Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Aqueous humour drainage to the deep cervical lymphatics has been proven in animal experiments, but there have been no observations of changes in intraocular pressure (IOP) or aqueous humour drainage as a consequence of lymph drainage dysfunction. The history of a patient with non-Hodgkin's lymphoma, who underwent a left-sided radical neck dissection in January 1991, is reported. From the end of 1991 lymphoedema of the head and neck, predominantly on the right side, developed without venous stasis but with significant bilateral IOP elevation and aqueous humour outflow reduction, refract to conventional treatment. Two days after cytostatic treatment the lymphoedema disappeared, and IOP and aqueous humour outflow became normal. Four days later the patient died because of an acute bronchopneumonia. The pathological examination revealed an intact internal jugular venous system, enlarged lymph nodes and, as a consequence of previous irradiation, cicatrization in the right side of the neck. On the left side, there was absence of the internal jugular vein and jugular lymphatic trunk due to previous radical neck dissection. Our case suggests that regional lymphatic stasis and the absence of the collateral drainage to the contralateral side significantly reduces the aqueous humour outflow and leads to a bilateral, secondary IOP elevation.
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PMID:Bilateral intraocular pressure elevation and decrease of facility of aqueous humour outflow as a consequence of regional lymphoedema of head and neck. 836 47

A full-function vitrectomy instrument (pneumovitrector) developed by the author is described. This instrument is composed of an aspirating and cutting system combined with an infusion line for injecting air or gas into the vitreous cavity. Simultaneous injection of gas and removal of the vitreous pneumovitrectomy allows for a large vitreous biopsy specimen that has not been diluted with infusion fluid and does not reduce the intraocular pressure. A biopsy of the vitreous is performed for the diagnosis of intraocular infection and ocular involvement in reticulum cell sarcoma (non-Hodgkin's lymphoma). While aspiration of a small amount of liquid vitreous is often sufficient for the diagnosis of bacterial endophthalmitis, a larger volume of liquid and solid vitreous is needed for the establishment of diagnoses such as fungal endophthalmitis and intraocular lymphoma. Diagnostic vitrectomy is performed using either a 20-gauge needle or a 22-gauge needle or a miniaturized vitrectomy system. In the latter case, vitrectomy instruments are often combined with either an infusion cannula or an infusing fiber optic light probe. In most situations, 0.1 to 0.2 ml of vitreous is removed prior to injection and replacement of the volume of the vitreous , in order to obtain the maximum amount of undiluted vitreous for culture or histologic evaluation. Although a complete vitrectomy can be performed and the aspirate collected in the vitrectomy cassette can be spun down to obtain solid material, this procedure is generally done in the operating room. Aspiration of the vitreous for the biopsy without simultaneous replacement of the vitreous volume limits the amount of biopsy specimen that can be taken and is accompanied by the collapse of the eye as a result of hypotony. To overcome this problem, a miniaturized instrument (pneumovitrector) has been developed by this author.
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PMID:A pneumovitrector for the diagnostic biopsy of the vitreous. 883 32