Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P80404 (
GABA transaminase
)
786
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Three unlinked genes where mutation can lead to D(+)-pantothenic acid auxotrophy in Aspergillus nidulans have been identified. pantoA is probably the structural gene for
pantothenate synthetase
(
EC 6.3.2.1
) whilst pantoB and pantoC are involved in the syntheses of D-pantoic acid and beta-alanine, respectively. A pantoC- mutant is tentatively considered to be blocked in conversion of 5,6-dihydrouracil to beta-ureidopropionate. An alternative route of beta-alanine biosynthesis occurs by the transamination of malonic semialdehyde, catalysed by
GABA transaminase
. The possibility that beta-alanine can be replaced by certain structurally related compounds and yet nevertheless yield biologically active coenzyme A analogues is discussed.
...
PMID:GABA transaminase provides an alternative route of beta-alanine synthesis in Aspergillus nidulans. 35 40
