Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P61278 (somatostatin)
 22,083 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pancreatic fistulas (PF) develop in about 20% of cases operated for pancreatic pseudocysts. The authors analyse 81 cases of postoperative PF. These were formed following 991 operations performed for pancreatic pseudocysts (PPCs) in 850 patients from 1987 to 1992. It is concluded that the incidence of PF formation is significantly (P < 0.01) increased following interventions for acute-type pseudocysts and after external drainage. One-third of the fistulas closed spontaneously within 1-4 weeks, while another 1/3 persisted for 1-6 months before gradual closure. Closure of fistulas was facilitated by inhibition of pancreatic secretion with Somatostatin or endoscopic intervention (EST, endoprosthesis) in 24% of all cases. Only 15% (14 cases), of the fistulas, i.e. 1% of total patients, required surgery. The procedure of choice in the 14 cases was exstirpation of fistulas alone (2 cases) or combined with necrectomy (10 cases), or with distal pancreatic resection (2 cases). In cases of drained pancreatic fistulas observation can be an appropriate treatment option, while long-standing fistulas producing large amounts require intervention.
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PMID:The outcome of pancreatic fistulas developed after surgery for pancreatic pseudocysts. 865 35

Somatostatin and the long acting analogue octreotide have been proposed as a therapeutic agent in acute pancreatitis and for the prophylaxis of pancreatic damage by ERCP and EST for their ability to reduce exocrine pancreatic secretion. However, clinical trials could not show significant beneficial effects in acute pancreatitis and ERCP. In patients undergoing EST, data remained controversial, most authors describing positive effects of prophylaxis. In this study we investigated the use of octreotide prophylaxis to reduce EST-induced pancreatic damage in a randomised, double blind trial. 94 consecutive ERCP/EST-patients were randomised to receive either octreotide 200 microgram s.c. or placebo 3 times daily, starting the night before endoscopic procedures. In 59 patients EST was performed. Blood samples were collected before and 40 min, 2 hrs, 6 hrs, 24 hrs, 48 hrs and 72 hrs after the endoscopic procedures. Samples were analysed for pancreatic serum enzymes, acute phase proteins and blood counts. A clinical pain score was investigated. Post-EST-pancreatitis (amylase > 3x upper limit and persistent abdominal pain) was diagnosed in 3 patients in the treatment group, in 4 patients in the placebo group. There were no significant differences in the time-courses of serum enzymes or acute phase proteins in-between the groups, nor in the pain-score. According to these data, prophylactic octreotide application does not prevent acute pancreatic damage induced by endoscopic sphincterotomy.
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PMID:Octreotide in the prevention of pancreatic damage induced by endoscopic sphincterotomy. 1079 51

The ingestion of a valine (Val)-deficient diet results in a significant reduction of food intake and body weight within 24 h, and this phenomenon continues throughout the period over which such a diet is supplied. Both microarray and real-time PCR analyses revealed that the expression of somatostatin mRNA was increased in the hypothalamus in anorectic mice that received a Val-deficient diet. On the other hand, when somatostatin was administered intracerebroventricularly to intact animals that were fed a control diet, their 24-h food intake decreased significantly. In addition, Val-deficient but not pair-fed mice or those fasted for 24 h showed a less than 0.5-fold decrease in the hypothalamic mRNA expression levels of Crym, Foxg1, Itpka and two unknown EST clone genes and a more than twofold increase in those of Slc6a3, Bdh1, Ptgr2 and one unknown EST clone gene. These results suggest that hypothalamic somatostatin and genes responsive to Val deficiency may be involved in the central mechanism of anorexia induced by a Val-deficient diet.
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PMID:Somatostatin is involved in anorexia in mice fed a valine-deficient diet. 2129 91