Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P61278 (somatostatin)
 22,083 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The prophylactic effect of perioperative use of somatostatin on postoperative increase of pancreatic enzymes was investigated in this double blind, randomized study. Thirty tree patients undergoing pancreatic surgery because of chronic pancreatitis or its complications were divided randomly into two groups. Fifteen patients received somatostatin (dose 125 micrograms/hour), 18 placebo-infusion pre-, and postoperatively for a total time of 48 hours. The level of serum amylase, lipase, gammaGT, calcium, creatinine and blood glucose was determined every 12 hours. In the placebo treated group the serum lipase and amylase increased significantly (p < 0.001), while the calcium decreased. In the somatostatin treated patients only the lipase level increased significantly (p < 0.01), while the amylase and calcium showed no significant changes compared to their initial values. The postoperative increase in serum enzyme levels is interpreted as being an indicator of pancreatic injury. These results suggest that the perioperative use of somatostatin has beneficial effect for the prevention of pancreatic enzymes increases and of pancreatic injuries, associated with pancreatic surgery in patients with chronic pancreatitis. The clinical experiences suggest that the asymptomatic increase in pancreatic amylase following abdominal surgery is the result of various types of injuries of the pancreas (1-3). Included in these injuries is the direct mechanical damage of the parenchyma and ducts but it can develop secondary, as a result of vascular lesion, ischaemia, oedema as well as mechanical injury to the Oddi sphincter of the sphincter's drug induced spasm (1, 2). The asymptomatic increase in serum amylase and lipase can thus be interpreted as being an indicator of surgical pancreatic injury (3).(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Perioperative use of somatostatin in pancreatic surgery. 752 8

Somatostatin and somatostatin analogues are considered very useful for the treatment of hormone producing tumors and acute variceal bleeding. They have also been proposed for the treatment of acute pancreatitis and for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis although clinical trials have failed to show any efficacy. The authors report the case of a 45-year-old man, recently diagnosed of acromegaly, which developed an acute pancreatitis shortly after his first injection of lanreotide autogel. The patient developed a severe dilatation of his hypocontractile gallbladder with distension of the intra and extrahepatic biliary ducts, the choledochus and the main pancreatic duct, without lithiasis or other abnormalities at the papilla, which resolved spontaneously in a month. We consider that lanreotide most likely induced a functional spasm of the Sphincter of Oddi, with impairment of the biliary-pancreatic outflow, leading to an acute pancreatitis, and review the literature concerning this drug related pancreatitis.
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PMID:Lanreotide autogel-induced acute pancreatitis in a patient with acromegaly. 2274 14