Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gluten-sensitive celiac disease (GSCD) belongs to systemic diseases one of manifestations of which may be various hematological disorders. Some patients with GSCD have blood changes, anemia in particular, which precede clinical symptoms of celiac disease. Anemia can arise as a result of disorders in iron, folic acid and/or vitamin B12 absorption. Celiac disease can be associated with thrombocytosis, thrombocytopenia, leucopenia, vein thrombosis, hyposplenism, immunoglobulin A deficiency. Patients with celiac disease have a high risk of lymphoma, especially of T-cell lymphoma associated with enteropathy, B-cell non-Hodgkin's lymphoma. Aglutenic diet, recovery of structure and function of the small intestine eliminate or attenuate hematological disorders associated with GSCD.
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PMID:[Hematological disorders in celiac disease]. 2189 56

We present two cases of concurrent development of essential thrombocythemia (ET) with chronic lymphocytic leukemia (CLL) and one related to clonal B-cell lymphocytosis (CBL). Both patients were referred for lymphocytosis and thrombocytosis. A bone marrow biopsy revealed infiltration of small, mature lymphocytes and megakaryocytic hyperplasia. Flow cytometric immunophenotyping and immunoglobulin (IG) gene clonality tests revealed clonal B lymphocytes. Both patients were positive for the JAK2 V617F mutation in whole bone marrow aspirate. The JAK2 V617F mutation was present in isolated B lymphocytes of patient 1, but not patient 2. Cytogenetics were normal in both patients. An array comparative genomic hybridization (CGH) analyses of B cells revealed a gain of 4q28.3, which is reported in non-Hodgkin's lymphoma, in patient 1, and deletion 22q11.22, which is associated with CLL, and a gain of Xp22.31 in patient 2. In both patients, B cells showed no myeloproliferative neoplasm (MPN)-specific genetic abnormalities. These results suggest that different oncogenic mechanisms in each cell lineage may underlie the concurrent development of ET and CLL (or CBL). Array CGH may be helpful in identifying the pathogenic mechanism in cases of concurrent development of lymphoid neoplasm and MPN.
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PMID:Two cases of concurrent development of essential thrombocythemia with chronic lymphocytic leukemia, one related to clonal B-cell lymphocytosis, tested by array comparative genomic hybridization. 2549 94


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