Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P61278 (
somatostatin
)
22,083
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The present experiments were designed to analyze the ability of
somatostatin
to modulate the proliferation of cultured rat mesangial cells. In the absence of fetal calf serum,
somatostatin
stimulated cell proliferation in a dose-dependent manner. In contrast, in proliferating cells,
somatostatin
inhibited cell proliferation, also in a dose-dependent fashion. Zaprinast, a rather specific
cyclic GMP phosphodiesterase
blocker, inhibited the
somatostatin
-dependent proliferation in the absence of growth factors. However, it potentiated the inhibitory effect on proliferating cells. These results support a dual role for
somatostatin
in the regulation of mesangial cell proliferation. The inhibitory effect of the peptide may be mediated by cyclic GMP.
...
PMID:A dual effect of somatostatin on the proliferation of cultured rat mesangial cells. 810 84
