Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P61278 (somatostatin)
 22,083 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
somatostatin 22083
insulin 4199
glucagon 3261
growth hormone 2087
SRIF 1933
gastrin 1776
substance P 1745
Sep 1438
somatostatin receptor 1155
cholecystokinin 1131
neuropeptide Y 1069
polypeptide 1034
pancreatic polypeptide 979
calcitonin 950
Mol 811
neurotensin 768
vasoactive intestinal peptide 710
parvalbumin 708
GHRH 705
beta-endorphin 644
gut 639
SMS 603
bombesin 591
secretin 549
prolactin 506
GABA 470
galanin 464
vasoactive intestinal peptide (VIP) 460
vasopressin 439
ACTH 419
adenylate cyclase 412
SSTR2 323
AMP 321
motilin 320
tyrosine hydroxylase 319
VIP 311
ghrelin 308
TRH 304
IGF-I 299
CCK 295
chromogranin A 281
calretinin 278
Growth hormone 268
calbindin 267
CA1 266
oxytocin 258
SSTR5 240
nitric oxide synthase 238
thyrotropin-releasing hormone 237
peroxidase 237
SSTR1 232
dynorphin 232
amylase 210
Gen 209
choline acetyltransferase 203
adenylyl cyclase 203
LHRH 196
neuron-specific enolase 191
PRL 187
corticotropin-releasing factor 184
gastrin-releasing peptide 182
axonal 179
insulin-like growth factor 172
5-hydroxytryptamine 170
GTP 163
synaptophysin 161
epidermal growth factor 160
BOD 155
peptide YY 154
mTOR 153
IGF-1 150
MRI 150
ATP 146
NPY 142
insulin-like growth factor I 141
interferon 140
Neuropeptide Y 137
cortistatin 136
SSTR3 135
SST 134
olfactory 133
gastric inhibitory polypeptide 132
CA3 132
SOM 128
glutamic acid decarboxylase 128
insulin-like growth factor-I 125
acetylcholinesterase 122
angiotensin II 116
GHRP 115
bradykinin 115
FDG 113
GH receptor 110
LAR 106
adrenocorticotropic hormone 105
SSTR4 105
cytokine 95
leptin 94
tyrosine kinase 92
thyroid hormone 91
Met 88
progranulin 88
She 88
Met-enkephalin 88
collagenase 85
Calcitonin 84
CSF 84
FSH 84
endoplasmic reticulum 82
amylin 82
CGRP 81
vascular endothelial growth factor 81
Ghrelin 80
CRH 79
neuronal nitric oxide synthase 79
thymus 77
NMR 76
c-fos 75
arginine vasopressin 74
Ki-67 74
phosphodiesterase 73
nerve growth factor 73
pituitary adenylate cyclase-activating polypeptide 72
CRF 71
opioid receptor 70
carcinoembryonic antigen 69
GIP 69
growth hormone releasing hormone 69
lipase 69
Leu-enkephalin 69
G protein-coupled receptor 69
GLP-1 67
albumin 67
Pol 67
collagen 65
lymphoid 65
thyroglobulin 64
proton pump 63
CREB 62
ADP 61
proinsulin 61
Vasoactive intestinal peptide 61
NET 60
glial fibrillary acidic protein 59
ATPase 59
insulin-like growth factor 1 58
glycoprotein 58
GAD67 58
PAP 58
renin 57
lipopolysaccharide 57
rat) 56
NMDA receptor 55
fused 55
muscarinic receptor 54
Net 54
G-protein-coupled receptor 54
somatostatin receptor 2 53
calcium channel 53
tumor necrosis factor 52
membrane-bound 52
more...
Disease
tumor 2442
diabetes 1236
cancer 1112
acromegaly 771
metastases 674
carcinoid 629
SMS 603
hypoglycemia 470
hyperglycemia 442
pertussis 395
Alzheimer's disease 354
carcinoma 350
neuroendocrine tumor 303
carcinoid syndrome 260
tumor growth 260
adenoma 256
hyperinsulinemia 250
depression 219
Pituitary 218
SEM 216
insulinoma 211
obesity 205
liver metastases 205
pituitary adenoma 205
pituitary tumor 188
medullary thyroid carcinoma 175
varices 168
adenocarcinoma 162
multiple endocrine neoplasia 156
type 2 diabetes 153
breast cancer 152
cirrhosis 145
epilepsy 144
acute pancreatitis 139
pancreatitis 137
hypertension 137
Pancreas 130
Pancreas 129
gallstones 122
gastrinoma 119
prostate cancer 117
Zollinger-Ellison syndrome 115
dementia 114
portal hypertension 112
schizophrenia 109
Cushing's syndrome 109
primary tumor 108
pancreatic cancer 107
Cushing's disease 107
glucose intolerance 107
pheochromocytoma 107
somatostatinoma 106
chronic renal failure 103
neuroblastoma 102
glucagonoma 101
Huntington's disease 97
type 1 diabetes 96
ischemia 92
duodenal ulcer 92
cold 90
Parkinson's disease 90
hyperthyroidism 85
peptic ulcer 83
esophageal varices 80
cholera 75
lung cancer 73
paraganglioma 72
lymphoma 70
neuroendocrine carcinoma 70
chronic pancreatitis 68
hypothyroidism 65
hepatocellular carcinoma 65
celiac disease 64
temporal lobe epilepsy 62
small cell lung cancer 62
gastritis 60
tumor progression 59
plaque 58
chylothorax 57
tumorigenesis 55
meningioma 54
lung carcinoma 53
carcinogenesis 53
hypopituitarism 51
Best 50
status epilepticus 50
leukemia 48
prolactinoma 47
atrophic gastritis 47
sepsis 47
diabetic retinopathy 46
disinhibition 46
liver disease 45
major depressive disorder 44
heart disease 44
TOC 44
sepsis 44
steatorrhea 44
thyroid cancer 43
hypercortisolism 42
MEN1 42
residual disease 41
hyperprolactinemia 40
neurofibromatosis type 1 40
glioma 40
renal failure 40
rare disease 40
MCF 40
melanoma 39
cognitive impairment 38
hypercalcemia 38
anemia 38
AIDS 38
VIPoma 37
heart failure 37
dumping syndrome 37
bone metastases 37
gastric cancer 37
bowel obstruction 36
Graves' disease 36
gastric ulcer 35
dysplasia 34
Hodgkin's disease 34
colorectal cancer 34
colon cancer 34
SDS 33
Graves' ophthalmopathy 32
irritable bowel syndrome 32
aggressiveness 32
hyperphagia 31
psoriasis 31
fits 31
HIV 31
autism 31
Giant 30
dyspepsia 30
Crohn's disease 29
aggression 29
rheumatoid arthritis 28
Evans 28
malnutrition 27
Helicobacter pylori infection 27
Hippel 27
retinopathy 26
non-small cell lung cancer 26
renal disease 26
neurofibromatosis 26
chronic pain 26
pruritus 25
stroke 25
arthritis 24
hyperparathyroidism 24
GAD 24
AA1 24
inflammatory bowel disease 24
Somatostatinomas 24
uterus 24
malabsorption 23
GSH 23
polycystic kidney 23
more...
Symptom
diarrhea 421
pain 314
seizures 264
anesthesia 110
flushing 103
abdominal pain 93
headache 81
analgesia 54
nausea 52
vomiting 51
constipation 43
starvation 40
acidity 39
erythema 36
fatigue 36
anorexia 33
nausea and vomiting 20
hypothermia 19
epigastric pain 18
discomfort 16
weakness 16
discomfort 16
acute stress 15
hunger 14
bone pain 13
dyspnea 13
abdominal cramps 12
respiratory distress 12
abdominal discomfort 12
arthralgia 11
tremor 11
overweight 11
cachexia 10
wheezing 10
exhaustion 9
ataxia 8
functional recovery 8
polyuria 8
polydipsia 8
HSA 7
bloating 7
dystonia 7
excessive sweating 7
memory loss 7
dizziness 7
sleepiness 6
Ill 6
paresthesia 6
ketonuria 6
agitation 6
acute pain 6
POA 6
collapse 6
cancer pain 6
autodigestion 5
chest pain 5
low back pain 5
lethargy 5
syncope 5
hepatomegaly 5
hypercapnia 5
neuralgia 4
Wind 4
shortness of breath 4
cough 4
angina 4
back pain 4
hypoproteinemia 4
myoclonus 4
regurgitation 3
emaciation 3
exertional dyspnea 3
Welt 3
chorea 3
chronic constipation 3
hemoptysis 3
Cushingoid 3
cyanosis 3
intestinal bleeding 3
Deafferentation 3
tinnitus 3
ophthalmoplegia 2
insomnia 2
hyperoxia 2
generalized rash 2
right upper quadrant pain 2
orofacial pain 2
myalgia 2
Neuropathic pain 2
fever of unknown origin 2
catatonia 2
rigors 2
spasm 2
blurred vision 2
splenomegaly 2
nasal congestion 2
Gastrointestinal symptoms 2
thinning 2
Cushingoid 2
paresis 2
anosmia 2
bitter taste 2
colic 2
leg edema 2
chyluria 2
abdominal fullness 1
tachypnea 1
rundown 1
tonic seizure 1
facial pain 1
fasciculation 1
Lid lag 1
phosphatemia 1
stomach distension 1
acute abdominal pain 1
prostatism 1
Severe diarrhea 1
athetosis 1
stomach cramps 1
periorbital edema 1
heartburn 1
prostration 1
hemiplegia 1
Gurgling 1
impaired motor coordination 1
hepatosplenomegaly 1
hip pain 1
hoarseness 1
acute abdomen 1
blushing 1
Neurologic symptoms 1
eds 1
labored breathing 1
sneezing 1
ENT 1
flank pain 1
Paroxysmal hypertension 1
paraparesis 1
spasticity 1
pleuritic chest pain 1
night sweats 1
general problem 1
apathy 1
photophobia 1
physical appearance 1
Motor dysfunction 1
masculinization 1
No adverse effect 1
tense 1
numbness 1
neurological disability 1
nasal discharge 1
stridor 1
clubbing 1
tenesmus 1
Food intolerance 1
musculoskeletal impairment 1
Excitability 1
Sharp pain 1
Regurgitation 1
more...
Drug
Glucagon 297
Growth hormone 253
Growth hormone 211
Sandostatin 205
Sandostatin 205
GRF 173
Gel 95
lysine 92
CSF 90
GHRP 78
Secretin 75
Atropine 69
Forskolin 63
ENT 61
Nephron 56
Asn 52
Sandostatin LAR 46
Pegvisomant 42
Histamine 42
Dermatol 38
Portal 36
OctreoScan 36
nitroglycerin 31
Cardiovasc 30
Omeprazole 24
Paraffin 23
PTH 23
IFN-gamma 21
Everolimus 21
IL-2 19
Indomethacin 19
Leaf 18
Luteinizing 17
caffeine 17
Phentolamine 16
ICI 16
EE2 16
DNase I 15
Biopolymers 14
Terlipressin 13
Terlipressin 13
Clonidine 13
Ethanol 12
DMSA 12
ABC 12
Theophylline 11
Vapreotide 11
MAP 11
DHT 10
Cimetidine 10
Gastro 10
DHT 10
Cimetidine 10
Alanine 10
Fructose 9
Albumin 9
Activin 9
CaCl2 9
Angiotensin II 9
CaCl2 9
CaCl2 9
HCG 8
Cetrorelix 8
CAM 7
ADM 7
Kainic acid 7
ascorbate 7
HCH 7
ETA 7
Ringer's solution 6
Bisacodyl 6
CTX 6
Proglumide 6
NADH 6
Retinoic acid 6
Ranitidine 6
Apomorphine 6
PCB 6
Ketoconazole 6
Thyroglobulin 5
CPT-11 5
lactose 5
CoCl2 5
Fraction 5
CoCl2 5
Monit 5
Diurnal 5
MTC 5
Dial 5
Parlodel 5
Loxiglumide 4
Parlodel 4
Vitamin E 4
Reserpine 4
p75 4
Prednisone 4
Spectrum 4
ISP 4
Fluorescein 4
Enprostil 4
PCP 4
vitamin E 4
Ouabain 4
balanced salt solution 4
Nephron 4
Lipiodol 4
Scopolamine 4
Trifluoperazine 4
ROC 4
G-CSF 4
Frontal 4
CPR 3
Aminoguanidine 3
Humulin 3
Dextrose 3
NaI 3
ZnCl2 3
Salbutamol 3
NaI 3
Orphan 3
Phenytoin 3
Glutathione 3
MEA 3
PPA 3
NaI 3
Bevacizumab 3
Fluorescein 3
NaI 3
ZnCl2 3
DM1 3
Pitressin 3
Estrogens 3
Aprotinin 3
Depreotide 3
Zoladex 3
Sulpiride 3
Pilocarpine 3
NH3 3
Zoladex 3
ROS 3
DEX 3
Gliclazide 3
EPI 2
Fentanyl 2
EHDP 2
Intron A 2
ALA 2
Phosphoramidon 2
Etoposide 2
Hypaque 2
Zinc sulfate 2
K-252a 2
Sucralfate 2
Imatinib 2
Galactose 2
TRM 2
Liposyn 2
PTC 2
Pronase 2
DMI 2
more...
Enzyme
adenylate cyclase 426
tyrosine hydroxylase 312
peroxidase 262
protein kinase 235
choline acetyltransferase 204
protein kinase C 185
ERK 143
acetylcholinesterase 142
SST 134
mitogen-activated protein kinase 131
NADPH-diaphorase 104
trypsin 87
collagenase 85
pepsin 76
NO synthase 75
lipase 74
phosphodiesterase 73
phospholipase C 69
ATPase 69
renin 57
reverse transcriptase 55
CD10 50
enolase 47
glutamate decarboxylase 47
alkaline phosphatase 46
histidine decarboxylase 43
diaphorase 41
dopamine beta-hydroxylase 41
diaphorase 40
NQO1 40
catalase 34
luciferase 32
cholinesterase 31
guanylate cyclase 31
glucokinase 30
calcineurin 30
chymotrypsin 30
superoxide dismutase 29
NOS 28
acid phosphatase 28
caspase-3 25
AMPK 24
focal adhesion kinase 23
chloramphenicol acetyltransferase 22
MEK 22
RNase 22
phospholipase A2 21
PTPase 21
RNase 21
lipoxygenase 20
lactate dehydrogenase 19
transcriptase 19
ACE 19
RNA polymerase 19
tryptophan hydroxylase 19
lysozyme 16
urease 15
urease 15
phosphatidylinositol 3-kinase 15
prostate-specific membrane antigen 15
phosphorylase 15
alpha-glucosidase 14
ribonuclease 14
thymidine kinase 14
ribonuclease 14
alanine aminotransferase 13
carbonic anhydrase 13
kallikrein 13
ACS 13
CaMKII 12
phosphoenolpyruvate carboxykinase 12
phenylethanolamine N-methyltransferase 12
Lys4 12
thrombin 12
beta-galactosidase 11
furin 11
phosphoinositide 3-kinase 11
sucrase 11
CPT 10
glyceraldehyde-3-phosphate dehydrogenase 10
glutathione peroxidase 10
monoamine oxidase 10
lipoprotein lipase 10
GRK5 10
phosphoenolpyruvate carboxykinase 10
glyceraldehyde-3-phosphate dehydrogenase 10
phosphoenolpyruvate carboxykinase 10
invertase 9
prostate-specific antigen 9
glucose-6-phosphate dehydrogenase 9
glyceraldehyde-3-phosphate dehydrogenase 9
cytochrome oxidase 9
ornithine decarboxylase 9
aspartate aminotransferase 9
proprotein convertase 9
CD13 8
glucose-6-phosphatase 8
MAP 8
glyceraldehyde-3-phosphate dehydrogenase 8
glyceraldehyde-3-phosphate dehydrogenase 8
elastase 8
alpha-amylase 8
urokinase-type plasminogen activator 7
CPT 7
CPT 7
GRK2 7
proteasome 7
hyaluronidase 7
MDP 7
N-acetyltransferase 6
S1 nuclease 6
caspase-8 6
succinate dehydrogenase 6
aromatic L-amino acid decarboxylase 6
aldose reductase 6
hyaluronidase 6
GABA transaminase 6
glutaminase 5
ADH 5
PTR 5
alcohol dehydrogenase 5
cathepsin B 5
asparaginase 5
cdc2 5
PARP 5
GAS 5
carboxypeptidase A 5
P-glycoprotein 5
lactase 5
AMP-activated protein kinase 5
lysin 5
thimet oligopeptidase 4
dipeptidyl peptidase IV 4
MIP 4
PAL 4
hexokinase 4
endothelin-converting enzyme 4
carboxypeptidase B 4
gamma-glutamyl transpeptidase 4
dihydrofolate reductase 4
prolyl endopeptidase 4
malate dehydrogenase 4
glutathione S-transferase 4
PKG 4
beta-glucuronidase 4
UDP-glucuronosyltransferase 4
PCP 4
adenosine deaminase 4
5'-nucleotidase 4
carboxypeptidase E 4
DOPA decarboxylase 4
adenosine deaminase 4
neurolysin 4
pyruvate dehydrogenase 4
subtilisin 4
DNase 4
CPR 4
tissue plasminogen activator 4
plasmin 3
neuraminidase 3
more...
Compound
glucose 2661
Clin 1572
Dec 1538
calcium 1059
cAMP 694
arginine 571
Octreotide 560
Insulin 545
tyrosine 530
GABA 487
GABA 481
DNA 445
Phe 432
lysine 425
ACTH 422
sodium 413
TSH 381
TRH 355
AMP 334
water 326
glutamate 319
threonine 300
Glucagon 297
NH2 273
leucine 264
acetate 259
potassium 258
5-HT 254
noradrenaline 245
methionine 242
alanine 235
gamma-aminobutyric acid 220
Substance P 213
DTPA 187
GTP 164
His 163
nitric oxide 162
silver 150
phosphate 149
ATP 147
ethanol 142
Diabetol 116
galactose 109
Dopamine 104
acetic acid 102
iodine 101
glycerol 100
oxygen 98
Gly 97
Ile 92
Calcitonin 81
HCl 80
isoleucine 77
isoleucine 76
Secretin 75
Cysteamine 75
Thyroid 74
ACh 73
Adrenal 73
Neurotensin 73
sulfate 71
cGMP 70
salt 69
Atropine 69
NMDA 69
tryptophan 66
L-DOPA 65
Cereb 64
ADP 63
Forskolin 63
hydroxyindoleacetic acid 62
ADP 62
Neuronal 61
cysteine 61
ADP 61
alloxan 61
nitrogen 61
serine 61
urea 59
tryptophan 59
PAP 58
PAP 58
PAP 58
PAP 58
tryptophan 57
PGE2 57
tryptophan 57
nicotinamide 57
fluorine 55
PEG 55
Norepinephrine 53
prostaglandin E1 50
FFA 49
Asp 48
aldosterone 48
zinc 48
COS 47
Capsaicin 46
STZ 45
EDTA 43
Vasopressin 43
EDTA 43
Histamine 42
hydrogen 42
PEG 39
CO2 39
SDS 38
creatinine 37
Diabetol 36
1,4,7,10-tetraazacyclododecane 36
5-hydroxytryptophan 36
Mg2+ 36
Cortisol 36
glutamine 35
retinoic acid 35
AMPA 34
MDA 33
proline 32
alpha-MSH 32
NADPH 32
bromide 31
glutamic acid 31
NADPH 31
Propranolol 30
Carbachol 30
Propranolol 30
TNF 30
GDP 29
Pentagastrin 29
Naloxone 29
carbonate 29
BON 28
copper 27
5-HIAA 27
Optimal 26
formaldehyde 26
GSH 25
ammonia 25
Omeprazole 25
GSH 25
cobalt 24
iron 23
Oxytocin 23
Salt 22
Bromocriptine 22
valine 22
Pyridostigmine 22
formaldehyde 22
ammonium 21
DMSO 21
Cardiol 21
Dexamethasone 21
acetone 21
aspartic acid 20
CAT 20
CAT 20
Glutamate 20
Diazoxide 20
CAT 20
CYN 19
more...