Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 51-year-old man with a diagnosis of myelodysplasia and non-Hodgkin's lymphoma underwent an unmatched allogenic bone marrow transplantation and was treated posttransplant with chronic immunosuppressive medication. Eight months following transplantation, he presented with progressive dysarthria, cognitive and visual decline. Evaluation included brain magnetic resonance (MR) imaging demonstrating multifocal areas of increased T2 and FLAIR (fluid attenuated inversion recovery) signals involving the left frontal, parietal, and occipital lobes. The MR lesions demonstrated diffuse increased signal on DWI (diffusion-weighted images) and normal to low signal on ADC (apparent diffusion coefficients). Contrast-enhanced T1 images were unremarkable. Lumbar puncture revealed a mild elevation in cerebrospinal fluid (CSF) protein. CSF PCR assay for viral DNA fragments were negative on two occasions. Serum serology for HIV was negative as well. A brain biopsy was subsequently performed. The clinical and neuroimaging differential diagnoses as well as neuropathologic correlation are presented.
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PMID:A progressive neurologic disorder with multiple CNS lesions: a neuroimaging clinicopathologic correlation. Progressive multifocal leukoencephalopathy (PML). 1881 85

At present, accurate assessment of therapeutic efficacy at the early stage of treatment is still a challenge for radiologists. As a new non-radiation whole body imaging technology, Whole body-diffusion weighted imaging (WB-DWI) had shown promising application prospects in therapeutic assessment, which confirmed by many premier animal studies. Here we report that in the chemotherapeutic assessment of malignant non-Hodgkin's lymphoma, WB-DWI can not only detect the morphological change of solid infiltrated lesion as the convention (such as CT, PET, etc.) but also provide information about the growth and decline process of tumor cells in the lesion combining with the dynamic changes of apparent diffusion coefficient (ADC) value, which is sooner than the morphological changes.
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PMID:The clinical application of whole-body diffusion-weighted imaging in the early assessment of chemotherapeutic effects in lymphoma: the initial experience. 2213 88