Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Several studies have suggested that forestry workers are at increased risk for certain types of cancer including soft-tissue sarcoma (STS) and non-Hodgkin's lymphoma (NHL). We now report a series of national case-control studies based on the New Zealand Cancer Registry (NZCR). These involved 19,904 male patients with cancer for the period 1980-1984 who were aged 20 years or more at the time of registration. For each cancer site, the registrations for the remaining sites formed the control group. Current or most recent occupational titles were coded. There was an increased risk for STS (OR = 3.24) in forestry workers which was confined to men under 60 years of age at registration. An elevation in risk for NHL (OR = 1.84) was due to an increase in risk for lymphosarcoma and reticulosarcoma (ICD 200) (OR = 3.18). Acute myeloid leukemia was also associated with forestry work, although the estimate of risk was imprecise (OR = 2.24). Among other cancer sites, an increase in risk of neoplasia of the upper gastro-intestinal tract (ICD 150, 151, 152) was demonstrated. Odds ratios were elevated for cancer of the esophagus (OR = 1.77), stomach (OR = 2.22), small intestine (OR = 5.22), gall-bladder (OR = 4.13) and pancreas (OR = 1.79), as well as for nasopharyngeal cancer (OR = 5.56). These increases in cancer risk were not present in sawmill workers in New Zealand during the same period. The factors responsible for the increased cancer risks in forestry workers remain unclear and require further study.
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PMID:Soft-tissue sarcoma, non-Hodgkin's lymphoma and other cancers in New Zealand forestry workers. 291 Aug 31

This paper presents a review and further analysis of a series of New Zealand case-control studies which have found elevated risks for soft tissue sarcoma (STS), non-Hodgkin's lymphoma (NHL), and acute myeloid leukemia (AML) in abattoir workers. The first published study involved 82 cases of STS (ICD 171) and found a relative risk of 2.8 (90% confidence interval 1.3-6.3). Interviews with an additional 51 cases reported here revealed a relative risk of 1.6 (90% confidence interval 0.9-3.0). Two further studies involved interviews with 100 cases of the category of NHL involving lymphosarcoma and reticulosarcoma (ICD 200) and 83 cases of other NHL (ICD 202). Relative risk estimates were 1.8 (90% confidence interval 1.1-2.9) and 1.7 (90% confidence interval 1.0-2.8), respectively. A study of 150 cases of AML (ICD 205.0) found a relative risk of 2.5 for abattoir workers (90% confidence interval 1.3-4.7). Finally, a United States cohort study found a standardized mortality ratio of 2.4 (90% confidence interval 0.8-5.4) for Hodgkin's disease (ICD 201) and 2.2 (90% confidence interval 0.8-4.5) for cancer of other lymphatic tissue (ICD 202, 203, 208) among abattoir workers. Abattoir workers are potentially exposed to oncogenic viruses, including bovine leukemia virus. Some workers may also be exposed to the animal carcinogen 2,4,6-trichlorophenol when treating pelts.
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PMID:Increased risks of soft tissue sarcoma, malignant lymphoma, and acute myeloid leukemia in abattoir workers. 316 2

Hospitalized patients with hematological malignancy (HM) suffer an increased incidence of venous thromboembolism (VTE). We sought to identify risk factors and rate of VTE in hospitalized patients with HM using National Inpatient Sample (NIS) for the years 2011 to 2015. We used ICD-9 codes to identify patients with HM as the primary diagnosis and VTE as a secondary diagnosis for hospitalization. The rate of VTE was highest in patients with acute myeloid leukemia (6.6%) followed by acute lymphocytic leukemia (6.1%) and non-Hodgkin's lymphoma (6.0%). The highest risk of VTE occurred among patients with HM receiving chemotherapy (OR 1.68; 95% CI 1.567-1.809) followed by infection such as pneumonia (OR 1.31; 95% CI 1.201-1.436) and sepsis (OR = 1.66; 95% CI = 1.524-1.621). Chemotherapy had the highest risk of developing VTE during hospitalization followed by sepsis and pneumonia. The identification of patients with HM most at risk for VTE could be used to design and test prophylactic strategy.
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PMID:Risk factors for venous thromboembolism in hospitalized patients with hematological malignancy: an analysis of the National Inpatient Sample, 2011-2015. 3154 8