Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P61278 (
somatostatin
)
22,083
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Glycoprotein hormone adenomas represent approximately 25% of all pituitary adenomas. Although surgery and radiation are the primary therapeutic modalities, there is an important need for the development of adjunctive medical therapy for these tumors. Investigations have focused on the suppression of
GPH
synthesis and secretion by hypothalamic regulatory factors in an attempt to decrease tumor mass. Although GnRH agonist analogues have not produced consistent
GPH
suppression, they may be valuable tools to investigate the regulation of intact
GPH
and subunit secretion in these tumors. Preliminary reports have shown that analogues of dopamine and
somatostatin
may be therapeutically useful. However, careful in vivo and in vitro characterization of tumors within this very heterogeneous group and correlation with their response to treatment are needed to establish guidelines for effective medical therapy.
...
PMID:Medical therapy of glycoprotein hormone-secreting pituitary tumors. 266 78
