Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P80404 (GABA transaminase)
 786 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Unanaesthetized spinal cats were used to assess the effects of several central depressant drugs on GABA-mediated presynaptic inhibition. Benzodiazepines enhance GABAergic inhibition by interaction with specific receptors in the spinal cord. Phenobarbital facilitates GABAergic inhibition by a mechanism unrelated to that of benzodiazepines, perhaps by an effect on the Cl- ionophore within the GABA-benzodiazepine-barbiturate receptor complex. A similar mechanism or the inhibition of GABA re-uptake might be responsible for the facilitating effect of valproate on GABA transmission. By selectively inhibiting GABA transaminase, L-cycloserine presumably increases the amount of GABA available for release.
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PMID:Enhancement of GABAergic inhibition: a mechanism of action of benzodiazepines, phenobarbital, valproate and L-cycloserine in the cat spinal cord. 613 Sep 36

The effect of anticonvulsant drugs was examined on brain GABA levels and GAD and GABA-T activities. The level of GABA was increased by the treatment with diphenylhydantoin. The drug had no effect on GABA-T activity, whereas GAD activity was inhibited. Carbamazepine increased the GABA level but did not effect GAD and GABA-T activities. Diazepam had no effect on GABA level and GAD activity, whereas it caused a slight inhibition of GABA-T activity. Phenobarbital administration decreased GABA level only at the higher concentration. Clonazepam effected only GAD activity. Some anticonvulsant drugs generally increase brain GABA level; however the lack of correlation with an effect on the GAD and GABA-T activities indicate that other factors than metabolism, such as membrane transport processes, are involved in the mechanism of action of anticonvulsant drugs.
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PMID:Effects of some anticonvulsant drugs on brain GABA level and GAD and GABA-T activities. 642 60