Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P62988 (
Ubiquitin
)
4,326
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Members of the super-class of zinc finger proteins are key regulators in early embryogenesis. Utilizing in silico mining of EST Databases for pre-implantation Embryo-Specific Zinc Finger Protein Genes, we characterized a novel zygotic mouse gene-
tripartite motif family-like 1
(
TRIML1
), which expresses in embryo before implantation. Knocking down of
TRIML1
resulted in the fewer cell number of blastocysts and failture to give rise to neonates after embryo transfer. The binding partner of
TRIML1
,
Ubiquitin
-specific protease 5 (USP5), was identified by yeast two-hybrid screening assay. The interaction was confirmed by GST pull-down and coimmunoprecipitation analysis. The role of
TRIML1
in ubiquitin pathway during the development stage of mouse blastocyst was further discussed.
...
PMID:Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1. 1915 9
