Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P62988 (Ubiquitin)
 4,326 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Ubiquitin 4326
ubiquitin 2625
proteasome 1087
Mol 672
Sep 246
ubiquitin ligase 243
E3 ubiquitin ligase 190
ATP 158
deubiquitinating enzyme 141
Proteasome 134
NMR 134
SUMO 125
p53 121
endoplasmic reticulum 103
fused 94
SCF 88
polypeptide 85
proteasome inhibitor 84
ubiquitin-conjugating enzyme 82
interferon 76
p62 76
peptidase 75
ATPase 72
diubiquitin 66
Ubc13 63
cytokine 59
ubiquitin-specific protease 59
NEMO 57
cullin 56
A20 52
BRCA1 51
histone 50
TNF 50
TRAF6 46
IKK 45
ubiquitin-like protein 44
CYLD 44
Skp1 43
F-box protein 42
interacting protein 42
LC3 41
NEDD8 41
PDB 41
p97 41
RIG-I 40
proliferating cell nuclear antigen 39
PHD 38
Parkin 37
zinc finger 35
E2 ubiquitin-conjugating enzyme 35
APC 33
tumor necrosis factor 33
Rpn10 33
GST 32
ISG15 31
cyclin 31
USP7 30
IFN 30
p21 28
TAK1 28
histone H2A 28
insulin 27
catenin 27
Cdc48 26
amyloid precursor protein 26
SDS 26
AAA 25
adaptor protein 25
caspase-3 25
axonal 25
ubiquitin conjugating enzyme 25
USP5 25
VCP 25
JNK 24
Mdm2 24
UBC 24
type I interferon 23
K27 23
ataxin-3 23
IkappaB kinase 22
dimeric 21
alpha-synuclein 21
cysteine protease 21
SUMO2 21
Bcl-2 21
threonine 21
RNF8 21
Dsk2 21
lipopolysaccharide 21
p38 21
SUMO-1 21
lysozyme 20
LPS 20
SUMO1 20
ribosomal protein 19
membrane protein 19
UBC13 19
E6AP 19
PINK1 19
TDP-43 19
nuclear protein 19
RNF168 18
USP14 18
synuclein 18
MAVS 18
53BP1 18
TNF receptor 17
p65 17
CUL1 17
E6-AP 17
SUMO-2 17
histone H3 17
HSP70 17
AKT 17
c-Myc 17
muscle protein 17
phosphatase 16
CXCR4 16
MAPK 16
ERK 16
UBC4 16
TRAF2 16
p27 16
CA1 16
H2A 16
ROS 16
AMP 16
AMSH 16
IL-1 16
IkappaBalpha 16
ubiquitin-protein ligase 16
tau protein 16
tumour suppressor 16
PI3K 16
COP9 16
TAB2 16
housekeeping 16
CHIP 16
anaphase-promoting complex/cyclosome 15
MDM2 15
UHRF1 15
heat shock protein 15
mTOR 15
chymotrypsin-like 15
caspase-8 15
ubiquitin fusion protein 15
UTR 15
X-linked 15
huntingtin 15
cIAP2 15
BARD1 14
UCH-L1 14
parkin 14
RNF4 14
ADP 14
XIAP 14
calpain 14
SHARPIN 14
Itch 14
RIP1 14
more...
Disease
cancer 432
tumor 278
Alzheimer's disease 109
tumorigenesis 105
Parkinson's disease 80
virus infection 64
dementia 61
amyotrophic lateral sclerosis 54
breast cancer 52
tumor progression 46
hepatocellular carcinoma 42
tumor growth 37
CYLD 35
APC 34
leukemia 33
ischemia 29
carcinoma 28
cold 27
motor neuron disease 27
SDS 26
carcinogenesis 26
multiple myeloma 25
abdominal aortic aneurysm 25
muscular atrophy 25
AAA 25
colorectal cancer 24
lung cancer 24
diabetes 24
adenocarcinoma 22
prostate cancer 21
gastric cancer 18
Huntington's disease 18
immunodeficiency 18
metastases 16
ovarian cancer 16
myopathy 16
non-small cell lung cancer 16
influenza 15
sepsis 15
HIV 15
tuberculosis 14
pruritus 14
parkinsonism 14
SARS 14
heart failure 13
Epstein 13
Legionella 13
infertility 13
squamous cell carcinoma 13
melanoma 13
sepsis 13
liver disease 12
glioma 12
herpes simplex 12
ATM 12
depression 12
PDB 12
Pick's disease 12
Mycobacterium 12
Dementia with Lewy bodies 11
plaque 11
hypertension 11
acute promyelocytic leukemia 11
PML 11
MCF 10
pancreatic cancer 10
progressive supranuclear palsy 10
colon cancer 10
anemia 10
neuroblastoma 9
lymphoma 9
Angelman syndrome 9
Kaposi's sarcoma 9
bacterial infection 9
hepatitis B 9
Hippel 8
male infertility 8
glioblastoma 8
autoimmune disease 8
liver cancer 8
cytomegalovirus 8
B-cell lymphoma 8
heart disease 7
cirrhosis 7
cervical cancer 7
rheumatoid arthritis 7
wasting 7
hepatitis C 7
stroke 7
liver cancer 7
cystic fibrosis 7
B-cell lymphomas 7
obesity 7
worms 7
GSH 6
Fanconi 6
cerebral ischemia 6
osteosarcoma 6
infectious diseases 6
atherosclerosis 6
cognitive impairment 6
epithelial ovarian cancer 6
dermatitis 6
acute myeloid leukemia 6
epididymis 6
Machado-Joseph disease 6
FTLD 6
aphasia 6
endometrial cancer 6
abortion 6
Creutzfeldt-Jakob disease 5
muscular dystrophy 5
multiple sclerosis 5
aggressiveness 5
multiple disorders 5
retinoblastoma 5
ectodermal dysplasia 5
PARK2 5
epilepsy 5
ARF 5
renal cell carcinoma 5
malnutrition 5
schizophrenia 5
brain tumor 5
hematologic malignancies 5
hepatitis 5
myocardial ischemia 5
Recruitment 5
LBD 5
congestive heart failure 4
Yersinia 4
Hepatocellular carcinoma 4
arthritis 4
Down syndrome 4
Rosenthal 4
stomatitis 4
cardiomyopathy 4
inflammatory bowel disease 4
type 2 diabetes 4
fatty liver 4
Crohn's disease 4
asthma 4
glaucoma 4
astrocytoma 4
erythroleukemia 4
genetic disorder 4
pneumonia 4
colitis 4
acute lymphoblastic leukemia 4
malaria 4
VISA 4
myocardial infarction 4
systemic lupus erythematosus 4
mimicry 4
NS3 4
lung disease 4
myelodysplastic syndrome 4
mammary tumor 3
mucosa-associated lymphoid tissue 3
sarcoma 3
more...
Symptom
starvation 31
ataxia 16
weakness 9
collapse 7
seizures 6
respiratory distress 5
cachexia 5
diarrhea 4
tremor 4
pain 4
myoclonus 2
dysarthria 2
hypothermia 2
bradykinesia 2
fatigue 2
hypotonia 2
pallor 1
irregular bleeding 1
erythema 1
cerebellar ataxia 1
apathy 1
despair 1
twitching 1
hepatomegaly 1
sleepiness 1
anorexia 1
anesthesia 1
dystonia 1
Flaccid dysarthria 1
splenomegaly 1
loss of taste 1
acute stress 1
exhaustion 1
spasticity 1
memory loss 1
male subfertility 1
agitation 1
colic 1
acidity 1
Drug
lysine 427
Parkin 37
Parkin 37
ROS 16
AMC 12
Bortezomib 10
Retinoic acid 6
GEO 4
Asn 4
Monit 4
Biopolymers 4
Adriamycin 3
IFN-gamma 3
Gel 3
CSF 3
Glutathione 3
TAT 3
Cardiovasc 3
Kenyan 3
ACT 3
NADH 3
ROC 3
Fraction 3
EE2 2
IFN-beta 2
L-tyrosine 2
MAP 2
Ethanol 2
IL-2 2
Leaf 2
Amiloride 2
Amiloride 2
ascorbate 2
RFP 2
Gleevec 1
CTC 1
Paraffin 1
Forskolin 1
ATV 1
Glycerol 1
MDM 1
citric acid 1
caffeine 1
Maltose 1
ADR 1
p75 1
BLM 1
ABC 1
HCG 1
Lenalidomide 1
Singular 1
Heme 1
DM1 1
Glide 1
TAK 1
Ketoconazole 1
Nitric Oxide 1
Gefitinib 1
Fluconazole 1
RBT 1
CTC 1
Itraconazole 1
BH4 1
Capsicum 1
Dihydro 1
Alliance 1
Gelatin 1
TAC 1
Dermatol 1
PCP 1
balanced salt solution 1
Angiotensin II 1
NVP 1
Asthma 1
ADM 1
Xanthium 1
Fluorescein 1
Papain 1
Enzyme
proteasome 1094
IKK 82
protein kinase 80
ATPase 74
mitogen-activated protein kinase 66
ubiquitin-protein ligase 55
isopeptidase 51
PHD 38
glutathione S-transferase 38
ERK 37
APC 35
trypsin 32
luciferase 26
papain 24
caspase-3 22
glyceraldehyde-3-phosphate dehydrogenase 20
lysozyme 20
protein kinase C 18
calcineurin 16
glyceraldehyde-3-phosphate dehydrogenase 15
AMP-activated protein kinase 14
ACS 13
beta-glucuronidase 12
superoxide dismutase 12
caspase-8 12
cdc2 12
glyceraldehyde-3-phosphate dehydrogenase 11
AMPK 11
glyceraldehyde-3-phosphate dehydrogenase 11
glyceraldehyde-3-phosphate dehydrogenase 11
RNA polymerase 11
PARP 11
AMPK 10
protein phosphatase 2A 10
cathepsin B 10
ornithine decarboxylase 9
catalase 9
focal adhesion kinase 8
peroxidase 8
MEK 8
beta-galactosidase 8
RNase 7
cathepsin D 7
tyrosine hydroxylase 7
MEKK1 6
phosphatidylinositol 3-kinase 6
polo-like kinase 1 6
dihydrofolate reductase 5
GSK 5
chymotrypsin 5
carbonic anhydrase 5
topoisomerase 4
caspase-1 4
DNA polymerase 4
lipoxygenase 4
conjugase 4
RNase 4
carboxypeptidase Y 4
ubiquityl-calmodulin synthetase 4
endonuclease 4
phosphoglycerate kinase 4
3C protease 3
reverse transcriptase 3
Protein 2 3
caspase-9 3
chloramphenicol acetyltransferase 3
demethylase 3
phosphoinositide 3-kinase 3
CEP 3
TAT 3
aspartate aminotransferase 3
alkaline phosphatase 3
phosphodiesterase 3
CEP 3
peroxiredoxin 3
phospholipase C 3
NADPH oxidase 3
complex I 3
topoisomerase 3
histone acetyltransferase 3
invertase 3
NADPH oxidase 3
TPP 3
transcriptase 2
laccase 2
glutathione peroxidase 2
calpain 3 2
glutamine synthetase 2
phytoene synthase 2
phosphorylase kinase 2
TPP 2
DNA methyltransferase 2
lysyl endopeptidase 2
PGM 2
choline kinase 2
firefly luciferase 2
phosphorylase 2
phospholipase A2 2
transglutaminase 2
MMP 2
CD10 2
furin 2
p100 2
granzyme B 2
ribonucleotide reductase 2
histone demethylase 2
thymidylate synthase 2
creatine kinase 2
heme oxygenase 2
MAT 2
ribonucleotide reductase 2
chalcone synthase 2
starch synthase 2
trehalase 2
TOR 2
cytidine deaminase 2
TSA 2
acid phosphatase 2
adenylate cyclase 2
rhodanese 2
neuraminidase 2
collagenase 2
ECH 2
NO synthase 2
MAT 2
3-hydroxyacyl-CoA dehydrogenase 1
cathepsin S 1
adenine phosphoribosyltransferase 1
tyrosinase 1
bleomycin hydrolase 1
triphosphatase 1
prenyltransferase 1
PKG 1
prenyltransferase 1
glucokinase 1
aconitase 1
m-calpain 1
farnesyltransferase 1
aspartyl-tRNA synthetase 1
GRK2 1
SCP 1
CaMKII 1
aldehyde dehydrogenase 1
p-nitrophenylphosphatase 1
chitinase 1
oxidosqualene cyclase 1
carboxypeptidase 1 1
ACC synthase 1
Lys4 1
prenyltransferase 1
10-formyltetrahydrofolate dehydrogenase 1
PCP 1
aldehyde dehydrogenase 1
pectinase 1
cysteine synthase 1
arginine decarboxylase 1
chitin synthase 1
ribonuclease 1
deaminase 1
NMT 1
more...
Compound
Ubiquitin 2654
lysine 593
DNA 552
Dec 309
ATP 158
cysteine 104
tyrosine 53
TNF 50
oxygen 50
zinc 48
serine 46
arginine 46
Clin 43
Gly 42
alanine 42
methionine 41
His 40
water 40
leucine 37
salt 36
threonine 36
hydrogen 34
calcium 31
Phe 26
glucose 26
SDS 26
AAA 25
sodium 25
Cbl 23
CUE 22
aldehyde 20
aldehyde 20
Ile 19
phosphate 19
Asp 19
NH2 17
sulfate 17
glutamine 16
AMP 16
cAMP 16
glutamate 16
ADP 15
Cardiol 15
CHIP 15
cadmium 15
acetate 15
iron 14
ADP 14
ADP 14
ACS 13
proline 13
urea 13
ACS 13
retinoic acid 12
TOF 12
ethanol 12
PEG 12
MDA 12
nitric oxide 11
nitrogen 11
tryptophan 11
MTT 11
GSH 9
Neuronal 9
salicylic acid 9
GSH 9
PDB 9
potassium 9
H2O2 8
DPA 8
tryptophan 8
methanol 8
boron 7
copper 7
TNM 7
cGMP 7
ABA 7
PEG 7
silver 7
ABA 7
bromide 6
pyrimidine 6
isoleucine 6
tryptophan 6
RUB 6
ammonium 6
DEAE 6
tryptophan 6
Histone 6
isoleucine 6
galactose 6
asparagine 6
Triton X-100 6
Vimentin 5
GlcNAc 5
nickel 5
methyl methanesulfonate 5
GTP 5
THP 5
Pac 5
vinyl 5
40S 5
Phytol 4
PPi 4
Phytol 4
CAT 4
THP 4
TAR 4
Rapamycin 4
Cysteine 4
CO2 4
guanidine 4
CAT 4
NAD 4
Cycloheximide 4
NTA 4
CAT 4
Insulin 4
DDP 4
NAD 4
pyrimidine 4
AMPA 4
ADP-ribose 3
hydroxylamine 3
TEM 3
Carbon 3
Cereb 3
hydroxylamine 3
IAA 3
IAA 3
silicon 3
EDTA 3
acetic acid 3
valine 3
NADH 3
manganese 3
AFC 3
GSSG 3
COS 3
CAP 3
prostaglandin J2 3
Sucrose 3
CAP 3
Adriamycin 3
CAM 3
Estrogen 3
formaldehyde 3
Histidine 3
Optimal 3
MEK 3
BMC 3
NMDA 3
C2H2 3
N-acetylcysteine 3
GABA 3
TCA 3
EDTA 3
GABA 3
TDP 3
aspartic acid 3
more...