Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P80404 (
GABA transaminase
)
786
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Two patients with
Nelson's syndrome
and one patient after bilateral adrenalectomy for Cushing's disease, without any evidence of
Nelson's syndrome
, were studied with respect to the effect of hydrocortisone, naloxone and valproic acid (a
GABA transaminase
inhibitor) on ACTH secretion. Hydrocortisone suppressed plasma ACTH concentrations to normal in the patient without
Nelson's syndrome
, but failed to do so in the two patients with
Nelson's syndrome
. Naloxone and valproic acid caused a decline in plasma ACTH concentrations in the patients with
Nelson's syndrome
, but produced no change in the patient without
Nelson's syndrome
. Secretion of ACTH may thus be influenced by both opiate peptide and by gamma aminobutyric acid, as well as by the cortisol concentration, these agents may act at different sites to inhibit ACTH release by the tumour.
...
PMID:Effects of valproic acid, naloxone and hydrocortisone in Nelson's syndrome and cushing's disease. 627 25
