Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UNIPROT:P61278 (
somatostatin
)
22,083
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In order to understand the role of
somatostatin
in tumor cell growth, the expression of
somatostatin
in 7 cultured brain tumor cells was investigated. Radioimmunoassay demonstrated the production of
somatostatin
into the culture supernatant of 6 tumor cells. The expression of
somatostatin
mRNA and receptor was investigated by reverse transcription polymerase chain reaction (RT-PCR) and a binding assay with 125I-somatostatin-14, respectively. Only two cell lines,
GBS
-1 and U87MG, expressed
somatostatin
mRNA, whereas somatostatin receptor was expressed in all cultured cells. These results suggest that
somatostatin
is an important factor for regulating cell growth.
...
PMID:Expression of somatostatin messenger RNA and receptor in cultured brain tumor cells. 985 98
