Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P61278 (somatostatin)
 22,083 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Administered intrathecally (IT) to mice, the putative substance P antagonist [D-Pro2,D-Trp7,9-substance P (DPDT) blocked substance P- and serotonin-induced reciprocal hindlimb scratching with ID50 values of 4.6 (2.9-6.9) and 3.0 (1.9-4.8) micrograms, respectively. The duration of this antagonistic effect was 90-120 min. In contrast, DPDT did not block bombesin-, somatostatin-, glycine- or glutamate-induced scratching. These data indicate that DPDT is an effective antagonist of serotonin-induced behaviors in the mouse spinal cord. Phenoxybenzamine (IT) also blocked substance P- and serotonin-induced scratching. Its onset of action was more rapid for serotonin than for DPDT implying differences in agonist-induced receptor activation. Methysergide (IT) blocked serotonin-induced scratching [ID50 = 0.7 (0.3-1.5) micrograms], but not substance P-induced scratching. Similar to DPDT, [D-Arg1,D-Trp7,9,Leu11]-substance P, [des-Arg1,D-Pro2, D-Trp7,9]-substance P(2-11) and [D-Pro4,D-Trp7,9]-substance P(4-11) blocked substance P and serotonin-induced scratching. In contrast, [D-Pro2,D-Phe7,D-Trp9]-substance P and [D-Pro4,D-Trp7,9,10]-substance P(4-11) blocked only substance P-induced scratching. Thus, some, but not all putative substance P antagonists may also be behavioral antagonists of serotonin in the mouse spinal cord.
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PMID:Interactions of substance P antagonists with serotonin in the mouse spinal cord. 246 43

The effect of somatostatin on lateral hypothalamic self-stimulation was investigated in atropine- and methysergide-pretreated rats. Somatostatin markedly decreased the self-stimulation rate of the animals. Atropine in a dose which had no action on self-stimulation partly antagonized the effect of somatostatin. Methysergide potentiated the somatostatin-induced depression of self-stimulation behavior. These results suggest that the central cholinergic and serotoninergic systems may play a role in the somatostatin-induced inhibition of self-stimulation.
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PMID:The effect of somatostatin on self-stimulation behavior in atropine- and methysergide-pretreated rats. 613 93

The role of 5-hydroxytryptamine (5-HT) in the acute regulation of the rat brain somatostatin (SS) receptor-effector system and somatostatin-like immunoreactivity (SSLI) content was examined. 5-HT administered i.c.v. in a volume of 10 microliters at a dose of 0.5 microgram (pH 3.4) increased the SSLI concentration at 60 min in the Wistar rat frontoparietal cortex and hippocampus (60%, P < 0.05; 72%, P < 0.01; respectively). These changes were associated with a significant increase in the total number of specific SS receptors in the frontoparietal cortex (24%, P < 0.05) and hippocampus (20%, P < 0.05), without changes in the affinity constant as compared with the control group. No significant differences were seen in the basal and forskolin (FK)-stimulated adenylate cyclase (AC) activities in both brain areas of 5-HT-treated rats when compared to the control group. The capacity of SS to inhibit the FK-stimulated AC activity in the frontoparietal cortex and hippocampus of 5-HT-treated rats was lower than in the control groups. The ability of the stable GTP analogue 5'-guanylylimidodiphosphate (Gpp(NH)p) to inhibit FK-stimulated AC activity in frontoparietal cortical and hippocampal membranes was markedly decreased in 5-HT-treated rats. To determine if the above-mentioned changes were related to the 5-HT activation of central 5-HT1 and 5-HT2 receptors, a non-selective 5-HT1 and 5-HT2 receptor antagonist, methysergide, was administered 60 min before the 5-HT injection. Pretreatment with methysergide (5 mg/kg i.p. in a volume of 400 microliters) prevented the 5-HT-induced changes in the SS receptor-effector system and in SSLI levels in both brain areas. Methysergide alone had no observable effect on the somatostatinergic system. These results suggest that the frontoparietal cortical and hippocampal somatostatinergic system can be regulated by 5-HT receptors.
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PMID:Modulation by 5-hydroxytryptamine of the somatostatin receptor-effector system and somatostatin levels in rat brain. 873 59