Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An elevated serum soluble interleukin-2 receptor (SIL-2R) has been noted in various hematological malignancies and conditions associated with active T-cell responses. Its appearance has also correlated with disease activity and tumor burden. Since few studies have been reported concerning SIL-2R in cerebrospinal fluid (CSF), work was undertaken to try to find if SIL-2R could be detected in the CSF of patients with acute lymphocytic leukemia (ALL) or non-Hodgkin's lymphoma (NHL), and whether it could become a clinical predictor of the central nervous system (CNS) involvement, and its response to therapy. Preliminary results showed that 1) the CSF SIL-2R is usually detectable in very low level with a mean of 15.1 +/- 14.2 units/ml compared with the mean serum level of 338.3 +/- 135.5 units/ml in eight normal controls; 2) there was no significant difference in the mean serum and CSF SIL-2R in five patients with ALL in a complete remission state compared with normal controls, while two ALL patients with CNS relapse and two NHL patients with CNS involvement had high levels of SIL-2R in CSF. High serum and low CSF SIL-2R levels were noted in another ALL case suffering from bone marrow relapse but without CNS relapse. It was also noted that decreased CSF SIL-2R concentration occurred subsequent to intrathecal chemotherapy in two ALL patients. From these results, we conclude that CSF SIL-2R might become a useful indicator of CNS involvement in patients with hematological malignancies and may predict response to chemotherapy.
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PMID:Soluble interleukin-2 receptor levels in cerebrospinal fluid of patients with acute lymphocytic leukemia or with non-Hodgkin's lymphoma. 260 73

The serum levels of soluble interleukin 2 receptor (SIL-2R) and tumor necrosis factor (TNF) were assessed in 69 children from 6 months to 14 years old who suffered from acute lymphoblastic leukemia (39), Hodgkin's disease (15), non-Hodgkin's lymphoma (15) and in 54 normal age-matched controls prior to any therapy and at remission. Both SIL-2R and TNF levels were significantly higher at diagnosis compared with normal controls (P < 0.001), but decreased significantly at remission. The SIL-2R and TNF levels were significantly higher in an advanced stage of lymphoma than in an early stage. In the patients with acute lymphoblastic leukemia (ALL) and lymphoma, higher levels of SIL-2R (> 1030 units/ml) and TNF (> 30 pg/ml) were associated with a poorer treatment outcome (P < 0.01). Our findings indicate that elevated TNF serum secretion together with SIL-2R are useful markers in childhood ALL and lymphoma and can be used to assess both disease activity and prognosis in this group of malignancies.
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PMID:Serum levels of tumor necrosis factor and soluble interleukin 2 receptor as markers of disease activity and prognosis in childhood leukemia and lymphoma. 849 93

We studied the membrane expression of the gp80 chain of IL-6 receptor (IL-6R) by quantitative flow cytometry in chronic lymphocytic leukaemia (CLL) and leukaemic centrocytic lymphoma using a panel of seven monoclonal antibodies. IL-6R was detected in 18/26 CLL cases and 4/7 lymphoma cases, with a mean antigen density < 3000 molecules/cell. Multiple labelling experiments confirmed the IL-6R expression by neoplastic cells. Specific mRNA was found by RT-PCR in neoplastic cells. A specific ELISA test was designed using two anti-IL-6 receptor MAbs to measure the serum soluble IL-6R (sIL-6R) in CLL (n = 48). B-cell non-Hodgkin's lymphoma (NHL; n = 40), and monoclonal gammopathy (MG; n = 32). SIL-6R was higher in CLL (170 +/- 12.6 ng/ml) in NHL (160 +/- 12 ng/ml) and MG patients (183 +/- 23 ng/ml) than in age-matched controls (100 +/- 5.6 ng/ml; P < 0.001) and higher in high-grade than low-grade NHL. No correlation was noted with a previous treatment. Among CLL cases the patients classified as stage B according to the Binet's staging of the disease had the highest sIL-6R values, thus suggesting a link with tumour cell mass.
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PMID:Detection of membrane and soluble interleukin-6 receptor in lymphoid malignancies. 854 32