoma and Hodgkin's disease; patients were either untreated or in remission. In the patients in remission, plasma zinc was normal; and whereas 30% of untreated patients had low plasma zinc, the group as a whole did not differ from normal. For mononuclear cell zinc, the range of values in the disease group was far wider than in controls, but there was no significant difference between the means of the groups. Granulocyte zinc was significantly lower in both the groups of patients in remission from non-Hodgkin's lymphoma and Hodgkin's disease compared with the control group. Significant increases were found in the plasma copper, ceruloplasmin, and the copper-to-zinc ratio in several of the patient groups. Plasma zinc increased by 23% with zinc supplementation (50 mg elemental Zn/day), but there was no effect on mononuclear cell or granulocyte zinc. Apart from granulocyte zinc, there is little evidence of zinc deficiency in non-Hodgkin's lymphoma or Hodgkin's disease. However, the presence of depleted granulocyte zinc levels could modify the immune function of this cell population.
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PMID:Leucocyte zinc in non-Hodgkin's lymphoma and Hodgkin's disease. 336 23

Between 1975 and 1981, 29 children with Hodgkin's disease, 22 with non-Hodgkin's lymphoma, and 13 with lymphadenopathy from various nonmalignant causes were studied with respect to the usefulness of serum copper, ceruloplasmin, and erythrocyte sedimentation rate (ESR) as markers of disease activity. Although elevated copper and ceruloplasmin levels were indicators of disease activity in the childhood lymphomas, and in patients with Hodgkin's disease the levels tended to be higher in those with advanced clinical stage, they were no better markers of disease activity than the ESR. Moreover, elevated serum copper and ceruloplasmin were nonspecific, since one child with benign lymphadenopathy and one Hodgkin's disease patient with an infection had raised levels. Low levels of copper and ceruloplasmin were found in four jaundiced patients probably because of impaired hepatic synthesis of ceruloplasmin. The authors conclude that serum copper and ceruloplasmin levels are no better markers of disease activity in children with lymphomas than is the ESR.
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PMID:Serum copper, serum ceruloplasmin, and erythrocyte sedimentation rate measurements in children with Hodgkin's disease, non-Hodgkin's lymphoma, and nonmalignant lymphadenopathy. 397 43

Lymph node and spleen tissues involved in malignant lymphomas were analysed for iron, manganese, copper, zinc and magnesium by atomic absorption spectrophotometry. The levels of iron are found to be significantly lower in the case of Hodgkin's lymphoma compared with non-Hodgkin's lymphoma and normal lymph nodes. However, they are elevated in Hodgkin's lymphoma when compared with the normal value for spleen tissues. Magnesium is significantly higher in lymph nodes of non-Hodgkin's lymphoma compared with Hodgkin's lymphoma and normal values, but is not altered significantly in spleen tissues. The distribution of the other elements examined is not altered significantly in malignant lymphomas. The importance of the in situ levels of these elements to NMR imaging is discussed.
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PMID:Iron, zinc, copper, manganese and magnesium in malignant lymphomas. 400 19

Levels of copper, haptoglobin, fibrinogen and Factor VIII were measured in 30 patients with non-Hodgkin's lymphoma on 90 occasions in an attempt to demonstrate a possible correlation between hypercupremia and other acute phase reactants. The four parameters were measured simultaneously in active disease and in remission. The serum copper, along with other parameters, was significantly elevated in the active disease (P less than 0.001) and there was a high correlation between the levels of serum copper, fibrinogen and haptoglobin (P less than 0.001).
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PMID:Correlation of hypercupremia with other acute phase reactants in malignant lymphoma. 640 95

A study of 306 serum copper levels (SCL) determinations in 115 patients with non-Hodgkin's lymphoma indicates a positive correlation between SCL and the state of disease. Patients with advanced disease (Stages II, III and IV) before treatment, those with active disease while under treatment, or in a relapse had a significantly higher SCL than patients in Stage I or those with no evidence of disease (NED). The mean SCL of patients with Stage I was similar to that of patients with NED. The mean values of these two groups did not differ significantly from that of healthy controls. Histological subtypes, according to the Rappaport classification, has no influence on SCL. Grouping into nodular versus diffuse lymphoma, histiocytic versus lymphocytic lymphoma and favorable versus unfavorable histology failed to demonstrate a difference between the groups. Within each subset a wide range of SCL was evident. However, good correlation was observed with the degree of disease activity. SCL may provide a useful parameter for patient monitoring. In this series, however, SCL was not useful for the prediction of an early relapse.
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PMID:The value of serum copper levels in non-Hodgkin's lymphoma. 669 11

40 patients, 15 females and 25 males, with biopsy-proven non-Hodgkin's lymphoma within the age range of 2-16 years were included in this study. The mean serum zinc level in 38 untreated patients was 78.95 +/- 18.80 microgram % and significantly lower than in controls (p less than 0.001). The mean serum copper level in 40 untreated patients was 205.32 +/- 49.44 microgram % and significantly higher than in controls (p less than 0.001). The mean copper/zinc ratio in these patients was 2.75 and was found to be significantly higher than in controls (p less than 0.01). Copper levels were lower during remission (p less than 0.05). Our data indicate that serum copper levels and the copper/zinc ratio might be indicators for disease activity in children with non-Hodgkin's lymphoma.
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PMID:Serum copper and zinc levels and copper/zinc ratio in pediatric non-Hodgkin's lymphoma. 680 Feb 4


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