Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:Q06643 (non-Hodgkin's lymphoma)
 11,307 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A bilateral chylothorax developed in a woman patient during recurrence of a non-Hodgkin's lymphoma, originally treated by laminectomy and telecobalt irradiation. Almost simultaneously there was a thrombosis of the brachial vein in the right arm. On the basis of this particular case, attention is drawn to the difficulty in pathogenetic classification. The possible causes, especially of the bilateral nature of the chylothorax, are discussed while referring to the relevant literature.
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PMID:[Bilateral chylothorax--case report and literature review]. 176 49

Chylothorax is an accumulation of thoracic lymph or chyle in the pleural cavity. It is a rare condition and is usually caused by trauma or malignant disease. We present three cases with chylothorax due to malignant non-Hodgkin's lymphoma [high grade malignant (1 case) and low grade malignant (2 cases)] treated with pleurodesis with bleomycin and systemic chemotherapy (CHOP, CNOP, trofosfamide). Complete remissions (CR) were achieved in all three cases. Two patients had a recurrent chylothorax 3 and 12 months after initial treatment. They were treated with a second intrapleural installation of bleomycin and continuing systemic chemotherapy (CNOP, trofosfamide) and are still alive in CR with a follow-up period of 28 and 30 months respectively. One patient died of relapsing non-Hodgkin's lymphoma after 23 months of follow-up. There was no sign of recurrent chylothorax. We conclude that chylothorax caused by lymphoma can be satisfactorily controlled by pleurodesis with bleomycin combined with systemic chemotherapy. Immediate action is necessary to prevent great loss of lipids and proteins. The underlying malignancy must be controlled to achieve a good prognosis.
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PMID:Intrapleural bleomycin in the treatment of chylothorax. 753 48

We report a case of chylothorax in a 51-year-old male with non-Hodgkin's lymphoma. Combination chemotherapy reduced the size of mediastinal lymph nodes dramatically, but retroperitoneal lymph nodes remained almost the same, and chylothorax subsequently developed. Lymphangiogram showed reticular spread of contrast material from the thoracic duct downwards but not above the diaphragm. These findings suggest that an obstruction of the infra-diaphragmatic but not the supra-diaphragmatic thoracic duct caused development of collateral lymphatic channels penetrating the diaphragm into the thoracic cavity, with subsequent formation of chylothorax.
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PMID:[A case of chylothorax resulting from malignant lymphoma--pathogenesis of chylothorax: a new concept]. 846 12

Chylothorax is a rare complication of both Hodgkin's and non-Hodgkin's lymphoma (NHL). We describe a patient with a diagnosis of low grade NHL who had a persistent chylothorax unresponsive to chemotherapy, who had been diagnosed with low grade NHL. The condition rapidly resolved following mediastinal radiotherapy and did not recur despite the subsequent relapse of the NHL.
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PMID:Chylothorax in non-Hodgkin's lymphoma managed by mediastinal radiotherapy. 859 Jul 6

Intrathoracic involvement is common in both Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL). The most common manifestation is mediastinal lymphadenopathy. In HD, nodal involvement is by contiguity and usually involves the superior mediastinum, while the findings in NHL are more variable. Pulmonary parenchymal disease occurs in 38% of HD and 24% of NHL. In untreated HD, parenchymal involvement is invariably associated with mediastinal lymphadenopathy and often with widespread disease. Three distinct radiological patterns of pulmonary lymphoma are recognised: nodular, bronchovascular-lymphangitic and pneumonic-alveolar. Rarely lymphoma may be endobronchial. Pleural effusion occurs in 16% of lymphoma patients and is usually associated with disease elsewhere. It is frequently caused by lymphatic obstruction but may be due to direct pleural involvement by tumour. Chylothorax may occur in NHL but is unusual in HD. Diagnosis of intrathoracic lymphoma is by transbronchial or transthoracic biopsy or by needle aspiration of tissue or pleural fluid. The addition of immunostaining improves the diagnostic yield in equivocal cases. Treatment and prognosis vary depending on cell-type, location and extent of disease.
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PMID:Pulmonary involvement in lymphoma. 862 61

We report a case of chylothorax with malignant non-Hodgkin's lymphoma. A 51-year-old man was admitted to our hospital with a chief complaint of dyspnea on March 18, 1995. An x-ray film of the chest revealed a large right pleural effusion. Biochemical tests of the pleural fluid revealed chyle. CT scans of abdomen and chest showed retroperitoneal and mediastinal tumors. Examination of biopsy specimens of the retroperitoneal tumor showed non-Hodgkin's lymphoma (diffuse small cell type, B cell). Treatment with chemotherapy (CHOP, ProMACE-CytaBOM) resulted in complete remission. The chylothorax disappeared after chemotherapy. Only 21 cases of malignant lymphoma with chylothorax have been reported in Japan to date, but their numbers are gradually increasing. We must consider malignant lymphoma in patients with chylothorax.
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PMID:[Chylothorax resulting from malignant non Hodgkin's lymphoma]. 974 67

Chylous pleural effusion, or chylothorax, usually results from obstruction to or disruption of the thoracic duct. Malignant etiologies are the most common cause of chylothorax, lymphoma accounting for the majority of non-traumatic chylous effusions. We report an unusual case of bilateral chylothorax associated with a retrosternal toxic multinodular goiter in a patient with non-Hodgkin's lymphoma. An ablative dose of 131I was administered with apparent initial clinical improvement. The pathogenesis of chylothorax and therapeutic considerations are discussed.
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PMID:Bilateral chylothorax due to retrosternal goiter in a patient with non-Hodgkin's lymphoma. 1177 62

Systemic lymphoma that involves the aorta is called periaortic lymphoma, and may be misdiagnosed clinically or in CT sean, mimicking a thoracic aortic aneurysm, dissection, penetrating ulcer or an intramural hematoma. We report a 70 year-old woman in whom a systemic non-Hodgkin 's lymphoma ivas diagnosed after she presented with the clinical features of an acute aortic syndrome. A CT sean showed the presence of a large thoracoabdominal periaortic soft tissue mass without aneurism or dissection. Later, a biopsy of the mass ivasperformed which showed a non-Hodgkin's lymphoma. Chemotherapy with CHOP-R was effective, with complete initial resolution of the mass, developing in the follow up chylothorax, malnutrition and death.
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PMID:[Thoracoabdominal periaortic lymphoma mimicking acute aortic syndrome. Report of one case]. 1962 Nov 81