Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P61278 (
somatostatin
)
22,083
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Octreotide is a
somatostatin
(
SST
) analogue currently used in the treatment of neuroendocrine tumors (NETs) with high binding affinity for the somatostatin receptor-2 (SSTR2) that is also overexpressed in non-small cell lung cancer cell (NSCLC). Alpha-particle-emitting astatine-211 (
211
At) is a promising radionuclide with appropriate physical and chemical properties for use in targeted anticancer therapies. To obtain an additional pharmacological agent for the treatment of NSCLC, we present the first investigation of the possible use of
211
At-labeled octreotide as a potential alpha-radionuclide therapeutic agent for NSCLC treatment.
211
At-
SPC
-octreotide exhibited observable higher uptake in lung, spleen, stomach and intestines than in other tissues. Through histological examination,
211
At-
SPC
-octreotide demonstrated much more lethal effect than control groups (PBS, octreotide and free
211
At). These promising preclinical results suggested that
211
At labeled octreotide deserved to be further developed as a new anticancer agent for NSCLC.
...
PMID:Evaluation of astatine-211-labeled octreotide as a potential radiotherapeutic agent for NSCLC treatment. 2942 31
