Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P80404 (GABA transaminase)
 786 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Temporal and spatial developmental relationships between AChE and GABA-T reactivity in the sensory-motor cortex of rat were evaluated histochemically. Special attention was given to the barrels in layer IV of SmI that stain intensely for both enzymes. In the first and second postnatal weeks very low levels of diffuse GABA-T reactivity are seen in cortex, although cells and neuropil in the neostriatum are already clearly positive neonatally. There is little change until 16-18 days postnatal (dpn), when a steady increase in overall cortical reactivity for GABA-T has begun. In layer IV of SmI cortex, relatively intense foci of GABA-T staining begin to appear then, that overlap the barrel centers. GABA-T reactive non-pyramidal neurons at the periphery of these stained foci have distinctly stained processes that may enter the barrel centers. The intensity of GABA-T staining increases until 28 dpn when adult levels were reached. In contrast, AChE staining in cortex begins to appear at 2-3 dpn with prominent barrel staining seen by 6 dpn. When adult AChE reactivity levels are being achieved throughout all regions of neocortex, between 16-19 dpn, the barrel centers progressively lose demonstrable AChE-staining of their fiber plexus. Hence, the onset of GABA-T staining in the barrels during the third week postnatally coincides with the initiation of the progressive reduction in intensity of AChE staining in the same cortical zones. These observations on GABA-T correlate well with biochemical information on the time course of the maturation of the cortical GABAergic system.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Late postnatal changes in rat somatosensory cortex. Temporal and spatial relationships of GABA-T and AChE histochemical reactivity. 242 83

The postero-medial barrel-subfield (PMBSF) of the SI cortex of normal adult mice contains clusters of cells called "barrels". Each barrel histochemically shows increased activity of succinate, lactate, and glucose-6-phosphate dehydrogenase and also GABA-T activity. Some neuronal perikarya in the barrel walls show GABA-T activity. Mitochondrial alpha-GPDH and AChE show equal activities in the hollows and in the walls of the barrels. On this cortical vibrissa field, the contralateral and ipsilateral vibrissae project somatotopically in a way which coincides with the barrels. The mystacial vibrissae and the common fur of the muzzle project to different loci. The cortical surface area for the normal fur is 0.025 mm2, whereas the cortical vibrissal area is 1.0 mm2. In mice with lesioned whisker pads the succinate-dehydrogenase activity of the IVth layer in the vibrissal area becomes a continuous sheet similar to the adjacent IVth layer, the thickness of the cortex is relatively preserved, and the total enzyme activities, biochemically assayed, are unchanged. These features can be explained by a functional substitution. In mice with whisker pads lesioned since birth, the vibrissal area can still be identified by the projections from ipsilateral vibrissae (undamaged side). This vibrissal area, and this alone, is found to be invaded by projections from the contralateral common fur of the muzzle. Experimental data suggest that the compensatory process may result from an invasion of the vibrissal area by a new set of ascending fibers, and not merely from axonal sprouting either at the periphery or at the cortical level.
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PMID:Cortical organization of the postero-medial barrel-subfield in mice and its reorganization after destruction of vibrissal follicles after birth. 676 63