Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P80404 (
GABA transaminase
)
786
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Gabaculine, 5-amino-1,3-cyclohexadienylcarboxylate, is an analogue of GABA and a potent irreversible inhibitor of
GABA aminotransferase
. However,
D-3-aminoisobutyrate-pyruvate aminotransferase
for which GABA was neither a substrate nor an inhibitor was also inactivated by gabaculine. The Ki for
D-3-aminoisobutyrate-pyruvate aminotransferase
was 8.3 x 10(-6) M, and the Kcat for its turnover was 0.31 min-1 at 25 degrees C. beta-Alanine protected the enzyme from inactivation by gabaculine, but GABA did so to much a lesser extent.
...
PMID:Irreversible inhibition of D-3-aminoisobutyrate-pyruvate aminotransferase by gabaculine. 212 4
