Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UNIPROT:P61278 (somatostatin)
 22,083 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a prospective clinical-experimental study, 15 patients with chronic pancreatitis operated consecutively due to severe pain were examined for the effects of a duodenum-preserving resection of the pancreas head on endocrine pancreas function. This was done by means of oral and intravenous glucose tolerance testing before the operation, on the 10th or 11th postoperative day, and three months after the operation. In addition to glucose levels in the peripheral venous blood, levels of insulin, C-peptide, glucagon, somatostatin, and pancreatic polypeptide were determined. As indicated by the k-value, glucose tolerance improved postoperatively in 11 patients; two patients showed no change, and one patient was worse. Only one patient developed evident diabetes mellitus immediately postoperatively. The pre- and postoperative levels of insulin and C-peptide showed no significant differences. The fasting levels of glucagon were significantly lower postoperatively than before the operation (2p less than 0.01). Duodenum-preserving pancreas head resection led to improvement of the glucose tolerance in the majority of patients; a deterioration was observed only in two cases.
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PMID:[The effect of duodenum-preserving pancreatic head resection on the endocrine pancreas function in patients with chronic head pancreatitis]. 134 82

We studied the early time-course of gastrin, somatostatin, and gut growth responses to 70% resection of mid-small intestine. Serum and antral gastrin increased by the 2nd day following resection and remained elevated for the 10-day period of study. Antral somatostatin remained unchanged, suggesting that the increase in gastrin was a selective antral response. Duodenum and ileum showed marked growth stimulation, which was progressive with time, and earlier and greater in duodenum. In contrast, gastric growth was unaffected. Thus, early responses to resection are characterized by specificity of gastrin, somatostatin, and growth effects.
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PMID:Gastrin, somatostatin, and alimentary tract growth responses to small intestinal resection in the rat. 290 94