Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P61278 (somatostatin)
 22,083 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The effects of somatostatin-14 and its biologically active analogs, RC-160 and SMS 201-995, on (Ca,Mg)ATPase activity in vitro were studied in homogenates of anterior pituitary cells. It was found that somatostatin inhibited the (Ca,Mg)ATPase activity in the anterior pituitary and somatostatin analogs exerted slight biphasic effects on the calcium pump activity. The effects of specific brain (Ca,Mg)ATPase inhibitors, VOSO4 and LaCl3, were also studied in vitro. Neither VOSO4 nor LaCl3 enhance the inhibition of calcium pump activity caused by somatostatin. It is suggested that somatostatin may mediate its action in pituitary cells, among others, by the regulation of (Ca,Mg)ATPase activity.
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PMID:Effects of somatostatin-14 and its analogs on the (Ca,Mg)ATPase in the rat anterior pituitary. 167 1

1. Influence of some neurotransmitters and neuromodulators on the PMA-stimulated phosphorylation in vitro of calcium pump-like protein from rat cerebellum synaptosomal membranes was examined. 2. The prolonged time (up to 6 min) of synaptosomal membranes preincubation with 1 and 10 microM serotonin results in the increase of phosphorylation. The decrease of phosphorylation up to 80% of control value was observed for 100 microM serotonin. 3. The most stimulating effect on 130 kDa protein phosphorylation was observed with 1 microM of histamine (160% of control value). 4. 1 and 0.1 microM somatostatin triggered a short-time transient increase of 130 kDa phosphorylation (up to 135% of control value).
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PMID:Serotonin, histamine and somatostatin modulation of PMA-stimulated phosphorylation of 130 kDa Ca2+ pump-like protein from rat cerebellum synaptosomal membranes. 809 24