Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P80404 (
GABA transaminase
)
786
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A detailed presentation of 15 case-histories of subjects of both sexes, drawn from all decennies of life from the first to the eight, suggesting a syndrome originated from a possible GABA deficiency, is carefully made. Such syndrome is believed to be characterized by basic depressive state, loss of the habit of stretching oneself, sleep disorders, mostly with early morning awakening, constipation and nuchal headache. The above symptoms have been associated to a deficiency of GABA after noting the very speed recovery after administration of
N-dipropylacetic acid
, an inhibitor of
GABA transaminase
.
...
PMID:A syndrome from a possible GABA deficiency. Clinical-therapeutic report on 15 cases. 35 28
The aims of the present studies were (a) to determine the effects of pharmacological elevation of GABA by treatment with
DPA
(competitive inhibitor of
GABA transaminase
) on a form of aggression displayed by grouped female mice towards lactating and non-lactating intruders; (b) to estimate GABA levels in six different brain areas of intact and gonadectomized male and female mice. The results revealed that
DPA
treatment considerably reduced this form of aggression. Increased GABA levels, modulated by the hormonal state of the animals, were observed in most brain areas studied.
...
PMID:Studies on the involvement of GABA in the aggression directed by groups of intact or gonadectomized male and female mice towards lactating intruders. 676 32
The effect of the
GABA transaminase
inhibitor valproic acid (
DPA
) on serotonin (5HT) metabolism of different brain regions were studied in both grouped and isolated rats. One hour after
DPA
injection 5HT levels in the amygdala were increased in grouped and isolated rats. In the hypothalamus of grouped rats, changes in 5HT metabolism were also found. The alteration in 5HT metabolism in grouped rats was reversed 150 min after injection of
DPA
. At this same time, a large and significant increase in 5HT turnover was observed in all brain areas examined in isolated rats. It can be concluded that prolonged isolation induces a differential sensitivity to the effects of
DPA
leading to differences in 5HT metabolism: the drug effect being more intense in isolated rats.
...
PMID:Effect of valproic acid on brain serotonin metabolism in isolated and grouped rats. 681 96
