Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rituximab (RTX), a monoclonal antibody (mAb) against CD20, has been widely used for lymphoma therapy. RTX in combination with cyclophosphamide /doxorubicin /vincristine /prednisone (R-CHOP) remains the standard frontline regimen for diffuse large B-cell lymphoma. However, suboptimal response and /or resistance to rituximab have remained a challenge in the therapy of B-cell non-Hodgkin's lymphoma (NHL). Novel agents are under active clinical trials. This review will summarize the latest development in new mAbs against CD20, which include second-generation mAbs, ofatumumab, veltuzumab (IMMU-106), ocrelizumab (PRO70769), and third-generation mAbs, AME-133v (ocaratuzumab), PRO131921 and GA101 (obinutumumab).
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PMID:Novel CD20 monoclonal antibodies for lymphoma therapy. 2305 66

Primary hepatic lymphoma (PHL) is a lymphoma presenting with predominant liver involvement at presentation in the early stage of lymphoma. It accounts to less than 0.4% of all extranodal lymphomas and usually occurs in immunocompromised states. It is more commonly of the non-Hodgkin's lymphoma of B cell variety. Hodgkin's lymphoma presenting as PHL has not been reported before. We report a 55-year-old HIV positive male presenting with an SOL in left lateral segments of liver having typical imaging characteristics of fibrolamellar HCC with normal serum AFP levels. Surgical resection was done and the histopathological analysis and immunohistochemistry of the specimen revealed it to be a Hodgkin's lymphoma. The patient was started on chemotherapy (ABVD regimen) along with highly active antiretroviral therapy (HAART). Primary lymphoma of liver can mimic HCC on imaging. Hence, in the background of an immunocompromised state like HIV with normal serum AFP levels, PHL should be suspected and liver biopsy can clinch the diagnosis.
AME Case Rep 2018
PMID:Primary Hodgkin's lymphoma of liver in HIV-a case report and review of literature. 3026 17

Although renal involvement is common in non-Hodgkin's lymphoma (NHL), primary renal NHL is a rare disease. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of NHL and is responsible for 30-40% of adult NHL cases globally. Here, we present a case of a 68-year-old man with right flank pain who underwent retroperitoneal laparoscopic radical nephrectomy for an enlarged right kidney, with evidence of an infiltrating mass. Postoperative histopathological examination revealed primary renal DLBCL. Primary renal lymphoma (PRL) is quite rare, and clinicians should try to ensure early diagnosis and treatment with standardized and systematic chemotherapy.
AME Case Rep 2020
PMID:Primary renal lymphoma: a case report and review of the literature. 3242 May 31