Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P80404 (GABA transaminase)
 786 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Distribution of activity of phosphate-activated glutaminase, aspartate aminotransferase (AST), choline acetyltransferase (CAT) and gamma-aminobutyric acid transaminase (gamma-Abu T) in brain hippocampal formation was studied in 6 people aged 23-65 years using histochemical methods. AST marks axonic systems in neuropil layers of Ammon's horn. Glutaminase is localised in perikarya and proximal segments of pyramidal and granular neurons dendrites. CAT is identified in terminal-like dotted structures in pyramidal and granular layers and also in certain nonpyramidal cells of stratum lacunosum molecular of field CAI. Product of histochemical reaction to gamma-Abu-T stains pericellular plexuses in basis layers of Ammon's horn and denticulate fascia. A generalizing scheme of neurochemical organization of hippocampal formation links is represented in the study.
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PMID:[The neurochemical characteristics of the neurons in the human hippocampal formation]. 916 12

100 mg of taurine per kg body weight had been administered intraperitoneally and 30 min after the administration the animals were sacrificed. Glutamate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, glutaminase, glutamine synthetase, glutamate decarboxylase and GABA aminotransferase along with the content of glutamate and GABA in cerebral cortex, cerebellum and brain stem were studied and compared with the same obtained in the rats treated with normal saline in place of taurine. The results indicated a significant decrease in the activity of glutamate dehydrogenase in cerebral cortex and cerebellum and a significant increase in brain stem. Glutaminase and glutamine synthetase were found to increase significantly both in cerebral cortex and cerebellum. The activities of glutamate decarboxylase was found to increase in all the three regions along with a significant decrease in GABA aminotransferase while the content of glutamate showed a decrease in all the three brain regions, the content of GABA was observed to increase significantly. The above effects of taurine on the metabolism of glutamate and GABA are discussed in relation to the functional role of GABA and glutamate. The results indicate that taurine administration would result in a state of inhibition in brain.
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PMID:Acute metabolic effects of taurine on the enzymes metabolizing glutamate and gaba. 2049 55