Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P80404 (GABA transaminase)
 786 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

L-Cycloserine dose-dependently inhibited the activity of gamma-aminobutyric acid (GABA)-transaminase (GABA-T) and elevated the level of GABA in whole mouse brain with a peak effect 3-4 hr after a single intraperitoneal injection. At a dose (30 mg/kg) which elevated the level of GABA almost 4-fold, L-cycloserine moderately increased the content of alanine and slightly reduced that of aspartate, glutamate and glycine in the brain. L-Cycloserine (10-30 mg/kg, p.o. or i.p.) prevented tonic seizures induced by 3-mercaptopropionic acid (3-MPA) and audiogenic seizures in DBA/2 mice, without affecting those evoked by pentylenetetrazol, bicuculline and electroshock. Similarly small doses of L-cycloserine reduced the level of cGMP in the cerebellum of rats, prevented its elevation by 3-MPA and attenuated the hypothalamically-elicited rage reaction in cats. Larger doses of L-cycloserine (greater than 30-100 mg/kg) impaired the performance of mice in the rotarod, chimney and horizontal wire tests, and reduced spontaneous locomotor activity of rats. Upon repeated administration the inhibitory effect of L-cycloserine on the activity of GABA-T and on seizures elicited by 3-MPA in mice increased. In contrast, the depressant action of L-cycloserine on motor performance and locomotion declined in subchronically-treated mice and rats. The levels of amino acids in brain after repeated administration did not differ markedly from those in acutely-treated mice. It is suggested that small doses of L-cycloserine, probably by increasing GABAergic inhibition, reduce hyperexcitability in the brain in acute- and subchronically-treated animals. Larger doses of L-cycloserine, possibly by inducing multiple neurochemical changes, evoke central depressant effects which diminish during subchronic treatment.
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PMID:L-cycloserine: behavioural and biochemical effects after single and repeated administration to mice, rats and cats. 301 1

In an attempt to characterize the effect of estrogens and progesterone on retinal GABA metabolism, female Wistar Nossan rats were ovariectomized and treated for three days with 17 beta-estradiol (1 microgram/day), estrone (2 micrograms/day), estriol (200 micrograms/day) and progesterone (500 micrograms/day) or vehicle. After 3 days of steroid hormones treatment, GAD, GABA-T activities and GABA content were measured in retina homogenate. Progesterone did not reduce GAD, GABA-T activities and GABA content from ovariectomized levels. 17 beta-estradiol, estrone and estriol decreased the GAD activity. Furthermore the decrease in GAD activity was maximal for 17 beta-estradiol whereas the estrogens treatment was ineffective on GABA-T. GABA content was significantly decreased only by 17 beta-estradiol. Estrogens reduced the Vmax of GAD for glutamate as a substrate without changing the Km.
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PMID:Effects of estrogens and progesterone on GABA system in ovariectomized rat retina. 729 12