Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary malignant lymphomas of the parapharyngeal space are rare and only 28 cases are known to have been reported. No case of malignant lymphoma arising in the temporal fossa has been previously documented. The present paper reports a case of primary non-Hodgkin's lymphoma of the parapharyngeal space in a child and two cases of lymphoma of the temporal fossa in adults. All three cases were diagnosed histopathologically from biopsy specimens as diffuse, B-cell lymphomas. For diagnosis, inspection and bimanual palpation were most important in the parapharyngeal case and the temporal cases required more than one biopsy for the final diagnosis.
Auris Nasus Larynx 1985
PMID:Malignant lymphoma in unusual areas of the head and neck: parapharyngeal space and temporal fossa. 390 7

We report an unusual case of primary extranodal non-Hodgkin's lymphoma of the parapharyngeal space. Clinical presentation looked like right peritonsillar abscess and hypoglossal palsy. After histologic study of his biopsy, this 19-year-old man was given a diagnosis of diffuse large-cell non-Hodgkin's lymphoma. Immunohistochemical study showed cell-type B and he was determined to have Stage IIE. Treatment combined chemotherapy and radiotherapy. Extranodal lymphoma of the head and neck presents a diagnostic problem. We review various approaches to extranodal non-Hodgkin's lymphomas of the head and neck. This condition especially requires communication between the surgeon and the pathologist, essential in preventing an incorrect or delayed diagnosis.
Auris Nasus Larynx 1999 Apr
PMID:Case report: extranodal non-Hodgkin's lymphoma of the parapharyngeal space. 1021 1

We report the case of a 65-year-old man with non-Hodgkin's lymphoma (NHL) not only in the brachial plexus but also in the central nervous system and parotid gland. He was referred to our hospital for evaluation of a right parotid mass. He also presented with bilateral facial palsy and paralysis of the left superior limb. Computed tomography scan and magnetic resonance imaging revealed mass lesions in the right parapharyngeal space, the deep lobe of the right parotid gland. and the left brachial plexus. A gallium-67 citrate scan demonstrated abnormal uptake in the left brachial plexus. These symptoms and lesions improved during steroid therapy. However, the symptoms worsened again after steroid therapy was discontinued. We performed a right parotidectomy to confirm the diagnosis. Histopathological study revealed NHL. He was treated with combination chemotherapy, and most of the lesions and symptoms, except bilateral facial palsy, improved. Despite follow-up treatment, a brain metastasis occured, and he died 16 months after the onset of symptoms.
Auris Nasus Larynx 1999 Jul
PMID:Primary non-Hodgkin's lymphoma of brachial plexus. 1041 43

Hypohidrotic ectodermal dysplasia (Christ-Siemens-Touraine syndrome) is characterized by partial or complete absence of sweat glands, hypotrichosis, hypodontia, prominent frontal ridges and chin, saddle nose, sunken cheeks, thick, everted lips, large ears and sparse hair. While association of other ectodermal dysplasia syndromes with tumors such a non-Hodgkin's lymphoma, hamartoma, keratoakanthoma, Merkel-cell cancer, squamous-cell carcinoma, syringofibroadenomatosis has been reported, association of hypohidrotic ectodermal dysplasia and a tumor has not been reported. In a five-year-old male patient admitted with nasal obstruction and nasal mass complaints, we have reported firstly an association of hypohidrotic ectodermal dysplasia and nasopharyngeal rhabdomyosarcoma.
Auris Nasus Larynx 2002 Jul
PMID:Nasopharyngeal rhabdomyosarcoma in a patient with hypohidrotic ectodermal dysplasia syndrome. 1216 59

It is reported that the prognosis of relapse nasal lymphoma is invariably fatal, and high-dose chemotherapy using autologous peripheral blood stem cell transplantation (auto-PBSCT) has been established as an effective treatment for patients with relapsing aggressive non-Hodgkin's lymphoma. We experienced a case with T-cell lymphoma in the nasal cavity that relapsed after the initial treatment consisting of chemotherapy and radiation therapy. We treated with high-dose chemotherapy and auto-PBSCT to the patient. The patient has been disease free without therapy for 30 months following auto-PBSCT. Our experience suggests that high-dose chemotherapy using auto-PBSCT may be one of effective treatment option for relapsed nasal T-cell lymphoma when conventional chemotherapy fails.
Auris Nasus Larynx 2004 Mar
PMID:Successful treatment of disseminated nasal T-cell lymphoma using high-dose chemotherapy and autologus peripheral blood stem cell transplantation: a case report. 1504 Oct 59

Primary malignant lymphomas in the salivary glands are relatively rare and tumors of the accessory parotid gland comprise only 1% of parotid tumors. We present two cases with a painless swelling of the cheek region. In both cases histological diagnoses of primary non-Hodgkin's lymphoma were made following complete excision of the accessory parotid gland tumor.
Auris Nasus Larynx 2004 Jun
PMID:Two cases of non-Hodgkin's lymphoma in the accessory parotid gland. 1512 Dec 32