Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Poland's syndrome is a congenital absence of the sternal portion of the pectoralis major muscle, often associated with ipsilateral upper-limb anomalies. We describe two children with non-Hodgkin's lymphoma associated with Poland's syndrome, ie, an association between childhood cancer and congenital anomalies previously unreported and unlikely to be due to chance. In addition, we report another case of acute leukemia in a child with Poland's syndrome. In view of the rarity of Poland's syndrome in the general pediatric population, we conclude that there is an increased association of the syndrome with both leukemia and non-Hodgkin's lymphoma, the biologic basis of which is unclear.
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PMID:Poland's syndrome associated with childhood non-Hodgkin's lymphoma. 658 72

This paper investigates the risk of cancer in Polish migrants to Australia, and compares the results with earlier studies, as well as with results of studies of Polish migrants in other countries. Poisson regression models were used to estimate the risk of death in Polish migrants, relative to the Australia-born, as well as the relative risk of cancer in Poland compared to the Australia-born. In migrant males, a significantly lower risk was found for oral cavity and pharynx, larynx, melanoma, prostate and Hodgkin's disease, while a significantly elevated risk was found for stomach, liver, pancreas, kidney and thyroid gland. In migrant females, a risk significantly lower than in Australian-born individuals was found for oral cavity, colon, melanoma, breast and non-Hodgkin's lymphoma. Relative risk significantly higher than in Australia-born was detected for stomach, gall bladder, pancreas, cervix uteri, nervous system and thyroid gland. For some of these cancers, the risk in migrants approximates to that of the Australia-born with increasing duration of stay. Thus, there are progressive increases in risk for colon cancer in males, and breast cancer and melanoma in females, and decreases in risk for stomach and bladder cancers in males, and uterine cancers in females.
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PMID:Cancer mortality among Polish migrants to Australia. 801 6

Data on survivals that were obtained from population-based cancer registries and representing different subpopulations in Poland, i.e., the City of Warsaw and the Warsaw Rural Areas (WRA), are presented. The overall 5-year relative survival rates calculated for males increased from 23.8% in 1963-1968 to 31.2% in 1978-1981, while no such increase was found among females (43.6 and 43.2%, respectively). The 5-year survivals were divided into three groups: (1) fairly good (40 to 100%); (2) moderate (20 to 39%); and (3) poor (below 20%). The first group also included (apart from cancer of the skin and lip, where the 5-year survival rate was 100%) cancers of the corpus uteri, Hodgkin's disease, lymphatic leukemia, malignant melanoma, testis, larynx, breast, thyroid, cervix, uteri, and prostate. The second group included cancers of the colon, bone, ovary, rectum, urinary bladder, kidney, non-Hodgkin's lymphoma, and brain. The lowest-survival group included, among other localizations, cancers of the lung, stomach, gall-bladder, pancreas, esophagus, and liver. A comparison between the 5-year survivals in Warsaw City, WRA, and the rates obtained in Finland and the U.S. showed that Polish results are considerably worse than in the other countries.
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PMID:Survival of cancer patients in Poland. 824 46

The study evaluated the incidence of infections and neoplasms in 55 out of 104 patients with AIDS who died in Poland from January 1986 to April 1994 (the estimated autopsy rate-52.8%). Histopathological examination revealed 103 infections and 11 neoplasms. In 40 persons (73%) either multiple infections or a neoplasm and an infection were diagnosed. Cytomegalovirus infection was most common. (65.5% of cases) followed by Pneumocystis carinii (24% of cases). These infections were the leading cause of death in 20% and 16% of cases, respectively. The results of this study showed a significantly lower incidence of Pneumocystis carinii, Kaposi's sarcoma and non-Hodgkin's lymphoma in comparison with the results of similar studies in countries with a large number of AIDS cases.
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PMID:AIDS pathology: infections and neoplasms in 55 fatal AIDS cases. A postmortem study. 909 7

Although the incidence of classic Kaposi's sarcoma (CKS) has been investigated, its occurrence following a primary neoplasm and its association with this first neoplasm need to be determined. We analyzed a series of 124 patients with a secondary CKS (8.4% of a total of 1485 incident cases) which occurred between 1961 and 1992 in the Jewish Israeli population. Data on first neoplasms and subsequent Kaposi's sarcoma were retrieved from the Israel Cancer Registry. Acquired-immune-deficiency-syndrome-related Kaposi's sarcomas were excluded from the case series. Four controls were randomly selected for each CKS case among all Cancer Registry cases free from a second neoplasm at the time of diagnosis of the CKS in the case, and matched on gender, year of birth and year of diagnosis of the first neoplasm. The average time lapse between first neoplasm and secondary CKS was 4.5 years, being shorter for prostate cancer and for hematopoietic malignancies. As compared with Israel-born Jews, the risk of a subsequent CKS was significantly increased in immigrants [odds ratio (OR) 3.0]; this risk was particularly high in immigrants from the former Soviet Union (OR 9.4) and Poland (OR 7.0). There was no clear trend with age at immigration; however, low age at immigration and a short length of stay in Israel endowed a higher risk of developing a secondary CKS, markedly among patients suffering from solid tumors as the first primary. There was an excess of secondary CKS following a non-Hodgkin's lymphoma (OR 5.3), a Hodgkin's lymphoma (OR 7.5), a leukemia (OR 5.3) or a breast cancer (OR 2.2). Cancer patients with a first primary in the lung, colon, stomach, larynx, liver, pancreas or kidney showed secondary CKS less frequently. Despite the lack of control of therapy for the first neoplasm, development of secondary CKS seems to be mediated by mechanisms similar to those for hematopoietic neoplasms and selected nonhematopoietic neoplasms, such as breast cancer. The trend toward increased risk after a short time lapse and the difference in risk among immigrants indicate that genetic susceptibility is part of the complex interplay between cellular proliferation and control systems.
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PMID:Classic Kaposi's sarcoma as a second primary neoplasm. 993 96

The aim of the study was to determine the side effects of asparaginase administration during treatment protocol for childhood non-Hodgkin's lymphoma (NHL). Drug adverse reactions occurred in 20/66 of patients (30,3%) treated in 9 centres in Poland between 1993 and 1998. The most common side effects were coagulation disturbances in 12/66 of the children (18,2%), which occurred due to reduced production of important coagulation factors. Six patients (9,1%) developed impairment of liver function (9,1%). Drug toxicity caused the modifications of treatment protocol in 12/66 (18,2%) of patients, mainly in the induction phase; 3 children died due to relapse of disease.
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PMID:[Adverse reactions associated with the use of L-asparaginase during therapy of patients with nB non-Hodgkin's lymphoma. Report of the Polish Paediatric LeuKaemia/Lymphoma Study Group]. 1202 64