Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rare primary endobronchial malignancies were diagnosed in four adolescents: atypical bronchial carcinoid, mucoepidermoid carcinoma, bronchogenic (squamous cell) carcinoma, and non-Hodgkin's lymphoma. Metastatic disease was evident in each case. Three of the four patients died within one year of diagnosis. This paper describes each of these entities, illustrates their plain film and CT abnormalities (bronchial "cut-off", hilar mass, local congestive edema, lobar collapse, hyperinflation), and discusses the utility of CT in their diagnosis.
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PMID:Malignant endobronchial lesions of adolescence. 133 2

Anaplastic large cell Ki-1 lymphoma is an uncommon type of non-Hodgkin's lymphoma that rarely presents primarily in the bone. Three such cases are reported. All patients were young and had bone pain; one had paraparesis as a complication of collapse of the thoracic vertebral body. The involvement was either monostotic or polyostotic. Radiologically, the lesions were lytic and had ill-defined borders. Histologically, the large neoplastic cells had pleomorphic bizarre nuclei, prominent nucleoli, abundant deeply amphophilic cytoplasm, and paranuclear pale hof. They were admixed with variable numbers of inflammatory cells. One case each was of T-cell, B-cell, and non-T non-B lineage. All three cases showed excellent responses to chemotherapy with or without radiation therapy. Recognizing the lymphomatous nature of this highly pleomorphic tumor is important because of its potential curability with appropriate chemotherapy.
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PMID:Anaplastic large cell Ki-1 lymphoma of bone. 165 5

Pediatric patients presenting with anterior mediastinal masses between January 1980 and November 1988 were reviewed to assess the correlation between tracheal cross-sectional area and anesthetic risks. Forty-two patients had evaluable computed tomography (CT) scans and underwent a surgical procedure. Thirty-four patients had Hodgkin's disease, six had non-Hodgkin's lymphoma, and two had mediastinal teratoma. Tracheal cross-sectional areas were greater than 75% of expected in 19 cases, greater than 50% to 75% in 16 cases, greater than 25% to 50% in five cases, and less than or equal to 25% in two cases. The presence or extent of symptoms did not correlate well with the degree of tracheal narrowing shown by CT scan except for orthopnea. Local anesthesia was used primarily in patients with significant tracheal narrowing (tracheal size was less than or equal to 56% in 5 of 6 patients). General anesthesia with spontaneous ventilation by mask was performed in four patients with tracheal areas of 33%, 73%, 76%, and 98% of expected. General endotracheal anesthesia was utilized in the remaining 32 patients, only three of whom had tracheal areas of less than 50% of expected (down to 30%, 26%, and 24% of expected) and one received preoperative radiotherapy (26%). None of these 32 patients had symptoms of orthopnea or dyspnea at rest, and only one had dyspnea on exertion. All tolerated anesthesia without difficulty. No patient in this series suffered respiratory or cardiovascular collapse during surgery. Adequate biopsy material was obtained in all cases.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:CT quantitation of tracheal cross-sectional area as a guide to the surgical and anesthetic management of children with anterior mediastinal masses. 202 69

A 64-year-old man with non-Hodgkin's lymphoma suffered a complete collapse of the left upper lobe of the lung. Fibreoptic bronchoscopy demonstrated a large number of distinct polypoid tumours of the lymphoma in the trachea and bilateral sub-segmental bronchi. The left upper lobe bronchus was completely occluded by the tumours, which responded to the combination chemotherapy against the lymphoma. This report presents the seventh case of non-Hodgkin's lymphoma with multiple endobronchial tumours.
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PMID:Endobronchial non-Hodgkin's lymphoma. 247 64

Four patients with endobronchial non-Hodgkin's lymphoma are presented. Although endobronchial Hodgkin's disease is not uncommon, endobronchial non-Hodgkin's lymphoma is extremely rare. All patients had disseminated disease at the time of their endobronchial involvement. Chest radiographs revealed hilar masses and/or varying degrees of lobar collapse in each case. Two had multiple endobronchial lesions. Three patients died within two years of the diagnosis of endobronchial disease. The fourth patient is currently undergoing chemotherapy for disseminated disease. Lobar collapse in a patient with non-Hodgkin's lymphoma should include endobronchial involvement in the differential diagnosis. Therapy should include chest radiation in an attempt to re-expand the collapsed lung lobes and systemic chemotherapy. Prognosis is guarded due to disseminated disease at the time of diagnosis.
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PMID:Endobronchial non-Hodgkin's lymphoma. 634 1

The management of patients with critical major airways obstruction has been made possible by the recent introduction of expandable metal stents as the sole treatment or as an adjunct to other treatment modalities, to alleviate the distressing symptoms from tracheobronchial obstructions Gianturco self-expanding stents were used successfully in the management of 27 patients. The indications were: stenosis from postoperative strictures and recurrent tumours (n = 6), extrinsic compression from metastatic disease (n = 9), inoperable primary tumours of central airways (n = 9), airway collapse from relapsing polychondritis (n = 1), excessive mediastinal shift following right pneumonectomy (n = 1) and endobronchial non-Hodgkin's lymphoma (n = 1). Twenty three patients had immediate relief of stridor and the remaining two patients were successfully weaned from ventilatory support. There were two postoperative deaths. The stents were inserted under general anaesthesia through a rigid bronchoscope under direct vision. The ease of insertion under radiological control, self-expanding nature of the stents and the lack of major complications on follow-up of up to 47 months are particular advantages. The self-expanding tracheobronchial stents are a useful addition to our armamentarium in maintenance of the airways in patients with major airway stenosis and collapse.
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PMID:Self-expanding tracheobronchial stents in the management of major airway problems. 759 44

The management of patients with critical major airway obstruction has been made possible by the recent introduction of expandable metal stents as the sole treatment or as an adjunct to other treatment modalities. To alleviate the distressing symptoms from tracheobronchial obstructions Gianturco self-expanding stents were used successfully in the management of 16 patients. The indications were; stenosis from postoperative strictures and recurrent tumours (n = 6), extrinsic compression from metastatic disease (n = 4), inoperable primary tumours of central airways (n = 4), airway collapse from relapsing polychondritis (n = 1), and endobronchial non-Hodgkin's lymphoma (n = 1). Fourteen patients have immediate relief of stridor and the remaining two patients were successfully weaned from ventilatory support. The stents were inserted under general anaesthesia through a rigid bronchoscope under direct vision. The ease of insertion under radiological control, self-expanding nature of the stents and the lack of major complications on follow-up of up to 22 months are particular advantages. The self-expanding tracheobronchial stents are a useful addition to our armamentarium in maintenance of the airways in patients with major airway stenosis and collapse.
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PMID:Self-expanding tracheobronchial stents in the management of major airway problems. 793 34

A full-function vitrectomy instrument (pneumovitrector) developed by the author is described. This instrument is composed of an aspirating and cutting system combined with an infusion line for injecting air or gas into the vitreous cavity. Simultaneous injection of gas and removal of the vitreous pneumovitrectomy allows for a large vitreous biopsy specimen that has not been diluted with infusion fluid and does not reduce the intraocular pressure. A biopsy of the vitreous is performed for the diagnosis of intraocular infection and ocular involvement in reticulum cell sarcoma (non-Hodgkin's lymphoma). While aspiration of a small amount of liquid vitreous is often sufficient for the diagnosis of bacterial endophthalmitis, a larger volume of liquid and solid vitreous is needed for the establishment of diagnoses such as fungal endophthalmitis and intraocular lymphoma. Diagnostic vitrectomy is performed using either a 20-gauge needle or a 22-gauge needle or a miniaturized vitrectomy system. In the latter case, vitrectomy instruments are often combined with either an infusion cannula or an infusing fiber optic light probe. In most situations, 0.1 to 0.2 ml of vitreous is removed prior to injection and replacement of the volume of the vitreous , in order to obtain the maximum amount of undiluted vitreous for culture or histologic evaluation. Although a complete vitrectomy can be performed and the aspirate collected in the vitrectomy cassette can be spun down to obtain solid material, this procedure is generally done in the operating room. Aspiration of the vitreous for the biopsy without simultaneous replacement of the vitreous volume limits the amount of biopsy specimen that can be taken and is accompanied by the collapse of the eye as a result of hypotony. To overcome this problem, a miniaturized instrument (pneumovitrector) has been developed by this author.
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PMID:A pneumovitrector for the diagnostic biopsy of the vitreous. 883 32

Although the high incidence of EBV-associated diffuse large cell lymphomas (DLCL) in HIV-1 infection is believed to be related to loss of immune control due to HIV-induced immune deficiency, it has been claimed that cytotoxic T lymphocyte (CTL) responses to EBV are longer lasting in HIV-1-infected persons than CTL directed against HIV-1 itself. We approached this apparent paradox by performing the first longitudinal study into the kinetics of EBV and HIV-specific CTL responses in HIV-infected patients progressing either to AIDS with non-Hodgkin's lymphoma (NHL) or AIDS with opportunistic infection (OI). Multiple samples were tested from HIV-1 seroconversion to AIDS-diagnosis. Four out of six patients that were either long-term asymptomatic or progressing to OI showed declining HIV-1 CTL precursor (CTLp) frequencies whereas EBV-CTLp remained stable, suggestive for HIV-1-specific immune exhaustion. In two patients rapidly progressing to AIDS-OI, a parallel decline of HIV-1- and EBV-CTL responses was seen, indicative for total collapse of cellular immunity. In all these six patients EBV-load remained low. However, in four out of five patients that progressed to DLCL, EBV-load was high and increasing several months preceding the NHL. In all five patients, EBV-CTLp decreased before the emergence of the NHL. Thus, our data show that in HIV-1 infection loss of HIV-1-specific T cell immunity is not necessarily paralleled by loss of EBV-specific T cell responses. The occurrence of AIDS-related DLCL is preceded by decreasing EBV-CTLp and increasing EBV load. Failing EBV-control might therefore be an important step in the pathogenesis of AIDS-related DLCL.
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PMID:Epstein-Barr virus-specific cytotoxic T cell responses in HIV-1 infection: different kinetics in patients progressing to opportunistic infection or non-Hodgkin's lymphoma. 911 96

We report the imaging findings and natural history of avascular necrosis of bone (AVN) that developed following a chemotherapy regimen including high dose steroid treatment. All patients had acute lymphoblastic (ALL) or non-Hodgkin's lymphoma (NHL). Symptoms followed the high dose steroid therapy and 28 joints in eight patients were involved, (11 knees, seven hips, five shoulders and five ankles). Plain radiographs at presentation were normal in most joints, whilst bone scintigraphy and magnetic resonance imaging (MRI) were positive. We believe that the development of AVN in these patients is most likely due to the high dose dexamethasone therapy as in all eight cases symptoms followed this stage of the regimen. Patients experiencing bone or joint pains while receiving high dose steroids as part of a chemotherapy regimen could be investigated by bone scintigraphy but MRI is preferable as it is more sensitive and specific for AVN. In this series of patients multiple joints were involved and all the male patients proceeded rapidly from bone infarction to joint collapse. If the MRI appearances are typical, an early diagnosis of AVN can be made enabling therapeutic interventions to prevent joint collapse and its associated morbidity.
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PMID:Avascular necrosis of bone following an intensified chemotherapy regimen including high dose steroids. 928 21


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