Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UNIPROT:P61278 (somatostatin)
 22,083 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Many clinical approaches for the treatment of hormone-sensitive tumors are being developed based on analogs of LH-RH and somatostatin. Inhibition of the pituitary-gonadal axis forms the basis for oncological applications of LH-RH agonists like [D-Trp6]-LH-RH and new LH-RH antagonists free of edematogenic effects such as [Ac-D-Nal(2)1-D-Phe(4Cl)2-D-Pal(3)3,D-Cit6,D-Ala10]-LH -RH (SB-75). Agonists and antagonists of LH-RH have been used in patients with prostate cancer and might be also beneficial for the treatment of breast cancer and ovarian, endometrial and pancreatic carcinomas. Some of the effects of LH-RH analogs can be due to direct action since LH-RH receptors have been found in these cancers. The use of sustained delivery systems based on microcapsules of PLG, makes the treatment more efficacious. Octapeptide analogs of somatostatin such as D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Trp-NH2 (RC-160) and related analogs were designed specifically for antitumor activity. These somatostatin analogs, by virtue of having a wide spectrum of activities appear to inhibit various tumors through multiple mechanisms. Direct antiproliferative actions of somatostatin analogs appear to be mediated by specific receptors located on tumor cells. High affinity binding sites for RC-160 and related analogs have been found in human pancreatic, prostate, breast and ovarian cancers and brain tumors such as meningiomas. In vivo administration of analog RC-160 inhibits the growth of Dunning R-3327 prostate cancers in rats, MXT mammary tumors in mice and BOP-induced ductal pancreatic cancers in hamsters. Combination of microcapsules of RC-160 with [D-Trp6]-LH-RH results in synergistic potentiation of the inhibition of these cancers. Somatostatin analog RC-160 and LH-RH antagonist SB-75 are the object of further experimental studies and clinical trials aimed at the exploration of their inhibitory effects on the processes of malignant growth.
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PMID:Antitumor effects of analogs of LH-RH and somatostatin: experimental and clinical studies. 198 Oct 9

The comparative effects of thyroliberin (TRH), pentagastrin, C-terminal tripeptides of gastrin (MNF), luliberin (RPG) and its analog (RPF), oxytocin (PLG) and N-terminal tripeptide of angiotensin (NRV) on the glucose concentration in mouse blood, as well as the interrelationship between the peptides under study and insulin and somatostatin, were studied. It was found that all the peptides (except PLG) at doses 5, 50 and 100 mg/kg (intraperitoneally) exert a hypoglycemic effect comparable to that of insulin at the dose of 0,15 MU/kg (subcutaneously). The dose-dependent effect is observed only in the case of TRH. Somatostatin reverses the hypoglycemic action of TRH, MNF and NRV. TRH and RPF decrease the glucose-induced rise in insulin concentration measured by RIA. The structure-activity relationship and possibility of the formation of endogenous peptide hormone fragments as products of hormone molecules enzymatic cleavage and their glucoregulatory role are discussed.
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PMID:[Effect of peptide hormone fragments and thyroliberin on mouse blood glucose homeostasis]. 678 67