Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P80404 (GABA transaminase)
 786 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

n-di-Propylacetate (nDPA, valproate) a GABA-T inhibitor, injected IP at the dose of 300 mg/kg antagonized agonistic behavior of isolated DBA/2 mice in a time-dependent fashion in parallel to an increase of GABA levels in olfactory bulb, striatum, posterior colliculus and septum. After 75 min, aggressive responses were higher than those after 15 to 45 min and significantly lower in comparison with those of saline injected mice. After 120 min aggressive behavior was not different from that of control mice. The concentration of GABA in the striatum and olfactory bulb returned to control value 75 and 120 min after drug administration, respectively. After 120 min GABA levels in posterior colliculus and septum were lower than those after 15 to 75 min, although significantly higher in comparison with those of saline injected mice. The results are discussed in terms of the possible involvement of olfactory bulb and striatum in GABA-mediated control of isolation-induced aggressive behavior in mice.
 ...
PMID:Effects of n-di-propylacetate on aggressive behavior and brain GABA level in isolated mice. 640 34

The influence of GABA agonists and antagonists on analgesic activity of imipramine (IMA, 20 mg/kg, ip) was studied using the hotplate method. Administration of GABAA receptor agonist muscimol (1 mg/kg, ip), GABAB receptor agonist baclofen (3 mg/kg, ip) or GABA-T inhibitor aminooxyacetic acid (25 mg/kg, ip) increased the analgesic effect of IMA. On the other hand pretreatment of GABAA receptor antagonist bicucukline (2 mg/kg ip), GABAB receptor antagonist delta-amino-n-valeric acid (50 mg/kg, ip) or GABA synthesis inhibitor thiosemicarbazide (50 mg/kg, ip) attenuated the IMA analgesia. These results suggest that the analgesic action of IMA may be mediated by functional alteration of a central GABAergic mechanism and/or subsequent stimulation of GABA receptors.
 ...
PMID:GABAergic agents modify imipramine analgesia. 886 80